7U9E
 
 | | Pfs230 D1 domain in complex with 230AL-26 | | Descriptor: | 230AL-26, Gametocyte surface protein P230, LMIV230-01 | | Authors: | Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-03-10 | | Release date: | 2023-02-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine.
Immunity, 56, 2023
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7UNB
 | | Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-117 and RUPA-47 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P45/48, RUPA-117 Fab heavy chain, ... | | Authors: | Hailemariam, S, McLeod, B, Julien, J.-P. | | Deposit date: | 2022-04-10 | | Release date: | 2022-08-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
Immunity, 55, 2022
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3VJR
 | | Crystal structure of Peptidyl-tRNA hydrolase from Escherichia coli in complex with the CCA-acceptor-T[PSI]C domain of tRNA | | Descriptor: | Peptidyl-tRNA hydrolase, tRNA CCA-acceptor | | Authors: | Ito, K, Murakami, R, Mochizuki, M, Qi, H, Shimizu, Y, Miura, K.I, Ueda, T, Uchiumi, T. | | Deposit date: | 2011-10-28 | | Release date: | 2012-09-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase.
Nucleic Acids Res., 40, 2012
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7ZXF
 | | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.72 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWM
 | | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWF
 | | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.132 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZXG
 | | Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWI
 | | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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8DFH
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8DFI
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8DFG
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8EZL
 | | Pfs25 in complex with transmission-reducing antibody AS01-50 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... | | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-11-01 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
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8EZM
 | | Pfs25 in complex with transmission-reducing antibody AS01-63 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, SULFATE ION, ... | | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | | Deposit date: | 2022-11-01 | | Release date: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25.
Npj Vaccines, 8, 2023
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8EZK
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6AZZ
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1190 | | Descriptor: | 1190 antibody, heavy chain, light chain, ... | | Authors: | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-13 | | Release date: | 2017-11-08 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0E
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260 | | Descriptor: | 1260 antibody, heavy chain, light chain, ... | | Authors: | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-14 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0G
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1245 | | Descriptor: | 1245 Antibody, Heavy Chain, Light Chain, ... | | Authors: | McLeod, B, Scally, S.W, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-14 | | Release date: | 2017-11-08 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0A
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1269 | | Descriptor: | 1269 antibody, heavy chain, light chain, ... | | Authors: | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-14 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B08
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1276 | | Descriptor: | 1276 antibody, heavy chain, light chain, ... | | Authors: | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-14 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0H
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1262 | | Descriptor: | 1,2-ETHANEDIOL, 1262 antibody, heavy chain, ... | | Authors: | McLeod, B, Scally, S.W, Bosch, A, King, C.R, Julien, J.P. | | Deposit date: | 2017-09-14 | | Release date: | 2017-11-15 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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3SIC
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6PHF
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6PHH
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6PHC
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6PHB
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