6ZGD
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![BU of 6zgd by Molmil](/molmil-images/mine/6zgd) | GLIC pentameric ligand-gated ion channel, pH 7 | Descriptor: | Proton-gated ion channel | Authors: | Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E. | Deposit date: | 2020-06-18 | Release date: | 2021-05-26 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Sci Alliance, 4, 2021
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6ZGJ
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![BU of 6zgj by Molmil](/molmil-images/mine/6zgj) | GLIC pentameric ligand-gated ion channel, pH 5 | Descriptor: | Proton-gated ion channel | Authors: | Rovsnik, U, Zhuang, Y, Forsberg, B.O, Carroni, M, Yvonnesdotter, L, Howard, R.J, Lindahl, E. | Deposit date: | 2020-06-18 | Release date: | 2021-05-26 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Sci Alliance, 4, 2021
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6TQL
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![BU of 6tql by Molmil](/molmil-images/mine/6tql) | Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Stsiapanava, A, Xu, C, Carroni, M, Wu, B, Jovine, L. | Deposit date: | 2019-12-16 | Release date: | 2020-11-04 | Last modified: | 2021-03-03 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. Embo J., 39, 2020
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6XZ6
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![BU of 6xz6 by Molmil](/molmil-images/mine/6xz6) | |
7PGT
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![BU of 7pgt by Molmil](/molmil-images/mine/7pgt) | The structure of human neurofibromin isoform 2 in opened conformation. | Descriptor: | Neurofibromin, ZINC ION | Authors: | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | Deposit date: | 2021-08-15 | Release date: | 2021-11-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599, 2021
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7PGS
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![BU of 7pgs by Molmil](/molmil-images/mine/7pgs) | Consensus structure of human Neurofibromin isoform 2 | Descriptor: | Neurofibromin, ZINC ION | Authors: | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | Deposit date: | 2021-08-15 | Release date: | 2021-11-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599, 2021
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7PGR
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![BU of 7pgr by Molmil](/molmil-images/mine/7pgr) | The structure of human neurofibromin isoform 2 in closed conformation | Descriptor: | Neurofibromin, ZINC ION | Authors: | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | Deposit date: | 2021-08-15 | Release date: | 2021-11-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599, 2021
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7PGU
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![BU of 7pgu by Molmil](/molmil-images/mine/7pgu) | Autoinhibited structure of human neurofibromin isoform 2 stabilized by Zinc. | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Neurofibromin, ZINC ION | Authors: | Naschberger, A, Baradaran, R, Carroni, M, Rupp, B. | Deposit date: | 2021-08-15 | Release date: | 2021-11-17 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structure of neurofibromin isoform 2 reveals different functional states. Nature, 599, 2021
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6FU8
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![BU of 6fu8 by Molmil](/molmil-images/mine/6fu8) | |
6FB3
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![BU of 6fb3 by Molmil](/molmil-images/mine/6fb3) | Teneurin 2 Partial Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Teneurin-2, ... | Authors: | Jackson, V.A, Carrasquero, M, Lowe, E.D, Seiradake, E. | Deposit date: | 2017-12-18 | Release date: | 2018-03-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nat Commun, 9, 2018
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6HMS
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![BU of 6hms by Molmil](/molmil-images/mine/6hms) | Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA | Descriptor: | DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ... | Authors: | Raia, P, Carroni, M, Sauguet, L. | Deposit date: | 2018-09-12 | Release date: | 2019-01-30 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases. PLoS Biol., 17, 2019
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3TTI
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![BU of 3tti by Molmil](/molmil-images/mine/3tti) | Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 10, trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | Authors: | Plantevin-Krenitsky, V, Nadolny, L, Delgado, M, Ayala, L, Clareen, S, Hilgraf, R, Albers, R, Hegde, S, D'Sidocky, N, Sapienza, J, Wright, J, McCarrick, M, Bahmanyar, S, Chamberlain, P, Delker, S.L, Muir, J, Giegel, D, Xu, L, Celeridad, M, Lachowitzer, J, Bennett, B, Moghaddam, M, Khatsenko, O, Katz, J, Fan, R, Bai, A, Tang, Y, Shirley, M.A, Benish, B, Bodine, T, Blease, K, Raymon, H, Cathers, B.E, Satoh, Y. | Deposit date: | 2011-09-14 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg.Med.Chem.Lett., 22, 2012
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6T7Y
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![BU of 6t7y by Molmil](/molmil-images/mine/6t7y) | Structure of PCNA bound to cPIP motif of DP2 from P. abyssi | Descriptor: | DNA polymerase sliding clamp, cPIP motif from the DP2 large subunit of PolD | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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6T7X
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![BU of 6t7x by Molmil](/molmil-images/mine/6t7x) | Crystal structure of PCNA from P. abyssi | Descriptor: | DNA polymerase sliding clamp | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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6T8H
