8ID9
| Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | Descriptor: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
8ID4
| Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | Descriptor: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
2K29
| |
8ID8
| Cryo-EM structure of the TUG891 bound GPR120-Gi complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
8ID3
| Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | Descriptor: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
8I2H
| Follicle stimulating hormone receptor | Descriptor: | Follicle-stimulating hormone receptor | Authors: | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | Deposit date: | 2023-01-14 | Release date: | 2023-03-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
|
|
8I2G
| FSHR-Follicle stimulating hormone-compound 716340-Gs complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Duan, J, Xu, P, Yang, J, Ji, Y, Zhang, H, Mao, C, Luan, X, Jiang, Y, Zhang, Y, Zhang, S, Xu, H.E. | Deposit date: | 2023-01-14 | Release date: | 2023-03-29 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nat Commun, 14, 2023
|
|
5HN7
| |
5HNA
| |
5HN8
| Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182 | Descriptor: | 2-{[3-hydroxy-5-(octyloxy)benzyl]sulfanyl}benzoic acid, Farnesyl pyrophosphate synthase, putative, ... | Authors: | Liu, Y.-L, Zhang, Y, Oldfield, E. | Deposit date: | 2016-01-18 | Release date: | 2016-09-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry, 55, 2016
|
|
5HN9
| |
2KC8
| Structure of E. coli toxin RelE (R81A/R83A) mutant in complex with antitoxin RelBc (K47-L79) peptide | Descriptor: | Antitoxin RelB, Toxin relE | Authors: | Li, G, Zhang, Y, Inouye, M, Ikura, M. | Deposit date: | 2008-12-17 | Release date: | 2009-03-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J.Biol.Chem., 284, 2009
|
|
2H2M
| |
2KC9
| |
5FBP
| CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH THE PRODUCT FRUCTOSE 6-PHOSPHATE AT 2.1-ANGSTROMS RESOLUTION | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Ke, H, Liang, J.-Y, Zhang, Y, Lipscomb, W.N. | Deposit date: | 1991-02-11 | Release date: | 1992-07-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the neutral form of fructose-1,6-bisphosphatase complexed with the product fructose 6-phosphate at 2.1-A resolution. Proc.Natl.Acad.Sci.USA, 88, 1991
|
|
7SGV
| Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder630 inhibitor | Descriptor: | CHLORIDE ION, N-(naphthalen-1-yl)pyridine-3-carboxamide, Papain-like protease, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Lisnyak, V, Maki, S, Taylor, C, Zhang, Y, Zhou, Z, Azizi, S.A, Jones, K, Kathayat, R, Snyder, S.A, Dickinson, B.C, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-10-07 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder630 inhibitor To Be Published
|
|
7SGU
| Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder608 inhibitor | Descriptor: | 5-amino-N-(naphthalen-1-yl)pyridine-3-carboxamide, CHLORIDE ION, FORMIC ACID, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Lisnyak, V, Maki, S, Taylor, C, Zhang, Y, Zhou, Z, Azizi, S.A, Jones, K, Kathayat, R, Snyder, S.A, Dickinson, B.C, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-10-07 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder608 inhibitor To Be Published
|
|
7SGW
| Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder630 inhibitor | Descriptor: | CHLORIDE ION, N-(naphthalen-1-yl)pyridine-3-carboxamide, Non-structural protein 3, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Lisnyak, V, Maki, S, Taylor, C, Zhang, Y, Zhou, Z, Azizi, S.A, Jones, K, Kathayat, R, Snyder, S.A, Dickinson, B.C, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-10-07 | Release date: | 2021-10-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder630 inhibitor To Be Published
|
|
7YP9
| |
7YPA
| |
7YPB
| |
8G59
| Cryo-EM structure of the TUG891 bound GPR120-Giq complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-08 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
|
|
6K3Z
| Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | Descriptor: | CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | Deposit date: | 2019-05-22 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
|
|
6K4P
| Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM) | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), PHOSPHATE ION, ... | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | Deposit date: | 2019-05-25 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
|
|
6K4U
| Crystal structure of xCas9 in complex with sgRNA and DNA (TGA PAM) | Descriptor: | CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ... | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | Deposit date: | 2019-05-27 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
|
|