3TUG
 
 | | Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase | | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION | | Authors: | Dong, A, Dobrovetsky, E, Xue, S, Butler, C, Wernimont, A, Walker, J.R, Tempel, W, Dhe-Paganon, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-09-16 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
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7SZC
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7SZD
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7SZB
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7SZA
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7TUO
 | | Crystal structure analysis of human USP28 complex with a compound | | Descriptor: | 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28 | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2022-02-03 | | Release date: | 2023-02-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Crystal Structure Analysis of human USP28 complex with a compound
To Be Published
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7TUN
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7U5W
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7U5X
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3V6C
 | | Crystal Structure of USP2 in complex with mutated ubiquitin | | Descriptor: | CHLORIDE ION, GLYCEROL, Ubiquitin, ... | | Authors: | Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-12-19 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure of USP2 in complex with mutated ubiquitin
To be Published
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3OLN
 | | Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF2 | | Descriptor: | E3 ubiquitin-protein ligase UHRF2 | | Authors: | Walker, J.R, Xue, S, Avvakumov, G.V, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-08-26 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Set and Ring Associated (SRA) domain of human ubiquitin-like containing PHD and RING finger domains 2 (UHRF2)
To be Published
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3V6E
 | | Crystal Structure of USP2 and a mutant form of Ubiquitin | | Descriptor: | CHLORIDE ION, GLYCEROL, Ubiquitin, ... | | Authors: | Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-12-19 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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3JYU
 | | Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4) | | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Ubiquitin carboxyl-terminal hydrolase | | Authors: | Bacik, J.P, Avvakumov, G, Walker, J.R, Xue, S, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-09-22 | | Release date: | 2009-10-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)
To be Published
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5TVT
 | | Structure of Maternal Embryonic Leucine Zipper Kinase | | Descriptor: | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one, Maternal embryonic leucine zipper kinase | | Authors: | Seo, H.-Y, Huang, H, Gray, N.S, Dhe-Paganon, S. | | Deposit date: | 2016-11-10 | | Release date: | 2017-11-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Structure of Maternal Embryonic Leucine Zipper Kinase
To Be Published
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3MTN
 | | Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor | | Descriptor: | CHLORIDE ION, GLYCEROL, UBIQUITIN VARIANT UBV.21.4, ... | | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-04-30 | | Release date: | 2010-06-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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6U9Q
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6UCH
 | | SMARCB1 nucleosome-interacting C-terminal alpha helix | | Descriptor: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | | Authors: | Valencia, A.M, Sun, Z.Y.J, Seo, H.S, Vangos, H.S, Yeoh, Z.C, Mashtalir, N, Dhe-Paganon, S, Kadoch, C. | | Deposit date: | 2019-09-16 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.
Cell, 179, 2019
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6UX9
 | | Crystal Structure Analysis of PIP4K2A | | Descriptor: | N-[4-(5-{(Z)-[(2E)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}pyridin-3-yl)phenyl]methanesulfonamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-11-07 | | Release date: | 2020-12-09 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
J.Med.Chem., 63, 2020
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6V4G
 | | Crystal Structure Analysis of Zebra fish MDMX | | Descriptor: | Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2) | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-11-27 | | Release date: | 2020-04-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
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6V4H
 | | Crystal Structure Analysis of Zebra Fish MDMX | | Descriptor: | Protein Mdm4, Stapled Peptide LSQETF(0EH)DLWKLL(MK8)EN(NH2) | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-11-27 | | Release date: | 2020-04-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
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6V4E
 | | Crystal Structure Analysis of Zebra Fish MDM | | Descriptor: | Protein Mdm4, Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2) | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-11-27 | | Release date: | 2020-04-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
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6V4F
 | | Crystal Structure Analysis of Zebra Fish MDMX | | Descriptor: | Protein Mdm4, SULFATE ION, Stapled Peptide LSQETF(0EH)DLWKLE(MK8)EN(NH2) | | Authors: | Seo, H.-S, Dhe-Paganon, S. | | Deposit date: | 2019-11-27 | | Release date: | 2020-04-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Identification of a Structural Determinant for Selective Targeting of HDMX.
Structure, 28, 2020
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3S8I
 | | The retroviral-like protease (RVP) domain of human DDI1 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | | Authors: | Walker, J.R, Asinas, A, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-05-28 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Retropepsin-Like Domain of Human DDI1
To be Published
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3U12
 | | The pleckstrin homology (PH) domain of USP37 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | | Authors: | Dong, A, Nair, U.B, Wernimont, A, Walker, J.R, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-09-29 | | Release date: | 2011-11-09 | | Last modified: | 2012-05-02 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | The pleckstrin homology (PH) domain of USP37
To be Published
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3NRU
 | | Ligand binding domain of EPHA7 | | Descriptor: | CHLORIDE ION, Ephrin receptor, SULFATE ION | | Authors: | Walker, J.R, Yermekbayeva, L, Seitova, A, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S. | | Deposit date: | 2010-06-30 | | Release date: | 2010-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Ephrin A7 ligand binding domain
To be Published
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