1SVR
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![BU of 1svr by Molmil](/molmil-images/mine/1svr) | |
1TLE
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![BU of 1tle by Molmil](/molmil-images/mine/1tle) | LE (LAMININ-TYPE EGF-LIKE) MODULE GIII4 IN SOLUTION AT PH 3.5 AND 290 K, NMR, 14 STRUCTURES | Descriptor: | LAMININ | Authors: | Baumgartner, R, Czisch, M, Mayer, U, Schl, E.P, Huber, R, Timpl, R, Holak, T.A. | Deposit date: | 1996-01-26 | Release date: | 1997-02-12 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structure of the nidogen binding LE module of the laminin gamma1 chain in solution. J.Mol.Biol., 257, 1996
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1OXD
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![BU of 1oxd by Molmil](/molmil-images/mine/1oxd) | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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1OXE
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![BU of 1oxe by Molmil](/molmil-images/mine/1oxe) | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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1OH1
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![BU of 1oh1 by Molmil](/molmil-images/mine/1oh1) | Solution structure of staphostatin A form Staphylococcus aureus confirms the discovery of a novel class of cysteine proteinase inhibitors. | Descriptor: | STAPHOSTATIN A | Authors: | Dubin, G, Popowicz, G, Krajewski, M, Stec, J, Bochtler, M, Potempa, J, Dubin, A, Holak, T.A. | Deposit date: | 2003-05-21 | Release date: | 2003-11-20 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | A Novel Class of Cysteine Protease Inhibitors: Solution Structure of Staphostatin a from Staphylococcus Aureus Biochemistry, 42, 2003
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1QLO
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![BU of 1qlo by Molmil](/molmil-images/mine/1qlo) | Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy | Descriptor: | HERPES SIMPLEX VIRUS PROTEIN ICP47 | Authors: | Pfaender, R, Neumann, L, Zweckstetter, M, Seger, C, Holak, T.A, Tampe, R. | Deposit date: | 1999-09-09 | Release date: | 1999-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Structure of the Active Domain of the Herpes Simplex Virus Protein Icp47 in Water/Sodium Dodecyl Sulfate Solution Determined by Nuclear Magnetic Resonance Spectroscopy. Biochemistry, 38, 1999
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1NMG
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![BU of 1nmg by Molmil](/molmil-images/mine/1nmg) | |
1NMF
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1NPS
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![BU of 1nps by Molmil](/molmil-images/mine/1nps) | CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PROTEIN S | Descriptor: | CALCIUM ION, DEVELOPMENT-SPECIFIC PROTEIN S | Authors: | Wenk, M, Baumgartner, R, Mayer, E.M, Huber, R, Holak, T.A, Jaenicke, R. | Deposit date: | 1999-02-01 | Release date: | 2000-02-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The domains of protein S from Myxococcus xanthus: structure, stability and interactions. J.Mol.Biol., 286, 1999
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1OXF
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![BU of 1oxf by Molmil](/molmil-images/mine/1oxf) | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | Descriptor: | cyan fluorescent protein cfp | Authors: | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | Deposit date: | 2003-04-02 | Release date: | 2003-12-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins J.Mol.Biol., 328, 2003
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1A23
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![BU of 1a23 by Molmil](/molmil-images/mine/1a23) | SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, MINIMIZED AVERAGE STRUCTURE | Descriptor: | DSBA | Authors: | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | Deposit date: | 1998-01-15 | Release date: | 1998-09-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of reduced DsbA from Escherichia coli in solution. Biochemistry, 37, 1998
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1A24
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![BU of 1a24 by Molmil](/molmil-images/mine/1a24) | SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, FAMILY OF 20 STRUCTURES | Descriptor: | DSBA | Authors: | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | Deposit date: | 1998-01-15 | Release date: | 1998-09-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of reduced DsbA from Escherichia coli in solution. Biochemistry, 37, 1998
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1AG4
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![BU of 1ag4 by Molmil](/molmil-images/mine/1ag4) | NMR STRUCTURE OF SPHERULIN 3A (S3A) FROM PHYSARUM POLYCEPHALUM, MINIMIZED AVERAGE STRUCTURE | Descriptor: | SPHERULIN 3A | Authors: | Rosinke, B, Renner, C, Mayr, E.-M, Jaenicke, R, Holak, T.A. | Deposit date: | 1997-04-01 | Release date: | 1998-04-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Ca2+-loaded spherulin 3a from Physarum polycephalum adopts the prototype gamma-crystallin fold in aqueous solution. J.Mol.Biol., 271, 1997
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1DTV
