8IP0
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![BU of 8ip0 by Molmil](/molmil-images/mine/8ip0) | Cryo-EM structure of type I-B Cascade bound to a PAM-containing dsDNA target at 3.6 angstrom resolution | Descriptor: | CRISPR associated protein Cas11b, DNA (41-MER), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | Authors: | Xiao, Y, Lu, M, Yu, C, Zhang, Y. | Deposit date: | 2023-03-13 | Release date: | 2024-03-20 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure and genome editing of type I-B CRISPR-Cas. Nat Commun, 15, 2024
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7WNV
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![BU of 7wnv by Molmil](/molmil-images/mine/7wnv) | Crystal structure of mutant estrogen receptor alpha Y537S in complex with CO9 | Descriptor: | (~{Z})-4-[2-[4-[[2-(4-hydroxyphenyl)-6-oxidanyl-1-benzothiophen-3-yl]oxy]phenoxy]ethylamino]-~{N},~{N}-dimethyl-but-2-enamide, Estrogen receptor | Authors: | Xiao, Y, Lv, Y. | Deposit date: | 2022-01-19 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles. Bioorg.Chem., 141, 2023
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8IVY
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![BU of 8ivy by Molmil](/molmil-images/mine/8ivy) | Beta-Glucosidase BglA mutant E166Q in complex with glucose | Descriptor: | Beta-glucosidase, GLYCEROL, beta-D-glucopyranose | Authors: | Dong, S, Xiao, Y, Feng, Y. | Deposit date: | 2023-03-29 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Key roles of beta-glucosidase BglA for the catabolism of both laminaribiose and cellobiose in the lignocellulolytic bacterium Clostridium thermocellum. Int.J.Biol.Macromol., 250, 2023
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5KLV
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![BU of 5klv by Molmil](/molmil-images/mine/5klv) | Structure of bos taurus cytochrome bc1 with fenamidone inhibited | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | Authors: | Xia, D, Esser, L, Zhou, F, Zhou, Y, Xiao, Y, Tang, W.K, Yu, C.A, Qin, Z. | Deposit date: | 2016-06-25 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III. J.Biol.Chem., 291, 2016
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8JY0
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![BU of 8jy0 by Molmil](/molmil-images/mine/8jy0) | Crystal structure of RhoBAST complexed with TMR-DN | Descriptor: | 2,4-dinitroaniline, 5-aminocarbonyl-2-[3-(dimethylamino)-6-dimethylazaniumylidene-xanthen-9-yl]benzoate, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Zhang, Y, Xiao, Y, Xu, Z, Fang, X. | Deposit date: | 2023-07-02 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nat Commun, 15, 2024
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4YJE
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![BU of 4yje by Molmil](/molmil-images/mine/4yje) | Crystal structure of APC-ARM in complexed with Amer1-A1 | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-03 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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4YJL
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![BU of 4yjl by Molmil](/molmil-images/mine/4yjl) | Crystal structure of APC-ARM in complexed with Amer1-A2 | Descriptor: | 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-03 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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4YK6
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![BU of 4yk6 by Molmil](/molmil-images/mine/4yk6) | Crystal structure of APC-ARM in complexed with Amer1-A4 | Descriptor: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | Authors: | Zhang, Z, Xiao, Y, Wu, G. | Deposit date: | 2015-03-04 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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5HQA
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![BU of 5hqa by Molmil](/molmil-images/mine/5hqa) | A Glycoside Hydrolase Family 97 enzyme in complex with Acarbose from Pseudoalteromonas sp. strain K8 | Descriptor: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, Alpha-glucosidase, CALCIUM ION, ... | Authors: | Li, J, He, C, Xiao, Y. | Deposit date: | 2016-01-21 | Release date: | 2017-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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5HQB
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![BU of 5hqb by Molmil](/molmil-images/mine/5hqb) | A Glycoside Hydrolase Family 97 enzyme (E480Q) in complex with Panose from Pseudoalteromonas sp. strain K8 | Descriptor: | Alpha-glucosidase, CALCIUM ION, CHLORIDE ION, ... | Authors: | Li, J, He, C, Xiao, Y. | Deposit date: | 2016-01-21 | Release date: | 2017-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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5HQ4
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![BU of 5hq4 by Molmil](/molmil-images/mine/5hq4) | A Glycoside Hydrolase Family 97 enzyme from Pseudoalteromonas sp. strain K8 | Descriptor: | Alpha-glucosidase, CALCIUM ION, CHLORIDE ION, ... | Authors: | Li, J, He, C, Xiao, Y. | Deposit date: | 2016-01-21 | Release date: | 2017-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.926 Å) | Cite: | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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5HQC
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![BU of 5hqc by Molmil](/molmil-images/mine/5hqc) | A Glycoside Hydrolase Family 97 enzyme R171K variant from Pseudoalteromonas sp. strain K8 | Descriptor: | CALCIUM ION, CHLORIDE ION, FORMIC ACID, ... | Authors: | Li, J, He, C, Xiao, Y. | Deposit date: | 2016-01-21 | Release date: | 2017-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation. J. Struct. Biol., 196, 2016
