1F1J
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4YDH
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![BU of 4ydh by Molmil](/molmil-images/mine/4ydh) | The structure of human FMNL1 N-terminal domains bound to Cdc42 | Descriptor: | Cell division control protein 42 homolog, Formin-like protein 1, MAGNESIUM ION, ... | Authors: | Kuhn, S, Anand, K, Geyer, M. | Deposit date: | 2015-02-22 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation. Nat Commun, 6, 2015
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4YC7
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2JRS
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![BU of 2jrs by Molmil](/molmil-images/mine/2jrs) | Solution NMR Structure of CAPER RRM2 Domain. Northeast Structural Genomics Target HR4730A | Descriptor: | RNA-binding protein 39 | Authors: | Rossi, P, Zhao, L, Nwosu, C, Cunningham, K, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-28 | Release date: | 2007-09-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of CAPER RRM2 Domain. To be Published
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1I09
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3IO7
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![BU of 3io7 by Molmil](/molmil-images/mine/3io7) | 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2 | Descriptor: | (3S)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-N,N-diethylpiperidine-3-carboxamide, Tyrosine-protein kinase JAK2 | Authors: | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | Deposit date: | 2009-08-13 | Release date: | 2009-11-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg.Med.Chem.Lett., 19, 2009
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3IOK
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![BU of 3iok by Molmil](/molmil-images/mine/3iok) | 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2 | Descriptor: | 3-(6-{[(1S)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine, Tyrosine-protein kinase JAK2 | Authors: | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | Deposit date: | 2009-08-14 | Release date: | 2009-11-10 | Last modified: | 2013-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg.Med.Chem.Lett., 19, 2009
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1JUO
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3N7P
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3N7S
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![BU of 3n7s by Molmil](/molmil-images/mine/3n7s) | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism | Descriptor: | Calcitonin gene-related peptide type 1 receptor, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)-N~2~-1H-indazol-5-yl-6-methylpyrimidine-2,4-diamine, ... | Authors: | Ter Haar, E. | Deposit date: | 2010-05-27 | Release date: | 2010-09-15 | Last modified: | 2022-10-26 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
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3N7R
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![BU of 3n7r by Molmil](/molmil-images/mine/3n7r) | Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism | Descriptor: | Calcitonin gene-related peptide type 1 receptor, N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ... | Authors: | Ter Haar, E. | Deposit date: | 2010-05-27 | Release date: | 2010-09-15 | Last modified: | 2022-10-26 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18, 2010
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2OIN
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![BU of 2oin by Molmil](/molmil-images/mine/2oin) | crystal structure of HCV NS3-4A R155K mutant | Descriptor: | NS4A peptide, Polyprotein, ZINC ION | Authors: | Wei, Y. | Deposit date: | 2007-01-11 | Release date: | 2007-06-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J.Biol.Chem., 282, 2007
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4YVC
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![BU of 4yvc by Molmil](/molmil-images/mine/4yvc) | ROCK 1 bound to thiazole inhibitor | Descriptor: | 2-fluoro-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide, Rho-associated protein kinase 1 | Authors: | Jacobs, M.D. | Deposit date: | 2015-03-19 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J.Med.Chem., 58, 2015
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4YVE
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![BU of 4yve by Molmil](/molmil-images/mine/4yve) | ROCK 1 bound to methoxyphenyl thiazole inhibitor | Descriptor: | 2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide, Rho-associated protein kinase 1 | Authors: | Jacobs, M.D. | Deposit date: | 2015-03-19 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J.Med.Chem., 58, 2015
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5BML
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![BU of 5bml by Molmil](/molmil-images/mine/5bml) | ROCK 1 bound to a pyridine thiazole inhibitor | Descriptor: | N-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide, Rho-associated protein kinase 1 | Authors: | Jacobs, M.D. | Deposit date: | 2015-05-22 | Release date: | 2015-06-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J.Med.Chem., 58, 2015
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2JXT
