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8GRN
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BU of 8grn by Molmil
AtOSCA1.1 extended state
Descriptor: Protein OSCA1, [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
Authors:Zhang, M.F.
Deposit date:2022-09-02
Release date:2023-06-14
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
8GSO
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BU of 8gso by Molmil
AtOSCA3.1 channel extended state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, M.F.
Deposit date:2022-09-06
Release date:2023-06-14
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
8GRO
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BU of 8gro by Molmil
AtOSCA3.1 contracted state
Descriptor: CSC1-like protein ERD4
Authors:Zhang, M.F.
Deposit date:2022-09-02
Release date:2023-06-14
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity.
Nat Commun, 14, 2023
5K55
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BU of 5k55 by Molmil
Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with fructose-6-phosphate
Descriptor: 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2016-05-23
Release date:2017-06-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.977 Å)
Cite:Structural studies of human muscle FBPase
To Be Published
5K56
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BU of 5k56 by Molmil
Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2016-05-23
Release date:2017-06-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structural studies of human muscle FBPase
To Be Published
6JXT
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BU of 6jxt by Molmil
Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization
Descriptor: CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Yun, C.H, Zhu, S.J, Yan, X.E.
Deposit date:2019-04-25
Release date:2020-04-29
Last modified:2020-11-04
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Structural Basis of AZD9291 Selectivity for EGFR T790M.
J.Med.Chem., 63, 2020
6JWL
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BU of 6jwl by Molmil
Crystal structure of EGFR 696-1022 L858R in complex with AZD9291
Descriptor: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Yun, C.H, Zhu, S.J, Yan, X.E.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2020-11-04
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Structural Basis of AZD9291 Selectivity for EGFR T790M.
J.Med.Chem., 63, 2020
6JX4
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BU of 6jx4 by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking
Descriptor: Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Zhu, S.J, Yan, X.E, Yun, C.H.
Deposit date:2019-04-22
Release date:2020-04-22
Last modified:2020-11-04
Method:X-RAY DIFFRACTION (2.531 Å)
Cite:Structural Basis of AZD9291 Selectivity for EGFR T790M.
J.Med.Chem., 63, 2020
6LTN
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BU of 6ltn by Molmil
cryo-EM structure of C-terminal truncated human Pannexin1
Descriptor: Pannexin-1
Authors:Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
Deposit date:2020-01-23
Release date:2020-05-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for gating mechanism of Pannexin 1 channel.
Cell Res., 30, 2020
6LTO
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BU of 6lto by Molmil
cryo-EM structure of full length human Pannexin1
Descriptor: Pannexin-1
Authors:Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
Deposit date:2020-01-23
Release date:2020-05-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for gating mechanism of Pannexin 1 channel.
Cell Res., 30, 2020
6JX0
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BU of 6jx0 by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization
Descriptor: CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Authors:Yun, C.H, Yan, X.E, Zhu, S.J.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2020-11-04
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural Basis of AZD9291 Selectivity for EGFR T790M.
J.Med.Chem., 63, 2020
5ET5
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BU of 5et5 by Molmil
Human muscle fructose-1,6-bisphosphatase in active R-state
Descriptor: Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
5ET8
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BU of 5et8 by Molmil
Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate
Descriptor: 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2015-11-17
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure
To Be Published
5ET6
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BU of 5et6 by Molmil
Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
5ET7
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BU of 5et7 by Molmil
Human muscle fructose-1,6-bisphosphatase in inactive T-state
Descriptor: Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
7YR5
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BU of 7yr5 by Molmil
Embigin facilitates monocarboxylate transporter 1 localization to plasma membrane and transition to a decoupling state
Descriptor: Embigin, Monocarboxylate transporter 1
Authors:Xu, B, Ye, S.
Deposit date:2022-08-08
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state.
Cell Rep, 40, 2022
7YIJ
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BU of 7yij by Molmil
Human KCNH5 pore dilation but the non-conducting state
Descriptor: POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5
Authors:Zhang, M.F.
Deposit date:2022-07-16
Release date:2023-04-05
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
6TWR
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BU of 6twr by Molmil
Structure of a constitutively active CAT-PRD1 mutant of the antiterminator LicT protein.
Descriptor: Beta-glucoside bgl operon antiterminator BglG family
Authors:Demene, H, Declerck, N, Yinshan, Y.
Deposit date:2020-01-13
Release date:2021-04-14
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Resolving the activation mechanism of the D99N antiterminator LicT protein.
J.Struct.Biol., 213, 2021
8T51
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BU of 8t51 by Molmil
Crystal structure of Fab 3.10C2 bound to TREM2
Descriptor: 3.10C2 Fab heavy chain, 3.10C2 Fab light chain, ACETATE ION, ...
Authors:Hsu, P.L, Wallweber, H.
Deposit date:2023-06-12
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
To Be Published
4LEX
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BU of 4lex by Molmil
Unliganded crystal structure of mAb7
Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN
Authors:Murray, J.M, Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
4LF3
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BU of 4lf3 by Molmil
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
Descriptor: Fab heavy chain, Fab light chain, Glucagon receptor
Authors:Murray, J.M, Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
5DLP
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BU of 5dlp by Molmil
Acetylcholinesterase Methylene Blue no PEG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ...
Authors:Dym, O.
Deposit date:2015-09-07
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016
5E2I
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BU of 5e2i by Molmil
Acetylcholinesterase Methylene Blue no PEG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, DECAMETHONIUM ION, ...
Authors:Dym, O.
Deposit date:2015-10-01
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016
5E4J
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BU of 5e4j by Molmil
Acetylcholinesterase Methylene Blue no PEG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, DECAMETHONIUM ION, ...
Authors:Dym, O.
Deposit date:2015-10-06
Release date:2016-03-30
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016
5E4T
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BU of 5e4t by Molmil
Acetylcholinesterase Methylene Blue with PEG
Descriptor: 1,2-ETHANEDIOL, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ...
Authors:Dym, O.
Deposit date:2015-10-07
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
Protein Sci., 25, 2016

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