8WCF
 
 | | Crystal structure of EcThsB | | Descriptor: | Molecular chaperone Tir, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2023-09-12 | | Release date: | 2024-09-18 | | Last modified: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Self-association activates ThsB NAD + hydrolase for defense against phage infection.
Biochem.Biophys.Res.Commun., 776, 2025
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8WC0
 | | Crystal structure of EcThsA | | Descriptor: | GLYCEROL, NAD(+) hydrolase ThsA, SODIUM ION, ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2023-09-11 | | Release date: | 2024-09-18 | | Last modified: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.249 Å) | | Cite: | Self-association activates ThsB NAD + hydrolase for defense against phage infection.
Biochem.Biophys.Res.Commun., 776, 2025
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8J4U
 | | Structure of HerA-Sir2 complex from Escherichia coli Nezha system | | Descriptor: | MAGNESIUM ION, Nucleoside triphosphate hydrolase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2023-04-20 | | Release date: | 2024-01-03 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Multiple enzymatic activities of a Sir2-HerA system cooperate for anti-phage defense.
Mol.Cell, 83, 2023
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6LP7
 | | Crystal structure of human DHODH in complex with inhibitor 0944 | | Descriptor: | 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2020-01-09 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6LP6
 | | Crystal structure of human DHODH in complex with inhibitor 1214 | | Descriptor: | 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2020-01-09 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.795 Å) | | Cite: | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6LP8
 | | Crystal structure of human DHODH in complex with inhibitor 1243 | | Descriptor: | 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2020-01-09 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6KNZ
 | | Crystal structure of T2R-TTL-KXO1 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, CALCIUM ION, ... | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2019-08-07 | | Release date: | 2019-10-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.475 Å) | | Cite: | Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.
J.Biol.Chem., 294, 2019
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8ZGI
 | | Crystal structure of DUF4297 from E.Coli | | Descriptor: | Restriction endonuclease | | Authors: | Chen, Q, Yu, Y. | | Deposit date: | 2024-05-09 | | Release date: | 2025-03-12 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection.
Mol.Cell, 85, 2025
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8JKH
 | | CryoEM structure of sNS1 complexed with Fab 4B8 | | Descriptor: | NS1, the heavy chain of antibody 4B8, the light chain of antibody 4B8 | | Authors: | Chen, Q, Pan, Q. | | Deposit date: | 2023-06-01 | | Release date: | 2024-12-04 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQS
 | | CryoEM structure of sNS1 complexed with Fab 14G5 | | Descriptor: | 14G5 Fab Heavy Chain, 14G5 Fab Light Chain, Non-structural protein 1 | | Authors: | Chen, Q, Pan, Q. | | Deposit date: | 2023-06-14 | | Release date: | 2024-12-04 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQN
 | | CryoEM structure of sNS1 complexed with Fab 2E11 | | Descriptor: | 2E11 Fab Heavy Chain, 2E11 Fab Light Chain, Non-structural protein 1 | | Authors: | Chen, Q, Qi, P. | | Deposit date: | 2023-06-14 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JKF
 | | CryoEM structure of sNS1 complexed with Fab 3G2 | | Descriptor: | NS1, the heavy chain of antibody 3G2, the light chain of antibody 3G2 | | Authors: | Chen, Q, Qi, P. | | Deposit date: | 2023-06-01 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQM
 | | CryoEM structure of sNS1 complexed with Fab 4F10 | | Descriptor: | 4F10 Fab Heavy Chain, 4F10 Fab Light Chain, Non-structural protein 1 | | Authors: | Chen, Q, Qi, P. | | Deposit date: | 2023-06-14 | | Release date: | 2024-12-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8X4C
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8X4B
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8X4A
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8X49
 | | Cryo-EM structure of Ryanodine receptor 1 (100 nM Ca2+) | | Descriptor: | CALCIUM ION, Ryanodine receptor 1, ZINC ION | | Authors: | Chen, Q, Hu, H. | | Deposit date: | 2023-11-15 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca 2+ /ATP.
Nat Commun, 16, 2025
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8X4D
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8X48
 | | Cryo-EM structure of Ryanodine receptor 1 (EGTA) | | Descriptor: | Ryanodine receptor 1 | | Authors: | Chen, Q, Hu, H. | | Deposit date: | 2023-11-15 | | Release date: | 2025-03-05 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural insights into transmembrane helix S0 facilitated RyR1 channel gating by Ca 2+ /ATP.
Nat Commun, 16, 2025
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8X4E
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3Q5Y
 | | V beta/V beta homodimerization-based pre-TCR model suggested by TCR beta crystal structures | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Chen, Q, Zhang, H, Wang, J.-H. | | Deposit date: | 2010-12-30 | | Release date: | 2011-03-09 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A conserved hydrophobic patch on Vbeta domains revealed by TCRbeta chain crystal structures: implications for pre-TCR dimerization
Front Immunol, 2, 2011
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3Q5T
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3EAO
 | | Crystal structure of recombinant rat selenoprotein thioredoxin reductase 1 with oxidized C-terminal tail | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1, ... | | Authors: | Sandalova, T, Cheng, Q, Lindqvist, Y, Arner, E. | | Deposit date: | 2008-08-26 | | Release date: | 2008-12-02 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.
J.Biol.Chem., 284, 2009
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3EAN
 | | Crystal structure of recombinant rat selenoprotein thioredoxin reductase 1 with reduced C-terminal tail | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1 | | Authors: | Sandalova, T, Cheng, Q, Lindqvist, Y, Arner, E. | | Deposit date: | 2008-08-26 | | Release date: | 2008-12-02 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.
J.Biol.Chem., 284, 2009
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7RPM
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