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![BU of 6t8h by Molmil](/molmil-images/mine/6t8h) | Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi | Descriptor: | DNA polymerase II small subunit, DNA polymerase sliding clamp, DNA primer, ... | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Pehau-Arnaudet, G, England, P, Lindhal, E, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-24 | Release date: | 2020-03-04 | Last modified: | 2020-04-08 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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2JWG
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![BU of 2jwg by Molmil](/molmil-images/mine/2jwg) | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein | Descriptor: | Variant surface glycoprotein ILTAT 1.24 | Authors: | Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M. | Deposit date: | 2007-10-12 | Release date: | 2007-11-13 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein J.Biol.Chem., 283, 2008
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3OLS
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![BU of 3ols by Molmil](/molmil-images/mine/3ols) | Crystal structure of estrogen receptor beta ligand binding domain | Descriptor: | ESTRADIOL, Estrogen receptor beta, Nuclear receptor coactivator 1 | Authors: | Moecklinghoff, S, Rose, R, Carraz, M, Visser, A, Ottmann, C, Brunsveld, L. | Deposit date: | 2010-08-26 | Release date: | 2010-11-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain. Chembiochem, 11, 2010
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1ZUJ
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![BU of 1zuj by Molmil](/molmil-images/mine/1zuj) | The crystal structure of the Lactococcus lactis MG1363 DpsA protein | Descriptor: | hypothetical protein Llacc01001955 | Authors: | Stillman, T.J, Upadhyay, M, Norte, V.A, Sedelnikova, S.E, Carradus, M, Tzokov, S, Bullough, P.A, Shearman, C.A, Gasson, M.J, Williams, C.H, Artymiuk, P.J, Green, J. | Deposit date: | 2005-05-31 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structures of Lactococcus lactis MG1363 Dps proteins reveal the presence of an N-terminal helix that is required for DNA binding. Mol.Microbiol., 57, 2005
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1ZS3
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![BU of 1zs3 by Molmil](/molmil-images/mine/1zs3) | The crystal structure of the Lactococcus lactis MG1363 DpsB protein | Descriptor: | Lactococcus lactis MG1363 DpsA | Authors: | Stillman, T.J, Upadhyay, M, Norte, V.A, Sedelnikova, S.E, Carradus, M, Tzokov, S, Bullough, P.A, Shearman, C.A, Gasson, M.J, Williams, C.H, Artymiuk, P.J, Green, J. | Deposit date: | 2005-05-23 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structures of Lactococcus lactis MG1363 Dps proteins reveal the presence of an N-terminal helix that is required for DNA binding. Mol.Microbiol., 57, 2005
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3QIM
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![BU of 3qim by Molmil](/molmil-images/mine/3qim) | Histidine 416 of the periplamsic binding protein NikA is essential for nickel uptake in Escherichia coli | Descriptor: | ACETATE ION, GLYCEROL, Nickel-binding periplasmic protein, ... | Authors: | Cavazza, C, Martin, L, Laffly, E, Lebrette, H, Cherrier, M.V, Zeppieri, L, Richaud, P, Carriere, M, Fontecilla-Camps, J.C. | Deposit date: | 2011-01-27 | Release date: | 2011-03-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Histidine 416 of the periplasmic binding protein NikA is essential for nickel uptake in Escherichia coli Febs Lett., 585, 2011
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2JWH
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![BU of 2jwh by Molmil](/molmil-images/mine/2jwh) | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein | Descriptor: | Variant surface glycoprotein ILTAT 1.24 | Authors: | Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M. | Deposit date: | 2007-10-12 | Release date: | 2007-11-13 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein J.Biol.Chem., 283, 2008
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6SOY
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![BU of 6soy by Molmil](/molmil-images/mine/6soy) | Trypanosoma brucei transferrin receptor in complex with human transferrin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ... | Authors: | Trevor, C, Carrington, M, Higgins, M.K. | Deposit date: | 2019-08-30 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nat Microbiol, 4, 2019
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6SOZ
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![BU of 6soz by Molmil](/molmil-images/mine/6soz) | Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, ... | Authors: | Trevor, C, Carrington, M, Higgins, M.K. | Deposit date: | 2019-08-30 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nat Microbiol, 4, 2019
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5OFO
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![BU of 5ofo by Molmil](/molmil-images/mine/5ofo) | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state, bound to the model substrate casein | Descriptor: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | Deposit date: | 2017-07-11 | Release date: | 2017-08-16 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Sci Adv, 3, 2017
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5OG1
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![BU of 5og1 by Molmil](/molmil-images/mine/5og1) | Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state | Descriptor: | Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Deville, C, Carroni, M, Franke, K.B, Topf, M, Bukau, B, Mogk, A, Saibil, H.R. | Deposit date: | 2017-07-11 | Release date: | 2017-08-16 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase. Sci Adv, 3, 2017
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