3TI4
Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate
Summary for 3TI4
Entry DOI | 10.2210/pdb3ti4/pdb |
Related | 3NSS 3TI3 3TI5 3TI6 3TI8 3TIA 3TIB 3TIC |
Descriptor | Neuraminidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | 6-bladed beta-propeller, calcium binding, glycosylation, antiviral, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus |
Total number of polymer chains | 2 |
Total formula weight | 88492.43 |
Authors | |
Primary citation | Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7:e1002249-e1002249, 2011 Cited by PubMed: 22028647DOI: 10.1371/journal.ppat.1002249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.602 Å) |
Structure validation
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