5KN8
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![BU of 5kn8 by Molmil](/molmil-images/mine/5kn8) | MutY N-terminal domain in complex with undamaged DNA | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
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4YPR
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![BU of 4ypr by Molmil](/molmil-images/mine/4ypr) | Crystal Structure of D144N MutY bound to its anti-substrate | Descriptor: | A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ... | Authors: | Wang, L, Lee, S, Verdine, G.L. | Deposit date: | 2015-03-13 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J.Biol.Chem., 290, 2015
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1MLW
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![BU of 1mlw by Molmil](/molmil-images/mine/1mlw) | Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III) | Descriptor: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, Tryptophan 5-monooxygenase | Authors: | Wang, L, Erlandsen, H, Haavik, J, Knappskog, P.M, Stevens, R.C. | Deposit date: | 2002-08-31 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry, 41, 2002
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4GAW
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![BU of 4gaw by Molmil](/molmil-images/mine/4gaw) | Crystal structure of active human granzyme H | Descriptor: | CHLORIDE ION, Granzyme H, SULFATE ION | Authors: | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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4GA7
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![BU of 4ga7 by Molmil](/molmil-images/mine/4ga7) | Crystal structure of human serpinB1 mutant | Descriptor: | Leukocyte elastase inhibitor | Authors: | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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6EGA
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![BU of 6ega by Molmil](/molmil-images/mine/6ega) | IRAK4 in complex with a type II inhibitor | Descriptor: | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | Authors: | Wang, L, Wu, H. | Deposit date: | 2018-08-19 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.512 Å) | Cite: | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6FXD
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![BU of 6fxd by Molmil](/molmil-images/mine/6fxd) | Crystal structure of MupZ from Pseudomonas fluorescens | Descriptor: | MupZ | Authors: | Wang, L, Parnell, A, Williams, C, Bakar, N.A, van der Kamp, M.W, Simpson, T.J, Race, P.R, Crump, M.P, Willis, C.L. | Deposit date: | 2018-03-08 | Release date: | 2019-03-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis Nat Catal, 2018
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6EG9
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![BU of 6eg9 by Molmil](/molmil-images/mine/6eg9) | IRAK4 in complex with Ponatinib | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | Authors: | Wang, L, Wu, H. | Deposit date: | 2018-08-19 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.414 Å) | Cite: | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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4JR6
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![BU of 4jr6 by Molmil](/molmil-images/mine/4jr6) | Crystal structure of DsbA from Mycobacterium tuberculosis (reduced) | Descriptor: | Possible conserved membrane or secreted protein, SULFATE ION | Authors: | Wang, L. | Deposit date: | 2013-03-21 | Release date: | 2013-07-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.902 Å) | Cite: | Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. Protein Cell, 4, 2013
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4JR4
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![BU of 4jr4 by Molmil](/molmil-images/mine/4jr4) | Crystal structure of Mtb DsbA (Oxidized) | Descriptor: | Possible conserved membrane or secreted protein, SULFATE ION | Authors: | Wang, L. | Deposit date: | 2013-03-21 | Release date: | 2013-07-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c. Protein Cell, 4, 2013
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6LR0
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![BU of 6lr0 by Molmil](/molmil-images/mine/6lr0) | structure of human bile salt exporter ABCB11 | Descriptor: | Bile salt export pump | Authors: | Wang, L, Hou, W.T, Chen, L, Jiang, Y.L, Xu, D, Sun, L.F, Zhou, C.Z, Chen, Y. | Deposit date: | 2020-01-15 | Release date: | 2020-04-15 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of human bile salts exporter ABCB11. Cell Res., 30, 2020
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1Y2M
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![BU of 1y2m by Molmil](/molmil-images/mine/1y2m) | Crystal structure of phenylalanine ammonia-lyase from yeast Rhododporidium toruloides | Descriptor: | Phenylalanine ammonia-lyase | Authors: | Wang, L, Gamez, A, Sarkissian, C.N, Straub, M, Patch, M.G, Han, G.W, Scriver, C.R, Stevens, R.C. | Deposit date: | 2004-11-22 | Release date: | 2005-11-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Mol.Genet.Metab., 86, 2005
