8A7I
Crystal structure of BRD9 bromodomain in complex with compound EA-89
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 9 | polymer | 113 | 13066.2 | 2 | UniProt (Q9H8M2) Pfam (PF00439) In PDB | Homo sapiens (human) | Rhabdomyosarcoma antigen MU-RMS-40.8 |
| 2 | A, B | ~{N}-[1,1-bis(oxidanylidene)thian-4-yl]-7-[3-methyl-1-(piperidin-4-ylmethyl)indol-5-yl]-4-oxidanylidene-5-propyl-thieno[3,2-c]pyridine-2-carboxamide | non-polymer | 594.8 | 2 | Chemie (L8L) | |||
| 3 | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 240 (UniProt: Q9H8M2)
| PDB | External Database | Details |
|---|---|---|
| Gly 128 | - | expression tag |
| Pro 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26132.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1189.6 | |
| All* | Total formula weight | 27321.9 |
