3BUE
| Crystal structure of the C-terminal domain hexamer of ArgR from Mycobacterium tuberculosis | Descriptor: | Arginine repressor ArgR | Authors: | Cherney, L.T, Cherney, M.M, Garen, C.R, Lu, G.J, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2008-01-02 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 64, 2008
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1NFP
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4H88
| Structure of POM1 FAB fragment complexed with mouse PrPc Fragment 120-230 | Descriptor: | Major prion protein, POM1 FAB CHAIN H, POM1 FAB CHAIN L, ... | Authors: | Baral, P.K, Wieland, B, Swayampakula, M, James, M.N. | Deposit date: | 2012-09-21 | Release date: | 2013-07-31 | Last modified: | 2013-09-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501, 2013
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1S2B
| Structure of SCP-B the first member of the Eqolisin family of Peptidases to have its structure determined | Descriptor: | Scytalidopepsin B | Authors: | Fujinaga, M, Cherney, M.M, Oyama, H, Oda, K, James, M.N. | Deposit date: | 2004-01-08 | Release date: | 2004-04-27 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum Proc.Natl.Acad.Sci.USA, 101, 2004
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1S2K
| Structure of SCP-B a member of the Eqolisin family of Peptidases in a complex with a Tripeptide Ala-Ile-His | Descriptor: | Ala-Ile-His tripeptide, Scytalidopepsin B, TYROSINE | Authors: | Fujinaga, M, Cherney, M.M, Oyama, H, Oda, K, James, M.N. | Deposit date: | 2004-01-08 | Release date: | 2004-04-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum Proc.Natl.Acad.Sci.USA, 101, 2004
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3IT4
| The Crystal Structure of Ornithine Acetyltransferase from Mycobacterium tuberculosis (Rv1653) at 1.7 A | Descriptor: | ACETATE ION, Arginine biosynthesis bifunctional protein argJ alpha chain, Arginine biosynthesis bifunctional protein argJ beta chain, ... | Authors: | Sankaranarayanan, R, Cherney, M.M, Garen, C, Garen, G, Yuan, M, James, M.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2009-08-27 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor. J.Mol.Biol., 397, 2010
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3IT6
| The Crystal Structure of Ornithine Acetyltransferase complexed with Ornithine from Mycobacterium tuberculosis (Rv1653) at 2.4 A | Descriptor: | Arginine biosynthesis bifunctional protein argJ alpha chain, Arginine biosynthesis bifunctional protein argJ beta chain, L-ornithine | Authors: | Sankaranarayanan, R, Cherney, M.M, Garen, C, Garen, G, Yuan, M, James, M.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2009-08-27 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor. J.Mol.Biol., 397, 2010
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3KPK
| Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans, C160A mutant | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, HYDROSULFURIC ACID, ... | Authors: | Cherney, M.M, Zhang, Y, Solomonson, M, Weiner, J.H, James, M.N.G. | Deposit date: | 2009-11-16 | Release date: | 2010-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification. J.Mol.Biol., 398, 2010
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4J8R
| Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment | Descriptor: | Heavy chain of POM2 Fab, Light chain of POM2 Fab, Major prion protein | Authors: | Swayampakula, M, Baral, P.K, Kav, N.N.V, Aguzzi, A, James, M.N.G. | Deposit date: | 2013-02-14 | Release date: | 2013-05-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | The crystal structure of an octapeptide repeat of the Prion protein in complex with a Fab fragment of the POM2 antibody. Protein Sci., 22, 2013
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3LPN
| Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with an ATP analog (AMPCPP). | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Ribose-phosphate pyrophosphokinase, SULFATE ION | Authors: | Cherney, M.M, Cherney, L.T, Garen, C.R, James, M.N.G. | Deposit date: | 2010-02-05 | Release date: | 2011-02-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs. J.Mol.Biol., 413, 2011
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3LAP
| The Structure of the Intermediate Complex of the Arginine Repressor from Mycobacterium tuberculosis Bound to its DNA Operator and L-canavanine. | Descriptor: | 5'-D(*TP*TP*GP*CP*AP*TP*AP*AP*CP*GP*AP*TP*GP*CP*AP*A)-3', 5'-D(*TP*TP*GP*CP*AP*TP*CP*GP*TP*TP*AP*TP*GP*CP*AP*A)-3', Arginine repressor, ... | Authors: | Cherney, L.T, Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2010-01-06 | Release date: | 2010-05-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression. J.Mol.Biol., 399, 2010
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3LAJ
| The Structure of the Intermediate Complex of the Arginine Repressor from Mycobacterium tuberculosis Bound to its DNA Operator and L-arginine. | Descriptor: | 5'-D(*TP*TP*GP*CP*AP*TP*AP*AP*CP*GP*AP*TP*GP*CP*AP*A)-3', 5'-D(*TP*TP*GP*CP*AP*TP*CP*GP*TP*TP*AP*TP*GP*CP*AP*A)-3', ARGININE, ... | Authors: | Cherney, L.T, Cherney, M.M, Garen, C.R, James, M.N.G, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2010-01-06 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.306 Å) | Cite: | crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression. J.Mol.Biol., 399, 2010
