6VT2
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6VS7
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![BU of 6vs7 by Molmil](/molmil-images/mine/6vs7) | Sialic acid binding region of Streptococcus Sanguinis SK1 adhesin | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Adhesin, ... | Authors: | Stubbs, H.E, Iverson, T.M. | Deposit date: | 2020-02-10 | Release date: | 2020-08-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects. J.Biol.Chem., 295, 2020
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6W3H
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![BU of 6w3h by Molmil](/molmil-images/mine/6w3h) | Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1 | Authors: | Srivastava, A, Kariolis, M, Wells, R. | Deposit date: | 2020-03-09 | Release date: | 2020-06-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Sci Transl Med, 12, 2020
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6VLC
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3R9X
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![BU of 3r9x by Molmil](/molmil-images/mine/3r9x) | Crystal structure of Era in complex with MgGDPNP, nucleotides 1506-1542 of 16S ribosomal RNA, and KsgA | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, GTPase Era, ... | Authors: | Tu, C, Ji, X. | Deposit date: | 2011-03-26 | Release date: | 2011-06-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA. Proc.Natl.Acad.Sci.USA, 108, 2011
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6TYO
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![BU of 6tyo by Molmil](/molmil-images/mine/6tyo) | Salmonella Typhi PltB Homopentamer with Neu-5NAc-4OAc-alpha-2-3-Gal-beta-1-4-GlcNAc Glycans | Descriptor: | 4-O-acetyl-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertussis-like toxin subunit | Authors: | Nguyen, T, Milano, S.K, Yang, Y.A, Song, J. | Deposit date: | 2019-08-09 | Release date: | 2020-02-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | The role of 9-O-acetylated glycan receptor moieties in the typhoid toxin binding and intoxication. Plos Pathog., 16, 2020
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6VVU
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![BU of 6vvu by Molmil](/molmil-images/mine/6vvu) | Anti-Tryptase fab E104.v1 bound to tryptase | Descriptor: | CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... | Authors: | Ultsch, M, Koerber, J.T. | Deposit date: | 2020-02-18 | Release date: | 2020-12-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge. Nat Commun, 11, 2020
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6VU6
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8EBU
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![BU of 8ebu by Molmil](/molmil-images/mine/8ebu) | XPC release from Core7-XPA-DNA (Cy5) | Descriptor: | DNA repair protein complementing XP-A cells, DNA repair protein complementing XP-C cells, DNA1, ... | Authors: | Kim, J, Yang, W. | Deposit date: | 2022-08-31 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
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8EBS
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8EBT
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8EBY
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![BU of 8eby by Molmil](/molmil-images/mine/8eby) | XPC release from Core7-XPA-DNA (AP) | Descriptor: | DNA, DNA repair protein complementing XP-A cells, DNA repair protein complementing XP-C cells, ... | Authors: | Kim, J, Yang, W. | Deposit date: | 2022-08-31 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Lesion recognition by XPC, TFIIH and XPA in DNA excision repair. Nature, 617, 2023
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8EBV
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8EBW
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8EBX
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5IHC
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![BU of 5ihc by Molmil](/molmil-images/mine/5ihc) | MELK in complex with NVS-MELK12B | Descriptor: | 4-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine, Maternal embryonic leucine zipper kinase | Authors: | Sprague, E.R, Brazell, T. | Deposit date: | 2016-02-29 | Release date: | 2016-06-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
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1X18
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![BU of 1x18 by Molmil](/molmil-images/mine/1x18) | Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT | Descriptor: | 30S ribosomal protein S11, 30S ribosomal protein S18, 30S ribosomal protein S2, ... | Authors: | Sharma, M.R, Barat, C, Agrawal, R.K. | Deposit date: | 2005-04-02 | Release date: | 2005-05-17 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (13.5 Å) | Cite: | Interaction of Era with the 30S Ribosomal Subunit Implications for 30S Subunit Assembly Mol.Cell, 18, 2005
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1X1L
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![BU of 1x1l by Molmil](/molmil-images/mine/1x1l) | Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit. | Descriptor: | GTP-binding protein era, RNA (130-MER) | Authors: | Sharma, M.R, Barat, C, Agrawal, R.K. | Deposit date: | 2005-04-06 | Release date: | 2005-05-17 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (13.5 Å) | Cite: | Interaction of Era with the 30S Ribosomal Subunit Implications for 30S Subunit Assembly Mol.Cell, 18, 2005
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5IH8
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![BU of 5ih8 by Molmil](/molmil-images/mine/5ih8) | MELK in complex with NVS-MELK1 | Descriptor: | Maternal embryonic leucine zipper kinase, N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide | Authors: | Sprague, E.R, Puleo, D.E. | Deposit date: | 2016-02-29 | Release date: | 2016-06-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
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7ZWB
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![BU of 7zwb by Molmil](/molmil-images/mine/7zwb) | human Carbonic Anhydrase II in complex with 4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)thio)benzenesulfonamide | Descriptor: | 4-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanylbenzenesulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Angeli, A, Ferraroni, M. | Deposit date: | 2022-05-19 | Release date: | 2023-05-31 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. J.Med.Chem., 66, 2023
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8A8N
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8A7I
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![BU of 8a7i by Molmil](/molmil-images/mine/8a7i) | Crystal structure of BRD9 bromodomain in complex with compound EA-89 | Descriptor: | Bromodomain-containing protein 9, ~{N}-[1,1-bis(oxidanylidene)thian-4-yl]-7-[3-methyl-1-(piperidin-4-ylmethyl)indol-5-yl]-4-oxidanylidene-5-propyl-thieno[3,2-c]pyridine-2-carboxamide | Authors: | Faller, M, Zink, F. | Deposit date: | 2022-06-21 | Release date: | 2022-08-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma. Blood Cancer J, 12, 2022
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7WUE
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![BU of 7wue by Molmil](/molmil-images/mine/7wue) | Crystal structure of SARS-CoV-2 Receptor Binding Domain in complex with the monoclonal antibody m31A7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mohapatra, A. | Deposit date: | 2022-02-08 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models. Sci Transl Med, 14, 2022
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4FA8
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![BU of 4fa8 by Molmil](/molmil-images/mine/4fa8) | Multi-pronged modulation of cytokine signaling | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage colony-stimulating factor 1, Secreted protein BARF1, ... | Authors: | He, X, Shim, A.H. | Deposit date: | 2012-05-21 | Release date: | 2012-08-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1. Proc.Natl.Acad.Sci.USA, 109, 2012
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5IH9
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![BU of 5ih9 by Molmil](/molmil-images/mine/5ih9) | MELK in complex with NVS-MELK8A | Descriptor: | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine, Maternal embryonic leucine zipper kinase | Authors: | Sprague, E.R, Puleo, D.E. | Deposit date: | 2016-02-29 | Release date: | 2016-06-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J.Med.Chem., 59, 2016
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