8VBT
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4PKX
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![BU of 4pkx by Molmil](/molmil-images/mine/4pkx) | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | Descriptor: | Protein C10C5.1, isoform i | Authors: | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | Deposit date: | 2014-05-15 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold. Structure, 22, 2014
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1LX8
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![BU of 1lx8 by Molmil](/molmil-images/mine/1lx8) | Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein | Descriptor: | Excisionase | Authors: | Sam, M.D, Papagiannis, C, Connolly, K.M, Corselli, L, Iwahara, J, Lee, J, Phillips, M, Wojciak, J.M, Johnson, R.C, Clubb, R.T. | Deposit date: | 2002-06-04 | Release date: | 2003-06-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Regulation of directionality in bacteriophage lambda site-specific recombination: structure of the Xis protein J.Mol.Biol., 324, 2002
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5F5R
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![BU of 5f5r by Molmil](/molmil-images/mine/5f5r) | TRAP1N-ADPNP | Descriptor: | Heat shock protein 75 kDa, mitochondrial, MAGNESIUM ION, ... | Authors: | Tsai, F.T.F, Lee, S, Sung, N, Lee, J, Chang, C, Joachimiak, A. | Deposit date: | 2015-12-04 | Release date: | 2016-03-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate. Proc.Natl.Acad.Sci.USA, 113, 2016
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4MN0
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![BU of 4mn0 by Molmil](/molmil-images/mine/4mn0) | Spatial structure of the novel light-sensitive photoprotein berovin from the ctenophore Beroe abyssicola in the Ca2+-loaded apoprotein conformation state | Descriptor: | Berovin, CALCIUM ION, MAGNESIUM ION | Authors: | Liu, Z.J, Stepanyuk, G.A, Vysotski, E.S, Lee, J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2013-09-09 | Release date: | 2013-10-16 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Spatial structure of the novel light-sensitive photoprotein berovin from the ctenophore Beroe abyssicola in the Ca(2+)-loaded apoprotein conformation state. Biochim.Biophys.Acta, 1834, 2013
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4N1G
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![BU of 4n1g by Molmil](/molmil-images/mine/4n1g) | Crystal Structure of Ca(2+)- discharged F88Y obelin mutant from Obelia longissima at 1.50 Angstrom resolution | Descriptor: | CALCIUM ION, N-[3-BENZYL-5-(4-HYDROXYPHENYL)PYRAZIN-2-YL]-2-(4-HYDROXYPHENYL)ACETAMIDE, Obelin | Authors: | Natashin, P.V, Markova, S.V, Lee, J, Vysotski, E.S, Liu, Z.J. | Deposit date: | 2013-10-04 | Release date: | 2014-02-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J., 281, 2014
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4N1F
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![BU of 4n1f by Molmil](/molmil-images/mine/4n1f) | Crystal Structure of F88Y obelin mutant from Obelia longissima at 2.09 Angstrom resolution | Descriptor: | C2-HYDROPEROXY-COELENTERAZINE, Obelin | Authors: | Natashin, P.V, Markova, S.V, Lee, J, Vysotski, E.S, Liu, Z.J. | Deposit date: | 2013-10-04 | Release date: | 2014-02-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Crystal structures of the F88Y obelin mutant before and after bioluminescence provide molecular insight into spectral tuning among hydromedusan photoproteins Febs J., 281, 2014
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2AZR
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![BU of 2azr by Molmil](/molmil-images/mine/2azr) | Crystal structure of PTP1B with Bicyclic Thiophene inhibitor | Descriptor: | 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase, non-receptor type 1 | Authors: | Moretto, A.F, Kirincich, S.J, Xu, W.X, Smith, M.J, Wan, Z.K, Wilson, D.P, Follows, B.C, Binnun, E, Joseph-McCarthy, D, Foreman, K, Erbe, D.V, Zhang, Y.L, Tam, S.K, Tam, S.Y, Lee, J. | Deposit date: | 2005-09-12 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem., 14, 2006
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2B07
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![BU of 2b07 by Molmil](/molmil-images/mine/2b07) | Crystal structure of PTP1B with Tricyclic Thiophene inhibitor. | Descriptor: | 6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase, non-receptor type 1 | Authors: | Moretto, A.F, Kirincich, S.J, Xu, W.X, Smith, M.J, Wan, Z.K, Wilson, D.P, Follows, B.C, Binnun, E, Joseph-McCarthy, D, Foreman, K, Erbe, D.V, Zhang, Y.L, Tam, S.K, Tam, S.Y, Lee, J. | Deposit date: | 2005-09-13 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem., 14, 2006
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3TUD