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![BU of 2jxt by Molmil](/molmil-images/mine/2jxt) | Solution structure of 50S ribosomal protein LX from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Consortium (NESG) target TR80 | Descriptor: | 50S ribosomal protein LX | Authors: | Liu, G, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-11-29 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution structure of 50S ribosomal protein LX from Methanobacterium thermoautotrophicum. To be Published
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2JXP
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![BU of 2jxp by Molmil](/molmil-images/mine/2jxp) | Solution NMR structure of uncharacterized lipoprotein B from Nitrosomonas europaea. Northeast Structural Genomics target NeR45A | Descriptor: | Putative lipoprotein B | Authors: | Rossi, P, Wang, D, Janjua, H, Owens, L, Xiao, R, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-11-27 | Release date: | 2007-12-11 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of uncharacterized lipoprotein B from Nitrosomonas europaea. To be Published
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2JUW
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![BU of 2juw by Molmil](/molmil-images/mine/2juw) | NMR solution structure of homodimer protein SO_2176 from Shewanella oneidensis. Northeast Structural Genomics Consortium target SoR77 | Descriptor: | UPF0352 protein SO_2176 | Authors: | Ramelot, T.A, Cort, J.R, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-09-03 | Release date: | 2007-09-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR solution structure of homodimer protein SO_2176 from Shewanella oneidensis. Northeast Structural Genomics Consortium target SoR77. To be Published
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2KCV
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![BU of 2kcv by Molmil](/molmil-images/mine/2kcv) | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c | Descriptor: | Tetratricopeptide repeat domain protein | Authors: | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-29 | Release date: | 2009-01-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c To be Published
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2JC2
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![BU of 2jc2 by Molmil](/molmil-images/mine/2jc2) | The crystal structure of the natural F112L human sorcin mutant | Descriptor: | SORCIN, SULFATE ION | Authors: | Franceschini, S, Ilari, A, Colotti, G, Chiancone, E. | Deposit date: | 2006-12-19 | Release date: | 2007-08-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular Basis for the Impaired Function of the Natural F112L Sorcin Mutant: X-Ray Crystal Structure, Calcium Affinity, and Interaction with Annexin Vii and the Ryanodine Receptor. Faseb J., 22, 2008
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2KK6
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![BU of 2kk6 by Molmil](/molmil-images/mine/2kk6) | Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d | Descriptor: | Proto-oncogene tyrosine-protein kinase FER | Authors: | Tang, Y, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-06-15 | Release date: | 2009-08-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d To be Published
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2KK0
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![BU of 2kk0 by Molmil](/molmil-images/mine/2kk0) | Solution structure of dead ringer-like protein 1 (at-rich interactive domain-containing protein 3a) from homo sapiens, northeast structural genomics consortium (NESG) target hr4394c | Descriptor: | AT-rich interactive domain-containing protein 3A | Authors: | Liu, G, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-06-14 | Release date: | 2009-07-14 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target. Proteins, 78, 2010
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2KCY
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![BU of 2kcy by Molmil](/molmil-images/mine/2kcy) | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D | Descriptor: | 30S ribosomal protein S8e | Authors: | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B.C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-30 | Release date: | 2009-01-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET TR71D To be Published
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2KK1
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![BU of 2kk1 by Molmil](/molmil-images/mine/2kk1) | Solution structure of C-terminal Domain of Tyrosine-protein kinase ABL2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) target HR5537A | Descriptor: | Tyrosine-protein kinase ABL2 | Authors: | Liu, G, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-06-14 | Release date: | 2009-08-11 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens. Proteins, 78, 2010
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2KCP
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![BU of 2kcp by Molmil](/molmil-images/mine/2kcp) | SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E; FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET Tr71d | Descriptor: | 30S ribosomal protein S8e | Authors: | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-24 | Release date: | 2009-07-14 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | SOLUTION STRUCTURE OF 30S RIBOSOMAL PROTEIN S8E FROM Methanothermobacter thermautotrophicus, NORTHEASTSTRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET To be Published
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