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Crystal Structure of HIV-1 ConC_Base0 Prefusion Env Trimer in Complex with Human Antibody Fragment 3H109L and 35O22 variants at 3.5 Angstrom
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Lai, Y.-T, Kwong, P.D.
Deposit date:	2018-02-27
Release date:	2018-04-25
Last modified:	2022-03-23
Method:	X-RAY DIFFRACTION (2.714 Å)
Cite:	A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers. Cell Rep, 23, 2018

4ZPW

Structure of unbound MERS-CoV spike receptor-binding domain (England1 strain).
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, Spike glycoprotein
Authors:	Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D.
Deposit date:	2015-05-08
Release date:	2015-08-12
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.023 Å)
Cite:	Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun, 6, 2015

4ZMJ

Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:	Kwon, Y.D, Kwong, P.D.
Deposit date:	2015-05-04
Release date:	2015-06-24
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.31 Å)
Cite:	Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat.Struct.Mol.Biol., 22, 2015

6E5P

Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03
Descriptor:	2G12 Light chain, 2G12 heavy chain, Envelope glycoprotein gp120, ...
Authors:	Acharya, P, Kwong, P.D.
Deposit date:	2018-07-21
Release date:	2019-02-13
Last modified:	2024-03-13
Method:	ELECTRON MICROSCOPY (8.8 Å)
Cite:	Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition. Structure, 27, 2019

5C0S

Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261
Descriptor:	CR6261 antibody heavy chain, CR6261 antibody light chain, Hemagglutinin, ...
Authors:	Boyington, J.C, Kwong, P.D, Nabel, G.J, Mascola, J.R.
Deposit date:	2015-06-12
Release date:	2015-09-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (4.3 Å)
Cite:	Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat. Med., 21, 2015

5C0R

Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C179 Fab heavy chain, ...
Authors:	Boyington, J.C, kwong, P.D, Nabel, G.J, Mascola, J.R.
Deposit date:	2015-06-12
Release date:	2015-09-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.188 Å)
Cite:	Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat. Med., 21, 2015

6DE7

Crystal Structure at 4.3 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Interdomain Stabilization 113C-429GCG in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 heavy chain, ...
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2018-05-11
Release date:	2018-06-06
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (4.123 Å)
Cite:	Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer. Cell Host Microbe, 23, 2018

5DT1

Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody
Descriptor:	Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2015-09-17
Release date:	2015-10-21
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.954 Å)
Cite:	New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency. J.Virol., 90, 2015

5ESV

Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade C Superinfecting Strain of Donor CAP256.
Descriptor:	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Gorman, J, Yang, M, Kwong, P.D.
Deposit date:	2015-11-17
Release date:	2015-12-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.105 Å)
Cite:	Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nat.Struct.Mol.Biol., 23, 2016

5EWI

Crystal Structure of the Human Fab VRC38.01, an HIV-1 V1V2-Directed Neutralizing Antibody Isolated from Donor N90
Descriptor:	VRC38.01 Heavy Chain, VRC38.01 Light Chain
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2015-11-20
Release date:	2016-11-23
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.5996 Å)
Cite:	Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop. Immunity, 46, 2017

5ESZ

Crystal Structure of Broadly Neutralizing Antibody CH04, Isolated from Donor CH0219, in Complex with Scaffolded Trimeric HIV-1 Env V1V2 Domain from the Clade AE Strain A244
Descriptor:	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase,Envelope glycoprotein gp160, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH04 Heavy Chain, ...
Authors:	Gorman, J, Yang, M, Kwong, P.D.
Deposit date:	2015-11-17
Release date:	2015-12-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (4.191 Å)
Cite:	Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nat. Struct. Mol. Biol., 23, 2016

5FYJ

Crystal Structure at 3.4 A Resolution of Fully Glycosylated HIV-1 Clade G X1193.c1 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
Deposit date:	2016-03-08
Release date:	2016-04-27
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (3.11 Å)
Cite:	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016

5F9W

Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of CH235-lineage antibody CH235, Light chain of CH235-lineage antibody CH235, ...
Authors:	Chen, L, Zhou, T, Kwong, P.D.
Deposit date:	2015-12-10
Release date:	2016-03-09
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.8911 Å)
Cite:	Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165, 2016

