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3TIB

Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir octanoate

Summary for 3TIB
Entry DOI10.2210/pdb3tib/pdb
Related3TI3 3TI4 3TI5 3TI6 3TI8 3TIA 3TIC
DescriptorNeuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords6-bladed beta-propeller, calcium binding, glycosylation, antiviral, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceInfluenza A virus
Total number of polymer chains4
Total formula weight215032.09
Authors
Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. (deposition date: 2011-08-20, release date: 2011-11-16, Last modification date: 2023-11-01)
Primary citationVavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F.
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7:e1002249-e1002249, 2011
Cited by
PubMed: 22028647
DOI: 10.1371/journal.ppat.1002249
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.201 Å)
Structure validation

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