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![BU of 1dtv by Molmil](/molmil-images/mine/1dtv) | NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI) | Descriptor: | CARBOXYPEPTIDASE INHIBITOR | Authors: | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | Deposit date: | 2000-01-13 | Release date: | 2000-07-19 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. Nat.Struct.Biol., 7, 2000
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1DTD
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![BU of 1dtd by Molmil](/molmil-images/mine/1dtd) | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2) | Descriptor: | CARBOXYPEPTIDASE A2, GLUTAMIC ACID, METALLOCARBOXYPEPTIDASE INHIBITOR, ... | Authors: | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | Deposit date: | 2000-01-12 | Release date: | 2000-07-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. Nat.Struct.Biol., 7, 2000
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1BD8
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![BU of 1bd8 by Molmil](/molmil-images/mine/1bd8) | STRUCTURE OF CDK INHIBITOR P19INK4D | Descriptor: | P19INK4D CDK4/6 INHIBITOR | Authors: | Baumgartner, R, Fernandez-Catalan, C, Winoto, A, Huber, R, Engh, R, Holak, T.A. | Deposit date: | 1998-05-12 | Release date: | 1998-10-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure, 6, 1998
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1DNY
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![BU of 1dny by Molmil](/molmil-images/mine/1dny) | SOLUTION STRUCTURE OF PCP, A PROTOTYPE FOR THE PEPTIDYL CARRIER DOMAINS OF MODULAR PEPTIDE SYNTHETASES | Descriptor: | NON-RIBOSOMAL PEPTIDE SYNTHETASE PEPTIDYL CARRIER PROTEIN | Authors: | Weber, T, Baumgartner, R, Renner, C, Marahiel, M.A, Holak, T.A. | Deposit date: | 1999-12-17 | Release date: | 2000-05-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Structure Fold.Des., 8, 2000
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7BEA
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![BU of 7bea by Molmil](/molmil-images/mine/7bea) | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | Descriptor: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | Deposit date: | 2020-12-22 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists. Acs Med.Chem.Lett., 12, 2021
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7OUN
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![BU of 7oun by Molmil](/molmil-images/mine/7oun) | |
6R8G
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![BU of 6r8g by Molmil](/molmil-images/mine/6r8g) | Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine | Descriptor: | 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | Deposit date: | 2019-04-01 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity Commun Biol, 2021
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8ALX
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![BU of 8alx by Molmil](/molmil-images/mine/8alx) | Structure of human PD-L1 in complex with inhibitor | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, AMINOMETHYLAMIDE, ACETATE ION, ... | Authors: | Rodriguez, I, Grudnik, P, Holak, T, Magiera-Mularz, K. | Deposit date: | 2022-08-01 | Release date: | 2023-08-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies. Mol Cancer, 22, 2023
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8AEU
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![BU of 8aeu by Molmil](/molmil-images/mine/8aeu) | Structure of hMDM2 in complex with Nutlin-3a-aa | Descriptor: | 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2 | Authors: | Labuzek, B, Golik, P, Magiera-Mularz, K, Berg, T. | Deposit date: | 2022-07-13 | Release date: | 2023-01-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group. Chembiochem, 24, 2023
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8P64
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![BU of 8p64 by Molmil](/molmil-images/mine/8p64) | Co-crystal structure of PD-L1 with low molecular weight inhibitor | Descriptor: | Programmed cell death 1 ligand 1, ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine | Authors: | Plewka, J, Magiera-Mularz, K, van der Straat, R, Draijer, R, Surmiak, E, Butera, R, Land, L, Musielak, B, Domling, A. | Deposit date: | 2023-05-25 | Release date: | 2024-03-06 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.312 Å) | Cite: | 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists. Rsc Med Chem, 15, 2024
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8R6Q
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![BU of 8r6q by Molmil](/molmil-images/mine/8r6q) | Co-crystal structure of PD-L1 with low molecular weight inhibitor | Descriptor: | (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... | Authors: | Plewka, J, Surmiak, E, Magiera-Mularz, K, Kalinowska-Tluscik, J. | Deposit date: | 2023-11-22 | Release date: | 2024-01-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives. Acs Med.Chem.Lett., 15, 2024
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6Y91
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![BU of 6y91 by Molmil](/molmil-images/mine/6y91) | Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH | Descriptor: | Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | Deposit date: | 2020-03-06 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity. Commun Biol, 4, 2021
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