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1ZOK
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![BU of 1zok by Molmil](/molmil-images/mine/1zok) | PDZ1 Domain Of Synapse Associated Protein 97 | Descriptor: | Presynaptic protein SAP97 | Authors: | Wang, L, Piserchio, A, Mierke, D.F. | Deposit date: | 2005-05-13 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Characterization of the Intermolecular Interactions of Synapse-associated Protein-97 with the NR2B Subunit of N-Methyl-D-aspartate Receptors. J.Biol.Chem., 280, 2005
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4NSC
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![BU of 4nsc by Molmil](/molmil-images/mine/4nsc) | Crystal Structure of CBARA1 in the Apo-form | Descriptor: | Calcium uptake protein 1, mitochondrial | Authors: | Wang, L, Yang, X, Li, S, Shen, Y. | Deposit date: | 2013-11-28 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J., 33, 2014
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4NSD
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![BU of 4nsd by Molmil](/molmil-images/mine/4nsd) | Crystal Structure of CBARA1 in the Ca2+ Binding Form | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Wang, L, Yang, X, Li, S, Shen, Y. | Deposit date: | 2013-11-28 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake. Embo J., 33, 2014
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8E6S
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![BU of 8e6s by Molmil](/molmil-images/mine/8e6s) | Human TRPM2 ion channel in 1 mM dADPR and Ca2+ | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, ... | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6V
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![BU of 8e6v by Molmil](/molmil-images/mine/8e6v) | MHR1/2 and NUDT9H of human TRPM2 in 1 mM dADPR (local refinement) | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, ZINC ION | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6U
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![BU of 8e6u by Molmil](/molmil-images/mine/8e6u) | Human TRPM2 ion channel in 1 mM F-dADPR | Descriptor: | Transient receptor potential cation channel subfamily M member 2, [(2R,3S,5R)-5-(6-amino-8-phenyl-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name) | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6Q
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![BU of 8e6q by Molmil](/molmil-images/mine/8e6q) | Human TRPM2 ion channel in 1 mM ADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6R
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![BU of 8e6r by Molmil](/molmil-images/mine/8e6r) | Human TRPM2 ion channel in 1 mM dADPR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8E6T
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![BU of 8e6t by Molmil](/molmil-images/mine/8e6t) | Human TRPM2 ion channel in 1 mM BR-ADPR | Descriptor: | (3R,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4,5-trihydroxypentyl [(2S,3S,4S,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2022-08-23 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A unified mechanism for human TRPM2 activation, desensitization and inhibition To Be Published
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8ERP
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![BU of 8erp by Molmil](/molmil-images/mine/8erp) | Structure of Xenopus cholinephosphotransferase1 in complex with CDP-choline | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Cholinephosphotransferase 1, MAGNESIUM ION, ... | Authors: | Wang, L, Zhou, M. | Deposit date: | 2022-10-12 | Release date: | 2023-04-26 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis. Nat Commun, 14, 2023
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8ERO
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![BU of 8ero by Molmil](/molmil-images/mine/8ero) | Structure of Xenopus cholinephosphotransferase1 in complex with CDP | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CYTIDINE-5'-DIPHOSPHATE, Cholinephosphotransferase 1, ... | Authors: | Wang, L, Zhou, M. | Deposit date: | 2022-10-12 | Release date: | 2023-04-26 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis. Nat Commun, 14, 2023
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6WM4
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![BU of 6wm4 by Molmil](/molmil-images/mine/6wm4) | Human V-ATPase in state 3 with SidK and ADP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Renin receptor, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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6WLZ
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![BU of 6wlz by Molmil](/molmil-images/mine/6wlz) | The V1 region of human V-ATPase in state 1 (focused refinement) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SidK, V-type proton ATPase catalytic subunit A, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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