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![BU of 3tud by Molmil](/molmil-images/mine/3tud) | Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide | Descriptor: | N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide, Tyrosine-protein kinase SYK | Authors: | Lovering, F, McDonald, J, Whitlock, G, Glossop, P, Phillips, C, Sabnis, Y, Ryan, M, Fitz, L, Lee, J, Chang, J.S, Han, S, Kurumbail, R, Thorarenson, A. | Deposit date: | 2011-09-16 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80, 2012
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3TUC
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![BU of 3tuc by Molmil](/molmil-images/mine/3tuc) | Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Descriptor: | 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide, Tyrosine-protein kinase SYK | Authors: | Lovering, F, McDonald, J, Whitlock, G, Glossop, P, Phillips, C, Sabnis, Y, Ryan, M, Fitz, L, Lee, J, Chang, J.S, Han, S, Kurumbail, R, Thorarenson, A. | Deposit date: | 2011-09-16 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80, 2012
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2FB8
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![BU of 2fb8 by Molmil](/molmil-images/mine/2fb8) | Structure of the B-Raf kinase domain bound to SB-590885 | Descriptor: | (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, B-Raf proto-oncogene serine/threonine-protein kinase | Authors: | Lougheed, J.C, Lee, J, Chau, D.C, Stout, T.J. | Deposit date: | 2005-12-08 | Release date: | 2006-12-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res., 66, 2006
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5YO9
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5YOA
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5YZU
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4RS7
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2A8C
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![BU of 2a8c by Molmil](/molmil-images/mine/2a8c) | Haemophilus influenzae beta-carbonic anhydrase | Descriptor: | Carbonic anhydrase 2, SULFATE ION, ZINC ION | Authors: | Cronk, J.D, Rowlett, R.S, Zhang, K.Y.J, Tu, C, Endrizzi, J.A, Lee, J, Gareiss, P.C, Preiss, J.R. | Deposit date: | 2005-07-07 | Release date: | 2006-04-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase Biochemistry, 45, 2006
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2A8D
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![BU of 2a8d by Molmil](/molmil-images/mine/2a8d) | Haemophilus influenzae beta-carbonic anhydrase complexed with bicarbonate | Descriptor: | BICARBONATE ION, Carbonic anhydrase 2, SULFATE ION, ... | Authors: | Cronk, J.D, Rowlett, R.S, Zhang, K.Y.J, Tu, C, Endrizzi, J.A, Lee, J, Gareiss, P.C, Preiss, J.R. | Deposit date: | 2005-07-07 | Release date: | 2006-04-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase Biochemistry, 45, 2006
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4RS8
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3E2W
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3E24
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3CRG
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![BU of 3crg by Molmil](/molmil-images/mine/3crg) | Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala | Descriptor: | FORMIC ACID, GLYCEROL, Heparin-binding growth factor 1, ... | Authors: | Meher, A.K, Honjo, E, Kuroki, R, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2008-04-07 | Release date: | 2009-02-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1. Acta Crystallogr.,Sect.F, 65, 2009
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3CQA
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![BU of 3cqa by Molmil](/molmil-images/mine/3cqa) | Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala | Descriptor: | FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION | Authors: | Meher, A.K, Honjo, E, Kuroki, R, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2008-04-02 | Release date: | 2009-04-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1. Acta Crystallogr.,Sect.F, 65, 2009
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3CRI
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![BU of 3cri by Molmil](/molmil-images/mine/3cri) | Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala | Descriptor: | FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION | Authors: | Meher, A.K, Honjo, E, Kuroki, R, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2008-04-07 | Release date: | 2009-02-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1. Acta Crystallogr.,Sect.F, 65, 2009
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3CRH
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![BU of 3crh by Molmil](/molmil-images/mine/3crh) | Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala | Descriptor: | Heparin-binding growth factor 1, SULFATE ION | Authors: | Meher, A.K, Honjo, E, Kuroki, R, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2008-04-07 | Release date: | 2009-02-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1. Acta Crystallogr.,Sect.F, 65, 2009
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