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7BY6

Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389

Summary for 7BY6
Entry DOI10.2210/pdb7by6/pdb
DescriptorPhenylalanyl-tRNA synthetase beta chain, putative, (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsaminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, auxiliary pocket, heterotetrameric, ligase
Biological sourcePlasmodium vivax
More
Total number of polymer chains2
Total formula weight107447.67
Authors
Malhotra, N.,Manmohan, S.,Harlos, K.,Melillo, B.,Schreiber, S.L.,Manickam, Y.,Sharma, S. (deposition date: 2020-04-21, release date: 2020-11-04, Last modification date: 2023-11-29)
Primary citationSharma, M.,Malhotra, N.,Yogavel, M.,Harlos, K.,Melillo, B.,Comer, E.,Gonse, A.,Parvez, S.,Mitasev, B.,Fang, F.G.,Schreiber, S.L.,Sharma, A.
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
Nat Commun, 12:343-343, 2021
Cited by
PubMed: 33436639
DOI: 10.1038/s41467-020-20478-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.997 Å)
Structure validation

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