8A7I

Crystal structure of BRD9 bromodomain in complex with compound EA-89

Summary for 8A7I

• Entry DOI: 10.2210/pdb8a7i/pdb
• Descriptor: Bromodomain-containing protein 9, ~{N}-[1,1-bis(oxidanylidene)thian-4-yl]-7-[3-methyl-1-(piperidin-4-ylmethyl)indol-5-yl]-4-oxidanylidene-5-propyl-thieno[3,2-c]pyridine-2-carboxamide (3 entities in total)
• Functional Keywords: bromodomain, brd9, inhibitor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 27321.91

Authors

Faller, M.,Zink, F. (deposition date: 2022-06-21, release date: 2022-08-10, Last modification date: 2024-01-31)

• Primary citation: Weisberg, E.,Chowdhury, B.,Meng, C.,Case, A.E.,Ni, W.,Garg, S.,Sattler, M.,Azab, A.K.,Sun, J.,Muz, B.,Sanchez, D.,Toure, A.,Stone, R.M.,Galinsky, I.,Winer, E.,Gleim, S.,Gkountela, S.,Kedves, A.,Harrington, E.,Abrams, T.,Zoller, T.,Vaupel, A.,Manley, P.,Faller, M.,Chung, B.,Chen, X.,Busenhart, P.,Stephan, C.,Calkins, K.,Bonenfant, D.,Thoma, C.R.,Forrester, W.,Griffin, J.D.; BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma.; Blood Cancer J, 12:110-110, 2022; PubMed: 35853853; DOI: 10.1038/s41408-022-00704-7

Experimental method

X-RAY DIFFRACTION (1.76 Å)