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7EHM
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BU of 7ehm by Molmil
Human MTHFD2 in complex with compound 21 and 15
Descriptor: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, (2S)-2-[[4-[[1-[(3,4-dichlorophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]amino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ...
Authors:Lee, L.C, Peng, Y.H, Wu, S.Y.
Deposit date:2021-03-30
Release date:2021-08-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
J.Med.Chem., 64, 2021
7EHV
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BU of 7ehv by Molmil
Human MTHFD2 in complex with compound 21 and 3
Descriptor: (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 1-(3,4-dichlorobenzyl)-8-(((1R,4R)-4-hydroxycyclohexyl)amino)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ...
Authors:Lee, L.C, Peng, Y.H, Wu, S.Y.
Deposit date:2021-03-30
Release date:2021-08-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
J.Med.Chem., 64, 2021
7BBD
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BU of 7bbd by Molmil
Crystal structure of monoubiquitinated TRIM21 RING (Ub-RING) In complex with ubiquitin charged Ube2N (Ube2N~Ub) and Ube2V2
Descriptor: Polyubiquitin-B,E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Kiss, L, Neuhaus, D, James, L.C.
Deposit date:2020-12-17
Release date:2021-01-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
6S53
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BU of 6s53 by Molmil
Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ...
Authors:Kiss, L, Boland, A, Neuhaus, D, James, L.C.
Deposit date:2019-06-30
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Nat Commun, 10, 2019
6RSS
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BU of 6rss by Molmil
Solution structure of the fourth WW domain of WWP2 with GB1-tag
Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP2
Authors:Wahl, L.C, Watt, J.E, Tolchard, J, Blumenschein, T.M.A, Chantry, A.
Deposit date:2019-05-22
Release date:2019-10-09
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms.
Int J Mol Sci, 20, 2019
6R8C
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BU of 6r8c by Molmil
HIV capsid hexamer with IP5 ligand
Descriptor: Gag polyprotein, MYO-INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE
Authors:James, L.C.
Deposit date:2019-04-01
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:HIV hexamer
to be published
6R2U
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BU of 6r2u by Molmil
Zinc-alpha2-Glycoprotein with a Fluorescent Dansyl C 11 Fatty Acid
Descriptor: 11-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)undecanoic acid, AZIDE ION, SULFATE ION, ...
Authors:Lau, A.M, Gor, J, Perkins, S.J, Coker, A.R, McDermott, L.C.
Deposit date:2019-03-18
Release date:2019-09-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of zinc-alpha 2-glycoprotein in complex with a fatty acid reveals multiple different modes of protein-lipid binding.
Biochem.J., 476, 2019
7BBF
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BU of 7bbf by Molmil
Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Kiss, L, Neuhaus, D, James, L.C.
Deposit date:2020-12-17
Release date:2021-01-27
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Nat Commun, 12, 2021
8A58
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BU of 8a58 by Molmil
X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W
Descriptor: E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 W, ZINC ION
Authors:James, L.C, Kiss, L.
Deposit date:2022-06-14
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Nat Commun, 14, 2023
8DB4
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BU of 8db4 by Molmil
Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1
Descriptor: 1,2-ETHANEDIOL, 13T1 Heavy chain, 13T1 Light chain, ...
Authors:Min, J, Pedersen, L.C.
Deposit date:2022-06-14
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy.
J.Clin.Invest., 133, 2023
8DFU
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BU of 8dfu by Molmil
Cryo-EM structure of conjugation pili from Aeropyrum pernix
Descriptor: (2S)-3-{[(3R,7S,11S,15S)-3,7,11,15,19-pentamethylicosyl]oxy}-2-{[(2R,6S,10S,14R)-2,6,10,14,18-pentamethylnonadecyl]oxy}propyl dihydrogen phosphate, Pilin protein
Authors:Beltran, L.C, Egelman, E.H.
Deposit date:2022-06-22
Release date:2023-03-22
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery.
