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8C0E
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BU of 8c0e by Molmil
The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase Wzz form a complex in vivo and in vitro
Descriptor: ECA polysaccharide chain length modulation protein
Authors:Weckener, M, Woodward, L.S, Clarke, B.R, Liu, H, Ward, P.N, Le Bas, A, Bhella, D, Whitfield, C, Naismith, J.H.
Deposit date:2022-12-16
Release date:2023-04-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex.
Open Biology, 13, 2023
8D3F
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BU of 8d3f by Molmil
Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST
Descriptor: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST
Authors:Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D.
Deposit date:2022-06-01
Release date:2022-07-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.
Nat Commun, 13, 2022
3J17
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BU of 3j17 by Molmil
Structure of a transcribing cypovirus by cryo-electron microscopy
Descriptor: Structural protein VP3, Structural protein VP5, VP1
Authors:Yang, C, Ji, G, Liu, H, Zhang, K, Liu, G, Sun, F, Zhu, P, Cheng, L.
Deposit date:2011-12-25
Release date:2012-04-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of a transcribing cypovirus.
Proc.Natl.Acad.Sci.USA, 109, 2012
5GWZ
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BU of 5gwz by Molmil
The structure of Porcine epidemic diarrhea virus main protease in complex with an inhibitor
Descriptor: N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, PEDV main protease
Authors:Wang, F, Chen, C, Yang, K, Liu, X, Liu, H, Xu, Y, Chen, X, Liu, X, Cai, Y, Yang, H.
Deposit date:2016-09-14
Release date:2017-03-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60, 2017
6E67
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BU of 6e67 by Molmil
Structure of beta2 adrenergic receptor fused to a Gs peptide
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera
Authors:Liu, X, Xu, X, Hilger, D, Tiemann, J, Liu, H, Du, Y, Hirata, K, Sun, X, Guixa-Gonzalez, R, Mathiesen, J, Hildebrand, P, Kobilka, B.
Deposit date:2018-07-24
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell, 177, 2019
6XKQ
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BU of 6xkq by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-250
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CV07-250 Heavy Chain, CV07-250 Light Chain, ...
Authors:Yuan, M, Liu, H, Zhu, X, Wu, N.C, Wilson, I.A.
Deposit date:2020-06-26
Release date:2020-10-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Cell, 183, 2020
5U6I
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BU of 5u6i by Molmil
Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity
Descriptor: 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W.
Deposit date:2016-12-08
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J. Med. Chem., 60, 2017
8JPC
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BU of 8jpc by Molmil
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
8JPF
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BU of 8jpf by Molmil
Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
8JPE
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BU of 8jpe by Molmil
Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ...
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
8JPB
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BU of 8jpb by Molmil
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
Descriptor: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
8JPD
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BU of 8jpd by Molmil
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Descriptor: Beta-adrenergic receptor kinase 1, STAUROSPORINE
Authors:Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E.
Deposit date:2023-06-11
Release date:2023-08-09
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
2X5F
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BU of 2x5f by Molmil
Crystal structure of the methicillin-resistant Staphylococcus aureus Sar2028, an aspartate_tyrosine_phenylalanine pyridoxal-5'-phosphate dependent aminotransferase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ASPARTATE_TYROSINE_PHENYLALANINE PYRIDOXAL-5' PHOSPHATE-DEPENDENT AMINOTRANSFERASE, MAGNESIUM ION, ...
Authors:Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
Deposit date:2010-02-08
Release date:2010-07-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genom., 11, 2010
6PT0
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BU of 6pt0 by Molmil
Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2
Descriptor: CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q.
Deposit date:2019-07-14
Release date:2020-02-12
Last modified:2020-03-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
2X3F
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BU of 2x3f by Molmil
Crystal Structure of the Methicillin-Resistant Staphylococcus aureus Sar2676, a Pantothenate Synthetase.
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, PANTHOTHENATE SYNTHETASE, SULFATE ION
Authors:Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H.
Deposit date:2010-01-24
Release date:2010-07-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genom., 11, 2010
1ST0
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BU of 1st0 by Molmil
Structure of DcpS bound to m7GpppG
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
1ST4
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BU of 1st4 by Molmil
Structure of DcpS bound to m7GpppA
Descriptor: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, YTTRIUM (III) ION, mRNA decapping enzyme
Authors:Gu, M, Fabrega, C, Liu, S.W, Liu, H, Kiledjian, M, Lima, C.D.
Deposit date:2004-03-24
Release date:2004-04-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
Mol.Cell, 14, 2004
7KZ7
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BU of 7kz7 by Molmil
Crystals Structure of the Mutated Protease Domain of Botulinum Neurotoxin X (X4130B1).
Descriptor: 1,2-ETHANEDIOL, Botulinum neurotoxin type X, GLYCEROL, ...
Authors:Blum, T.R, Liu, H, Packer, M.S, Xiong, X, Lee, P.G, Zhang, S, Richter, M, Minasov, G, Satchell, K.J.F, Dong, M, Liu, D.R, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-12-10
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.
Science, 371, 2021
1AZV
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BU of 1azv by Molmil
FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN)
Descriptor: COPPER (II) ION, COPPER/ZINC SUPEROXIDE DISMUTASE, ZINC ION
Authors:Hart, P.J, Liu, H, Pellegrini, M, Nersissian, A.M, Gralla, E.B, Valentine, J.S, Eisenberg, D.
Deposit date:1997-11-21
Release date:1998-02-25
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.
Protein Sci., 7, 1998
5C90
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BU of 5c90 by Molmil
Staphylococcus aureus ClpP mutant - Y63A
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit
Authors:Ye, F, Liu, H, Zhang, J, Gan, J, Yang, C.-G.
Deposit date:2015-06-26
Release date:2016-05-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure
Acs Chem.Biol., 11, 2016
7KH0
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BU of 7kh0 by Molmil
Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex
Descriptor: Arg-vasopressin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, L, Xu, J, Gao, S, Sun, D, Liu, H, Liu, Z, Du, Y, Zhang, C.
Deposit date:2020-10-19
Release date:2021-05-26
Last modified:2023-03-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structure of the AVP-vasopressin receptor 2-G s signaling complex.
Cell Res., 31, 2021
4FZ3
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BU of 4fz3 by Molmil
Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin
Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ...
Authors:Liu, D, Wu, J, Zhang, D, Chen, K, Jiang, H, Liu, H.
Deposit date:2012-07-06
Release date:2013-03-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate
J.Med.Chem., 56, 2013
3TI4
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BU of 3ti4 by Molmil
Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-9-O-octanoyl-D-glycero-D-galacto-non-2-enonic acid, ACETATE ION, ...
Authors:Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIC
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BU of 3tic by Molmil
Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIA
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BU of 3tia by Molmil
Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ...
Authors:Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011

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