4YVE

ROCK 1 bound to methoxyphenyl thiazole inhibitor

Summary for 4YVE

• Entry DOI: 10.2210/pdb4yve/pdb
• Related: 4YVC
• Descriptor: Rho-associated protein kinase 1, 2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide (3 entities in total)
• Functional Keywords: kinase, dimer, dimerization, myosin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 96675.34

Authors

Jacobs, M.D. (deposition date: 2015-03-19, release date: 2015-06-10, Last modification date: 2023-09-27)

• Primary citation: Green, J.,Cao, J.,Bandarage, U.K.,Gao, H.,Court, J.,Marhefka, C.,Jacobs, M.,Taslimi, P.,Newsome, D.,Nakayama, T.,Shah, S.,Rodems, S.; Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.; J.Med.Chem., 58:5028-5037, 2015; PubMed: 26039570; DOI: 10.1021/acs.jmedchem.5b00424

Experimental method

X-RAY DIFFRACTION (3.4 Å)