Nat Commun, 14, 2023
8DFT
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BU of 8dft by Molmil
Cryo-EM structure of conjugative pili from Pyrobaculum calidifontis
Descriptor: Pilin protein, [(2~{S},7~{S},11~{S},15~{S},19~{R},22~{R},26~{S},30~{R},34~{R},38~{S},43~{S},47~{S},51~{S},55~{R},58~{R},62~{S},66~{R},70~{R})-38-(hydroxymethyl)-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methanol
Authors:Beltran, L.C, Egelman, E.H.
Deposit date:2022-06-22
Release date:2023-03-22
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery.
Nat Commun, 14, 2023
1UBV
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BU of 1ubv by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
Descriptor: FARNESYL DIPHOSPHATE SYNTHASE
Authors:Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
Deposit date:1996-10-14
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBW
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BU of 1ubw by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
Descriptor: FARNESYL DIPHOSPHATE SYNTHASE, GERANYL DIPHOSPHATE, MAGNESIUM ION
Authors:Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
Deposit date:1996-10-14
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBX
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BU of 1ubx by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
Descriptor: FARNESYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION
Authors:Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
Deposit date:1996-10-14
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBY
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BU of 1uby by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
Descriptor: DIMETHYLALLYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION
Authors:Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
Deposit date:1996-10-14
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
8E37
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BU of 8e37 by Molmil
Structure of Campylobacter concisus wild-type SeMet PglC
Descriptor: N,N'-diacetylbacilliosaminyl-1-phosphate transferase
Authors:Vuksanovic, N, Ray, L.C, Imperiali, B, Allen, K.N.
Deposit date:2022-08-16
Release date:2023-09-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble.
J.Biol.Chem., 299, 2023
8EXH
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BU of 8exh by Molmil
Agrobacterium tumefaciens Tpilus
Descriptor: (14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2
Authors:Beltran, L.C, Egelman, E.H.
Deposit date:2022-10-25
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery
Nat Commun, 14, 2023
8EPU
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BU of 8epu by Molmil
1.6 A crystal structure of the lipocalin dog allergen Can f 1 with the C118S mutation
Descriptor: Major allergen Can f 1
Authors:Min, J, Pedersen, L.C, Geoffrey, M.A.
Deposit date:2022-10-06
Release date:2023-04-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and ligand binding analysis of the pet allergens Can f 1 and Fel d 7.
Front Allergy, 4, 2023
8EPV
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BU of 8epv by Molmil
2.2 A crystal structure of the lipocalin cat allergen Fel d 7
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Fel d 7 allergen, ...
Authors:Min, J, Pedersen, L.C, Geoffrey, M.A.
Deposit date:2022-10-06
Release date:2023-04-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural and ligand binding analysis of the pet allergens Can f 1 and Fel d 7.
Front Allergy, 4, 2023
1XSL
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BU of 1xsl by Molmil
Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap
Descriptor: 5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSP
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BU of 1xsp by Molmil
Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate
Descriptor: 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSN
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BU of 1xsn by Molmil
Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP
Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', ...
Authors:Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Kunkel, T.A, Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
4LZT
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BU of 4lzt by Molmil
ATOMIC RESOLUTION REFINEMENT OF TRICLINIC HEW LYSOZYME AT 295K
Descriptor: LYSOZYME, NITRATE ION
Authors:Walsh, M.A, Schneider, T, Sieker, L.C, Dauter, Z, Lamzin, V, Wilson, K.S.
Deposit date:1997-03-31
Release date:1998-04-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Refinement of triclinic hen egg-white lysozyme at atomic resolution.
Acta Crystallogr.,Sect.D, 54, 1998
6D7N
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BU of 6d7n by Molmil
Crystal structure of the W357R/W399R Importin alpha mutant
Descriptor: 1,2-ETHANEDIOL, Peroxidase,Importin subunit alpha-1
Authors:Pedersen, L.C, London, R.E, Gabel, S.A.
Deposit date:2018-04-25
Release date:2019-03-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018

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