4O2A
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![BU of 4o2a by Molmil](/molmil-images/mine/4o2a) | Tubulin-BAL27862 complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | Deposit date: | 2013-12-17 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
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4PWS
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![BU of 4pws by Molmil](/molmil-images/mine/4pws) | Crystal structure of secreted proline rich antigen MTC28 (Rv0040c) at 2.15 A with bound chloride from Mycobacterium tuberculosis | Descriptor: | CHLORIDE ION, Proline-rich 28 kDa antigen | Authors: | Kundu, P, Biswas, R, Mukherjee, S, Reinhard, L, Mueller-dieckmann, J, Weiss, M.S, Das, A.K. | Deposit date: | 2014-03-21 | Release date: | 2015-03-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-based Epitope Mapping of Mycobacterium tuberculosis Secretary Antigen MTC28 J.Biol.Chem., 291, 2016
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3RKR
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![BU of 3rkr by Molmil](/molmil-images/mine/3rkr) | Crystal structure of a metagenomic short-chain oxidoreductase (SDR) in complex with NADP | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, Short chain oxidoreductase | Authors: | Mayerhofer, H, Bijtenhoorn, P, Streit, W.R, Mueller-Dieckmann, J. | Deposit date: | 2011-04-18 | Release date: | 2011-11-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. Plos One, 6, 2011
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6RTR
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![BU of 6rtr by Molmil](/molmil-images/mine/6rtr) | Piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus | Descriptor: | ACETATE ION, GLYCEROL, SULFATE ION, ... | Authors: | Hasse, D, Huelsemann, J, Carlsson, G, Andersson, I. | Deposit date: | 2019-05-26 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus. Acta Crystallogr D Struct Biol, 75, 2019
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1I2G
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![BU of 1i2g by Molmil](/molmil-images/mine/1i2g) | Ribonuclease T1 V16T mutant | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1 | Authors: | De Vos, S, Backmann, J, Steyaert, J, Loris, R. | Deposit date: | 2001-02-09 | Release date: | 2001-03-07 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Hydrophobic core manipulations in ribonuclease T1 Biochemistry, 40, 2001
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6SDX
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![BU of 6sdx by Molmil](/molmil-images/mine/6sdx) | Salmonella ATPase InvC with ATP gamma S | Descriptor: | ATP synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Bernal, I, Roemermann, J, Flacht, L, Lunelli, M, Uetrecht, C, Kolbe, M. | Deposit date: | 2019-07-29 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.645 Å) | Cite: | Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci., 28, 2019
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5CTW
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![BU of 5ctw by Molmil](/molmil-images/mine/5ctw) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(butanoylamino)thiophene-3-carboxamide, CHLORIDE ION, ... | Authors: | Andersen, O.A, Barker, J, Hadfield, A.T, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | Deposit date: | 2015-07-24 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26, 2016
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5CTX
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![BU of 5ctx by Molmil](/molmil-images/mine/5ctx) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-phenyl-3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, DNA gyrase subunit B, ... | Authors: | Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | Deposit date: | 2015-07-24 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26, 2016
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5CPH
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![BU of 5cph by Molmil](/molmil-images/mine/5cph) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | Descriptor: | (3E)-3-(pyridin-3-ylmethylidene)-1,3-dihydro-2H-indol-2-one, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA gyrase subunit B, ... | Authors: | Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | Deposit date: | 2015-07-21 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26, 2016
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6RAE
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![BU of 6rae by Molmil](/molmil-images/mine/6rae) | Structural analysis of the Salmonella type III secretion system ATPase InvC | Descriptor: | CHLORIDE ION, GLYCEROL, Secretory apparatus ATP synthase (Associated with virulence) | Authors: | Bernal, I, Roemermann, J, Flacht, L, Lunelli, M, Uetrecht, C, Kolbe, M. | Deposit date: | 2019-04-05 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci., 28, 2019
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6RAD
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![BU of 6rad by Molmil](/molmil-images/mine/6rad) | Salmonella ATPase InvC with ADP | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Bernal, I, Roemermann, J, Flacht, L, Lunelli, M, Uetrecht, C, Kolbe, M. | Deposit date: | 2019-04-05 | Release date: | 2019-08-21 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.796 Å) | Cite: | Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci., 28, 2019
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3I4O
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![BU of 3i4o by Molmil](/molmil-images/mine/3i4o) | |
1I3I
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![BU of 1i3i by Molmil](/molmil-images/mine/1i3i) | Ribonuclease T1 V78T mutant | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1 | Authors: | De Vos, S, Backmann, J, Steyaert, J, Loris, R. | Deposit date: | 2001-02-15 | Release date: | 2001-03-07 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Hydrophobic core manipulations in ribonuclease T1 Biochemistry, 40, 2001
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1I2F
