7ZWB

human Carbonic Anhydrase II in complex with 4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)thio)benzenesulfonamide

This is a non-PDB format compatible entry.

Summary for 7ZWB

• Entry DOI: 10.2210/pdb7zwb/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 4-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanylbenzenesulfonamide, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase, inhibitor, metalloenzyme, sulfonamide, glucose, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 30057.26

Authors

Angeli, A.,Ferraroni, M. (deposition date: 2022-05-19, release date: 2023-05-31, Last modification date: 2024-06-12)

• Primary citation: Angeli, A.,Ferraroni, M.,Granchi, C.,Minutolo, F.,Chen, X.,Shriwas, P.,Russo, E.,Leo, A.,Selleri, S.,Carta, F.,Supuran, C.T.; First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome.; J.Med.Chem., 66:10010-10026, 2023; PubMed: 37436184; DOI: 10.1021/acs.jmedchem.3c00938

Experimental method

X-RAY DIFFRACTION (1.48 Å)