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4ZM6
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![BU of 4zm6 by Molmil](/molmil-images/mine/4zm6) | A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain GH3 beta-N-acetylglucosaminidase | Descriptor: | ACETYL COENZYME *A, N-acetyl-beta-D glucosaminidase, SULFATE ION | Authors: | Qin, Z, Xiao, Y, Yang, X, Jiang, Z, Yang, S, Mesters, J.R. | Deposit date: | 2015-05-02 | Release date: | 2015-12-09 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 beta-N-acetylglucosaminidase Sci Rep, 5, 2015
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3VCA
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![BU of 3vca by Molmil](/molmil-images/mine/3vca) | Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman and UV-visible Spectroscopic Analysis of a Rieske-type Demethylase | Descriptor: | FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, ... | Authors: | Daughtry, K.D, Xiao, Y, Stoner-Ma, D, Cho, E, Orville, A.M, Liu, P, Allen, K.N. | Deposit date: | 2012-01-03 | Release date: | 2012-02-08 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman, and UV-Visible Spectroscopic Analysis of a Rieske-Type Demethylase. J.Am.Chem.Soc., 134, 2012
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3VCP
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![BU of 3vcp by Molmil](/molmil-images/mine/3vcp) | The 2.2 Angstrom structure of Stc2 with proline bound in the active site | Descriptor: | FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, PROLINE, ... | Authors: | Daughtry, K.D, Xiao, Y, Stoner-Ma, D, Cho, E, Orville, A.M, Liu, P, Allen, K.N. | Deposit date: | 2012-01-04 | Release date: | 2012-02-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman, and UV-Visible Spectroscopic Analysis of a Rieske-Type Demethylase. J.Am.Chem.Soc., 134, 2012
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5H9E
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![BU of 5h9e by Molmil](/molmil-images/mine/5h9e) | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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5H9F
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![BU of 5h9f by Molmil](/molmil-images/mine/5h9f) | Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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4F7K
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![BU of 4f7k by Molmil](/molmil-images/mine/4f7k) | |
6LUM
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![BU of 6lum by Molmil](/molmil-images/mine/6lum) | Structure of Mycobacterium smegmatis succinate dehydrogenase 2 | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ... | Authors: | Gao, Y, Gong, H, Zhou, X, Xiao, Y, Wang, W, Ji, W, Wang, Q, Rao, Z. | Deposit date: | 2020-01-29 | Release date: | 2020-05-27 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF. Nat Commun, 11, 2020
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2YNB
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![BU of 2ynb by Molmil](/molmil-images/mine/2ynb) | |
2YNA
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![BU of 2yna by Molmil](/molmil-images/mine/2yna) | |
3O5Z
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![BU of 3o5z by Molmil](/molmil-images/mine/3o5z) | Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Phosphatidylinositol 3-kinase regulatory subunit beta | Authors: | Chen, S, Xiao, Y, Ponnusamy, R, Tan, J, Lei, J, Hilgenfeld, R. | Deposit date: | 2010-07-28 | Release date: | 2011-08-10 | Last modified: | 2014-09-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit Acta Crystallogr.,Sect.F, 67, 2011
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1U9S
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![BU of 1u9s by Molmil](/molmil-images/mine/1u9s) | Crystal structure of the specificity domain of Ribonuclease P of the A-type | Descriptor: | BARIUM ION, RIBONUCLEASE P | Authors: | Krasilnikov, A.S, Xiao, Y, Pan, T, Mondragon, A. | Deposit date: | 2004-08-10 | Release date: | 2004-10-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Basis for structural diversity in homologous RNAs. Science, 306, 2004
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3SJM
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![BU of 3sjm by Molmil](/molmil-images/mine/3sjm) | Crystal Structure Analysis of TRF2-Dbd-DNA complex | Descriptor: | DNA (5'-D(*CP*TP*CP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*GP*A)-3'), Telomeric repeat-binding factor 2 | Authors: | Nair, S.K, Sliverman, S.K, Chen, J.H, Xiao, Y. | Deposit date: | 2011-06-21 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Crystal Structure Analysis of TRF2-Dbd-DNA complex To be Published
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6N13
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![BU of 6n13 by Molmil](/molmil-images/mine/6n13) | UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin | Descriptor: | E3 ubiquitin-protein ligase parkin, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ... | Authors: | Condos, T.E.C, Dunkerley, K.M, Freeman, E.A, Barber, K.R, Aguirre, J.D, Chaugule, V.K, Xiao, Y, Konermann, L, Walden, H, Shaw, G.S. | Deposit date: | 2018-11-08 | Release date: | 2018-11-28 | Last modified: | 2020-01-08 | Method: | SOLUTION NMR | Cite: | Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation. EMBO J., 37, 2018
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