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![BU of 1i2f by Molmil](/molmil-images/mine/1i2f) | Ribonuclease T1 V16A mutant, form II | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1 | Authors: | De Vos, S, Backmann, J, Steyaert, J, Loris, R. | Deposit date: | 2001-02-09 | Release date: | 2001-03-07 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Hydrophobic core manipulations in ribonuclease T1 Biochemistry, 40, 2001
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1I3F
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![BU of 1i3f by Molmil](/molmil-images/mine/1i3f) | Ribonuclease T1 V89S mutant | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1 | Authors: | De Vos, S, Backmann, J, Steyaert, J, Loris, R. | Deposit date: | 2001-02-15 | Release date: | 2001-03-07 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Hydrophobic core manipulations in ribonuclease T1 Biochemistry, 40, 2001
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5CTU
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![BU of 5ctu by Molmil](/molmil-images/mine/5ctu) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4(1H)-one, CHLORIDE ION, ... | Authors: | Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | Deposit date: | 2015-07-24 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26, 2016
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1HW7
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![BU of 1hw7 by Molmil](/molmil-images/mine/1hw7) | HSP33, HEAT SHOCK PROTEIN WITH REDOX-REGULATED CHAPERONE ACTIVITY | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HEAT SHOCK PROTEIN HSP33, SULFATE ION, ... | Authors: | Vijayalakshmi, J, Mukhergee, M.K, Graumann, J, Jakob, U, Saper, M.A. | Deposit date: | 2001-01-09 | Release date: | 2001-05-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity. Structure, 9, 2001
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5CTY
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![BU of 5cty by Molmil](/molmil-images/mine/5cty) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a fragment | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, CHLORIDE ION, ... | Authors: | Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C, Mesleh, M, Cross, J.B, Zhang, J, Yang, Q, Lippa, B, Ryan, M.D. | Deposit date: | 2015-07-24 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorg.Med.Chem.Lett., 26, 2016
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6RTS
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![BU of 6rts by Molmil](/molmil-images/mine/6rts) | Piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus complexed with NAD+ | Descriptor: | ACETATE ION, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Hasse, D, Huelsemann, J, Carlsson, G, Andersson, I. | Deposit date: | 2019-05-26 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus. Acta Crystallogr D Struct Biol, 75, 2019
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6RTT
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![BU of 6rtt by Molmil](/molmil-images/mine/6rtt) | Piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus complexed with picolinic acid | Descriptor: | GLYCEROL, PYRIDINE-2-CARBOXYLIC ACID, SULFATE ION, ... | Authors: | Hasse, D, Huelsemann, J, Carlsson, G, Andersson, I. | Deposit date: | 2019-05-26 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus. Acta Crystallogr D Struct Biol, 75, 2019
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1I2E
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![BU of 1i2e by Molmil](/molmil-images/mine/1i2e) | Ribonuclease T1 V16A mutant, form I | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1 | Authors: | De Vos, S, Backmann, J, Steyaert, J, Loris, R. | Deposit date: | 2001-02-09 | Release date: | 2001-03-07 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hydrophobic core manipulations in ribonuclease T1 Biochemistry, 40, 2001
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6RTU
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![BU of 6rtu by Molmil](/molmil-images/mine/6rtu) | Piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus complexed with alpha-aminoadipic acid | Descriptor: | 2-AMINOHEXANEDIOIC ACID, ACETATE ION, GLYCEROL, ... | Authors: | Hasse, D, Huelsemann, J, Carlsson, G, Andersson, I. | Deposit date: | 2019-05-26 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus. Acta Crystallogr D Struct Biol, 75, 2019
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3HFW
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![BU of 3hfw by Molmil](/molmil-images/mine/3hfw) | Crystal Structure of human ADP-ribosylhydrolase 1 (hARH1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Mueller-Dieckmann, C, Weiss, M.S, Mueller-Dieckmann, J, Koch-Nolte, F. | Deposit date: | 2009-05-13 | Release date: | 2010-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal Structure of human ADP-ribosylhydrolase 1 To be Published
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1W2K
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![BU of 1w2k by Molmil](/molmil-images/mine/1w2k) | tf7a_4380 complex | Descriptor: | (2R)-2-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO)-N-BENZYL-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE, BLOOD COAGULATION FACTOR VIIA, CACODYLATE ION, ... | Authors: | Banner, D.W, D'Arcy, A, Groebke-Zbinden, K, Ackermann, J, Kirchhofer, D, Ji, Y.-H, Tschopp, T.B, Wallbaum, S, Weber, L. | Deposit date: | 2004-07-06 | Release date: | 2005-06-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
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1W0Y
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![BU of 1w0y by Molmil](/molmil-images/mine/1w0y) | tf7a_3771 complex | Descriptor: | 4-(4-BENZYLOXY-2-METHANESULFONYLAMINO-5-METHOXY-BENZYLAMINO)-BENZAMIDINE, BLOOD COAGULATION FACTOR VIIA, CACODYLATE ION, ... | Authors: | Banner, D.W, D'Arcy, A, Groebke-Zbinden, K, Ackermann, J, Kirchhofer, D, Ji, Y.-H, Tschopp, T.B, Wallbaum, S, Weber, L. | Deposit date: | 2004-05-27 | Release date: | 2005-01-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
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