8UO1
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNN
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNO
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNS
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNX
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNT
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNY
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UO2
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class R) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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8UNM
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B) | Descriptor: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Papasergi-Scott, M.M, Skiniotis, G. | Deposit date: | 2023-10-19 | Release date: | 2024-03-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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5I96
| Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor. | Descriptor: | 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, ACETATE ION, CALCIUM ION, ... | Authors: | Wei, W, Zhang, B, Jin, L, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. | Deposit date: | 2016-02-19 | Release date: | 2017-03-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
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5I95
| Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid | Descriptor: | 2-OXOGLUTARIC ACID, ACETATE ION, CALCIUM ION, ... | Authors: | Zhang, B, Jin, L, Wu, W, Jiang, F, DeLaBarre, B, Travins, J.A, Padyana, A.K. | Deposit date: | 2016-02-19 | Release date: | 2017-03-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discov, 7, 2017
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6KO1
| The crystal structue of PDE10A complexed with 2d | Descriptor: | 6-chloranyl-3-[2-(5-methyl-1-phenyl-benzimidazol-2-yl)ethyl]chromen-4-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Huang, Y.-Y, Yu, Y.F, Zhang, C, Guo, L, Wu, D, Luo, H.-B. | Deposit date: | 2019-08-07 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors. Acs Chem Neurosci, 11, 2020
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6L2T
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6L8O
| Crystal structure of the K. lactis Rad5 (Hg-derivative) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA repair protein RAD5, MERCURY (II) ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
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6L8N
| Crystal structure of the K. lactis Rad5 | Descriptor: | DNA repair protein RAD5, ZINC ION | Authors: | Shen, M, Xiang, S. | Deposit date: | 2019-11-06 | Release date: | 2020-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
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8J57
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with bedaquiline(BDQ) | Descriptor: | ATP synthase subunit a, ATP synthase subunit c, Bedaquiline | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-21 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J58
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in the apo-form | Descriptor: | ATP synthase subunit a, ATP synthase subunit c | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-21 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J0S
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with bedaquiline(BDQ) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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6IVA
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8JMT
| Structure of the adhesion GPCR ADGRL3 in the apo state | Descriptor: | Adhesion G protein-coupled receptor L3,Soluble cytochrome b562 | Authors: | Tao, Y, Guo, Q, He, B, Zhong, Y. | Deposit date: | 2023-06-05 | Release date: | 2023-09-06 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | A method for structure determination of GPCRs in various states. Nat.Chem.Biol., 20, 2024
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4G1N
| PKM2 in complex with an activator | Descriptor: | MAGNESIUM ION, N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]carbonyl}phenyl)quinoline-8-sulfonamide, OXALATE ION, ... | Authors: | Kung, C, Hixon, J, Dang, L, DeLaBarre, B, Qian, K.C. | Deposit date: | 2012-07-10 | Release date: | 2012-10-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. Chem.Biol., 19, 2012
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6M7P
| Human DNA polymerase eta extension complex with cdA at the -2 position | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*CP*(02I)P*CP*AP*CP*AP*CP*T)-3'), ... | Authors: | Gregory, M.T, Yang, W. | Deposit date: | 2018-08-20 | Release date: | 2018-09-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8JR0
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with TBAJ-587 | Descriptor: | (1~{S},2~{S})-1-(6-bromanyl-2-methoxy-quinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoranyl-3-methoxy-phenyl)butan-2-ol, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | Deposit date: | 2023-06-15 | Release date: | 2024-05-01 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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4FOE
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8KHF
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