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3LRT
| Crystal structure of the phosphoribosyl pyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Ribose-phosphate pyrophosphokinase, SULFATE ION | Authors: | Cherney, M.M, Cherney, L.T, Garen, C.R, James, M.N.G. | Deposit date: | 2010-02-11 | Release date: | 2011-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.534 Å) | Cite: | The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs. J.Mol.Biol., 413, 2011
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4KGJ
| Crystal structure of human alpha-L-iduronidase complex with 5-fluoro-alpha-L-idopyranosyluronic acid fluoride | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-fluoro-alpha-L-idopyranosyluronic acid fluoride, ... | Authors: | Bie, H, Yin, J, He, X, Kermode, A.R, Goddard-Borger, E.D, Withers, S.G, James, M.N.G. | Deposit date: | 2013-04-29 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9, 2013
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4KH2
| Crystal structure of human alpha-L-iduronidase complex with 2-deoxy-2-fluoro-alpha-L-idopyranosyluronic acid fluoride | Descriptor: | 2,6-anhydro-5-deoxy-5-fluoro-L-idonic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bie, H, Yin, J, He, X, Kermode, A.R, Goddard-Borger, E.D, Withers, S.G, James, M.N.G. | Deposit date: | 2013-04-29 | Release date: | 2013-09-18 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9, 2013
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1JAK
| Streptomyces plicatus beta-N-acetylhexosaminidase in Complex with (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (IFG) | Descriptor: | (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | Authors: | Mark, B.L, Vocadlo, D.J, Zhao, D, Knapp, S, Withers, S.G, James, M.N. | Deposit date: | 2001-05-30 | Release date: | 2001-11-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. J.Biol.Chem., 276, 2001
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1BXO
| ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE | Descriptor: | GLYCEROL, METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUTYL]HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL)PHENYLPROPANOATE, PROTEIN (PENICILLOPEPSIN), ... | Authors: | Khan, A.R, Parrish, J.C, Fraser, M.E, Smith, W.W, Bartlett, P.A, James, M.N.G. | Deposit date: | 1998-10-07 | Release date: | 1998-10-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes. Biochemistry, 37, 1998
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1BXQ
| ACID PROTEINASE (PENICILLOPEPSIN) COMPLEX WITH PHOSPHONATE INHIBITOR. | Descriptor: | 2-[(1R)-1-(N-(3-METHYLBUTANOYL)-L-VALYL-L-ASPARAGINYL)-AMINO)-3-METHYLBUTYL]HYDROXYPHOSPHINYLOXY]-3-PHENYLPROPANOIC ACID METHYLESTER, ACETATE ION, GLYCEROL, ... | Authors: | Parrish, J.C, Khan, A.R, Fraser, M.E, Smith, W.W, Bartlett, P.A, James, M.N.G. | Deposit date: | 1998-10-07 | Release date: | 1998-10-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes. Biochemistry, 37, 1998
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2H6M
| An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | Descriptor: | N-ACETYL-LEUCYL-ALANYL-ALANYL-(N,N-DIMETHYL)-GLUTAMINE-(1,4-DIOXO-3,4-DIHYDRO-1H-PHTHALAZIN-2-YL)METHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Picornain 3C | Authors: | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | Deposit date: | 2006-05-31 | Release date: | 2006-08-08 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J.Mol.Biol., 361, 2006
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9LYZ
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4YX2
| Crystal structure of Bovine prion protein complexed with POM1 FAB | Descriptor: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2015-03-22 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXL
| Crystal structure of Syrian hamster prion protein complexed with POM1 FAB | Descriptor: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2015-03-23 | Release date: | 2015-09-23 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXK
| Crystal structure of Elk prion protein complexed with POM1 FAB | Descriptor: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2015-03-23 | Release date: | 2015-09-23 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXH
| Crystal structure of Deer prion protein complexed with POM1 FAB | Descriptor: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | Authors: | Baral, P.K, Swayampakula, M, James, M.N.G. | Deposit date: | 2015-03-23 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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1CT2
| CRYSTAL STRUCTURE OF THE OMTKY3 P1 VARIANT OMTKY3-THR18I IN COMPLEX WITH SGPB | Descriptor: | OVOMUCOID INHIBITOR, PROTEINASE B | Authors: | Bateman, K.S, Anderson, S, Lu, W, Qasim, M.A, Laskowski Jr, M, James, M.N. | Deposit date: | 1999-08-18 | Release date: | 2000-01-12 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB. Protein Sci., 9, 2000
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