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Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 Heavy chain, DH1047 light chain, ...
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-10-04
Release date:	2021-11-10
Last modified:	2022-02-09
Method:	ELECTRON MICROSCOPY (3.43 Å)
Cite:	A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. Sci Transl Med, 14, 2022

7LCN

Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1050.1
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1050.1 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-11
Release date:	2021-01-27
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.35 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7LAB

Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1052
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1052 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-06
Release date:	2021-03-10
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.97 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7LAA

Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1041
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1041 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-06
Release date:	2021-03-17
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7LD1

Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-12
Release date:	2021-01-27
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7THT

CryoEM structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1042 heavy chain, ...
Authors:	Manne, K, May, A, Acharya, P.
Deposit date:	2022-01-12
Release date:	2022-02-16
Last modified:	2023-04-12
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Structural diversity of the SARS-CoV-2 Omicron spike. Mol.Cell, 82, 2022

7KE8

SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2020-10-10
Release date:	2020-11-04
Last modified:	2022-02-02
Method:	ELECTRON MICROSCOPY (3.26 Å)
Cite:	D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. Cell Rep, 34, 2021

7KE9

SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2020-10-10
Release date:	2020-11-04
Last modified:	2021-03-31
Method:	ELECTRON MICROSCOPY (3.08 Å)
Cite:	D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction. Cell Rep, 34, 2021

7L09

Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound domain-swapped antibody 2G12 from masked 3D refinement
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ...
Authors:	Manne, K, Henderson, R, Acharya, P.
Deposit date:	2020-12-11
Release date:	2020-12-30
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7L6M

Cryo-EM structure of DH898.1 Fab-dimer from local refinement of the Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Descriptor:	DH898.1 Fab heavy chain, DH898.1 Fab light chain
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2020-12-23
Release date:	2021-02-10
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (4.7 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7L02

Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ...
Authors:	Manne, K, Henderson, R, Acharya, P.
Deposit date:	2020-12-10
Release date:	2020-12-30
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7L6O

Cryo-EM structure of HIV-1 Env CH848.3.D0949.10.17chim.6R.DS.SOSIP.664
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 - gp120, ...
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2020-12-23
Release date:	2021-04-14
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (3.9 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7LUA

Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 SOSIP gp120, ...
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2021-02-21
Release date:	2021-03-17
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (4.7 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7LU9

Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2021-02-21
Release date:	2021-03-24
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (5.6 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

6VTU

DH717.1 Fab monomer in complex with man9 glycan
Descriptor:	DH717.1 heavy chain, DH717.1 light chain, GLYCEROL, ...
Authors:	Fera, D, Bronkema, N.
Deposit date:	2020-02-13
Release date:	2020-12-30
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.61 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7LWJ

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.24 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWV

UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWI

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.07 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWQ

Mink Cluster 5-associated SARS-CoV-2 spike protein(S-GSAS-D614G-delFV) missing the S1 subunit and SD2 subdomain of one protomer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.44 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWM

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (2.83 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWL

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.84 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWK

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.92 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWW

Triple mutant (K417N-E484K-N501Y) SARS-CoV-2 spike protein in the 1-RBD-up conformation (S-GSAS-D614G-K417N-E484K-N501Y)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWO

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.85 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWP

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 2-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.01 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

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