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5IF0
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BU of 5if0 by Molmil
Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.44 A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, PHOSPHATE ION, ...
Authors:Sarkar, A, Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5ITB
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BU of 5itb by Molmil
Crystal structure of the anti-RSV F Fab 14N4
Descriptor: anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain
Authors:Mousa, J.J, Crowe, J.E.
Deposit date:2016-03-16
Release date:2016-10-26
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IES
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BU of 5ies by Molmil
Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.16 A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, ...
Authors:Sarkar, A, Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5IFA
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BU of 5ifa by Molmil
Crystal structure of unbound VRC01c-HuGL2 Fab from an HIV-1 naive donor at 1.82 A
Descriptor: GLYCEROL, PENTAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Sarkar, A, Wilson, I.A.
Deposit date:2016-02-25
Release date:2016-04-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.821 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
6PHF
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BU of 6phf by Molmil
Pfs25 in complex with the human transmission blocking antibody 2587
Descriptor: 25 kDa ookinete surface antigen, 2587 Antibody Fab, Heavy Chain, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6PHH
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BU of 6phh by Molmil
Unliganded human transmission blocking antibody 2544
Descriptor: 2544 Antibody Fab, Heavy Chain, Light Chain, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6PHC
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BU of 6phc by Molmil
Pfs25 in complex with the human transmission blocking antibody 2544
Descriptor: 25 kDa ookinete surface antigen, 2544 Antibody Fab, Heavy Chain, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6PHB
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BU of 6phb by Molmil
Pfs25 in complex with the human transmission blocking antibody 2530
Descriptor: 1,2-ETHANEDIOL, 25 kDa ookinete surface antigen, 2530 Antibody Fab, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6PHG
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BU of 6phg by Molmil
Predicted germline variant of human transmission blocking antibody 2544
Descriptor: GLYCEROL, Germline 2544 Antibody Fab, Heavy Chain, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6PHD
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BU of 6phd by Molmil
Pfs25 in complex with the human transmission blocking antibody 2586
Descriptor: 25 kDa ookinete surface antigen, 2586 Antibody Fab, Heavy Chain, ...
Authors:McLeod, B.R, Julien, J.P.
Deposit date:2019-06-25
Release date:2019-10-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Nat Commun, 10, 2019
6OC7
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BU of 6oc7 by Molmil
HMP42 Fab in complex with Protein G
Descriptor: Heavy chain of HMP42 Fab, Immunoglobulin G-binding protein G, Light chain for HMP42 Fab
Authors:Bernard, S.M, Wilson, I.A.
Deposit date:2019-03-22
Release date:2020-02-05
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
3QWO
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BU of 3qwo by Molmil
Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab
Descriptor: 1,2-ETHANEDIOL, SULFATE ION, motavizumab epitope scaffold, ...
Authors:McLellan, J.S, Kwong, P.D.
Deposit date:2011-02-28
Release date:2011-05-04
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.
J.Mol.Biol., 409, 2011
3RPT
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BU of 3rpt by Molmil
Crystal structure of the anti-HIV b12 scaffold protein
Descriptor: Endoglucanase E-2, SULFATE ION
Authors:Chen, L, Kwong, P.D.
Deposit date:2011-04-27
Release date:2011-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.303 Å)
Cite:Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
3RU8
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BU of 3ru8 by Molmil
Structure of an HIV epitope scaffold in complex with neutralizing antibody b12 Fab
Descriptor: Antibody b12, Heavy Chain, Light Chain, ...
Authors:Carrico, C.T.D, Strong, R.K.
Deposit date:2011-05-04
Release date:2011-11-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
3LEF
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BU of 3lef by Molmil
Crystal structure of HIV epitope-scaffold 4E10_S0_1Z6NA_001
Descriptor: 1,2-ETHANEDIOL, Uncharacterized protein 4E10_S0_1Z6NA_001 (T18)
Authors:Holmes, M.A.
Deposit date:2010-01-14
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF6
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BU of 3lf6 by Molmil
Crystal structure of HIV epitope-scaffold 4E10_1XIZA_S0_001_N
Descriptor: PHOSPHATE ION, Putative phosphotransferase system
Authors:Holmes, M.A.
Deposit date:2010-01-15
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LG7
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BU of 3lg7 by Molmil
Crystal structure of HIV epitope-scaffold 4E10_S0_1EZ3A_002_C
Descriptor: 4E10_S0_1EZ3A_002_C (T246), SULFATE ION
Authors:Holmes, M.A.
Deposit date:2010-01-19
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LHP
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BU of 3lhp by Molmil
Crystal structure of HIV epitope-scaffold 4E10_D0_1ISEA_004_N 4E10 Fv complex
Descriptor: 1,2-ETHANEDIOL, 4E10_D0_1ISEA_004_N (T93), Fv 4E10 heavy chain, ...
Authors:Holmes, M.A.
Deposit date:2010-01-22
Release date:2010-09-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LH2
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BU of 3lh2 by Molmil
Crystal structure of HIV epitope-scaffold 4E10_1VI7A_S0_002_N 4E10 Fv complex
Descriptor: 4E10_1VI7A_S0_002_N (T88), Fv 4E10 heavy chain, Fv 4E10 light chain
Authors:Holmes, M.A.
Deposit date:2010-01-21
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3LF9
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BU of 3lf9 by Molmil
Crystal structure of HIV epitope-scaffold 4E10_D0_1IS1A_001_C
Descriptor: 4E10_D0_1IS1A_001_C (T161)
Authors:Holmes, M.A.
Deposit date:2010-01-16
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
Structure, 18, 2010
3JWO
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BU of 3jwo by Molmil
Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB 48D Heavy CHAIN, FAB 48D LIGHT CHAIN, ...
Authors:Pancera, M, Majeed, S, Huang, C.C, Kwon, Y.D, Zhou, T, Robinson, J.E, Sodroski, J, Wyatt, R, Kwong, P.D.
Deposit date:2009-09-18
Release date:2009-12-29
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
7TI6
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BU of 7ti6 by Molmil
Crystal structure of the wild-type least mutated common ancestor (LMCA) of the HIV-targeting PCT64 antibody lineage
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, PCT64_LMCA Fab heavy chain, PCT64_LMCA light chain (wild type)
Authors:Omorodion, O, Wilson, I.A.
Deposit date:2022-01-12
Release date:2022-10-05
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Immunity, 55, 2022
8T4A
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BU of 8t4a by Molmil
MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, ...
Authors:Ozorowski, G, Torres, J.L, Ward, A.B.
Deposit date:2023-06-08
Release date:2024-05-08
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates.
Science, 384, 2024
8T49
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BU of 8t49 by Molmil
MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, ...
Authors:Ozorowski, G, Torres, J.L, Ward, A.B.
Deposit date:2023-06-08
Release date:2024-05-08
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates.
Science, 384, 2024
8SX3
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BU of 8sx3 by Molmil
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Descriptor: 10E8 Fab heavy chain, 10E8 light chain, 10E8-GT10.2 immunogen, ...
Authors:Huang, J, Ozorowski, G, Ward, A.B.
Deposit date:2023-05-19
Release date:2024-05-22
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Vaccination induces broadly neutralizing antibody precursors to HIV gp41.
Nat.Immunol., 25, 2024

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