2B07
Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.
Summary for 2B07
Entry DOI | 10.2210/pdb2b07/pdb |
Related | 2AZR |
Descriptor | Tyrosine-protein phosphatase, non-receptor type 1, 6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase, hydrolyase, tricyclic thiophenes, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35394.38 |
Authors | Moretto, A.F.,Kirincich, S.J.,Xu, W.X.,Smith, M.J.,Wan, Z.K.,Wilson, D.P.,Follows, B.C.,Binnun, E.,Joseph-McCarthy, D.,Foreman, K.,Erbe, D.V.,Zhang, Y.L.,Tam, S.K.,Tam, S.Y.,Lee, J. (deposition date: 2005-09-13, release date: 2005-12-06, Last modification date: 2024-02-14) |
Primary citation | Moretto, A.F.,Kirincich, S.J.,Xu, W.X.,Smith, M.J.,Wan, Z.K.,Wilson, D.P.,Follows, B.C.,Binnun, E.,Joseph-McCarthy, D.,Foreman, K.,Erbe, D.V.,Zhang, Y.L.,Tam, S.K.,Tam, S.Y.,Lee, J. Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem., 14:2162-2177, 2006 Cited by PubMed: 16303309DOI: 10.1016/j.bmc.2005.11.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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