5FYK

Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22, ...
Authors:	Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
Deposit date:	2016-03-08
Release date:	2016-04-27
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (3.107 Å)
Cite:	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016

5F96

Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.12 in complex with HIV-1 clade A/E 93TH057 gp120
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY CH235.12, ...
Authors:	Zhou, T, Kwong, P.D.
Deposit date:	2015-12-09
Release date:	2016-03-09
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.2407 Å)
Cite:	Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165, 2016

5FYL

Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 ANTIBODY FAB HEAVY CHAIN, ...
Authors:	Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
Deposit date:	2016-03-08
Release date:	2016-04-27
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016

5F89

Structure of the Unliganded Fab from HIV-1 Neutralising Antibody CAP248-2B that Binds to the gp120 C-terminus - gp41 Interface
Descriptor:	CAP248-2B Heavy Chain, CAP248-2B Light Chain
Authors:	Wibmer, C.K, Gorman, J, Kwong, P.D.
Deposit date:	2015-12-09
Release date:	2016-12-21
Last modified:	2017-03-29
Method:	X-RAY DIFFRACTION (2.7842 Å)
Cite:	Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape. PLoS Pathog., 13, 2017

5F9O

Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.09 in complex with HIV-1 clade A/E 93TH057 gp120
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CH235.09 Light chain, ...
Authors:	Joyce, M.G, Mascola, J.R, Kwong, P.D.
Deposit date:	2015-12-10
Release date:	2016-03-16
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (1.86 Å)
Cite:	Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165, 2016

7TCQ

Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide
Descriptor:	Anti-SARS-CoV-2 antibody WS6 Fab heavy chain, Anti-SARS-CoV-2 antibody WS6 Fab light chain, DI(HYDROXYETHYL)ETHER, ...
Authors:	Zhou, T, Kwong, P.D.
Deposit date:	2021-12-28
Release date:	2022-08-03
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability. Structure, 30, 2022

7U9O

SARS-CoV-2 spike trimer RBD in complex with Fab NE12
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, NE12 Fab heavy chain, NE12 Fab light chain, ...
Authors:	Tsybovsky, Y, Kwong, P.D, Farci, P.
Deposit date:	2022-03-11
Release date:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants. Cell Rep, 41, 2022

7U9P

SARS-CoV-2 spike trimer RBD in complex with Fab NA8
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, NA8 Fab heavy chain, NA8 Fab light chain, ...
Authors:	Tsybovsky, Y, Kwong, P.D, Farci, P.
Deposit date:	2022-03-11
Release date:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants. Cell Rep, 41, 2022

7TZ0

Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin (Local refinement of FSR22 and RBD)
Descriptor:	DARPin FSR22, Spike glycoprotein
Authors:	Kwon, Y.D, Gorman, J, Kwong, P.D.
Deposit date:	2022-02-15
Release date:	2022-12-07
Last modified:	2023-03-15
Method:	ELECTRON MICROSCOPY (4.17 Å)
Cite:	A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023

7TYZ

Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DARPin FSR22, ...
Authors:	Kwon, Y.D, Gorman, J, Kwong, P.D.
Deposit date:	2022-02-15
Release date:	2022-12-07
Last modified:	2023-03-15
Method:	ELECTRON MICROSCOPY (3.51 Å)
Cite:	A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19, 2023

7UFQ

Structure of PfCSP peptide 21 with antibody P3-43
Descriptor:	GLYCEROL, P3-43 Fab Heavy chain, P3-43 Fab Light chain, ...
Authors:	Tripathi, P, Kwong, P.D.
Deposit date:	2022-03-23
Release date:	2023-04-12
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structure of PfCSP peptide 21 with antibody P3-43 To Be Published

7UR6

Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ...
Authors:	Gorman, J, Kwong, P.D.
Deposit date:	2022-04-21
Release date:	2023-04-26
Method:	ELECTRON MICROSCOPY (3.46 Å)
Cite:	Cryo-EM structure of SHIV-elicited, FP-directed Rhesus Fab RM6561.DH1021.14 in complex with stabilized HIV-1 Env Ce1176 DS-SOSIP.664 To Be Published

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