8ET7
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![BU of 8et7 by Molmil](/molmil-images/mine/8et7) | Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8ET8
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![BU of 8et8 by Molmil](/molmil-images/mine/8et8) | Cryo-EM structure of the organic cation transporter 1 in complex with verapamil | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8ET9
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![BU of 8et9 by Molmil](/molmil-images/mine/8et9) | |
8ET6
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![BU of 8et6 by Molmil](/molmil-images/mine/8et6) | |
8FCB
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![BU of 8fcb by Molmil](/molmil-images/mine/8fcb) | Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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4PB1
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![BU of 4pb1 by Molmil](/molmil-images/mine/4pb1) | Structure of vcCNT-7C8C bound to ribavirin | Descriptor: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-11 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD5
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![BU of 4pd5 by Molmil](/molmil-images/mine/4pd5) | Crystal structure of vcCNT-7C8C bound to gemcitabine | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, GEMCITABINE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.906 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PDA
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![BU of 4pda by Molmil](/molmil-images/mine/4pda) | Structure of vcCNT-7C8C bound to cytidine | Descriptor: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.608 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD6
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![BU of 4pd6 by Molmil](/molmil-images/mine/4pd6) | Crystal structure of vcCNT-7C8C bound to uridine | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD8
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![BU of 4pd8 by Molmil](/molmil-images/mine/4pd8) | Structure of vcCNT-7C8C bound to pyrrolo-cytidine | Descriptor: | 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD9
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![BU of 4pd9 by Molmil](/molmil-images/mine/4pd9) | Structure of vcCNT-7C8C bound to adenosine | Descriptor: | ADENOSINE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.096 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PB2
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![BU of 4pb2 by Molmil](/molmil-images/mine/4pb2) | Structure of vcCNT-7C8C bound to 5-fluorouridine | Descriptor: | 5-FLUOROURIDINE, DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-11 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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4PD7
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![BU of 4pd7 by Molmil](/molmil-images/mine/4pd7) | Structure of vcCNT bound to zebularine | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | Authors: | Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2014-04-17 | Release date: | 2014-08-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.909 Å) | Cite: | Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife, 3, 2014
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7STL
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![BU of 7stl by Molmil](/molmil-images/mine/7stl) | Chitin Synthase 2 from Candida albicans at the apo state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Chitin synthase | Authors: | Ren, Z, Chhetri, A, Lee, S, Yokoyama, K. | Deposit date: | 2021-11-14 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. Nat.Struct.Mol.Biol., 29, 2022
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7STO
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![BU of 7sto by Molmil](/molmil-images/mine/7sto) | Chitin Synthase 2 from Candida albicans bound to polyoxin D | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-{(2R,3R,4S,5R)-5-[(S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}(carboxy)methyl]-3,4-dihydroxyoxolan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (non-preferred name), Chitin synthase | Authors: | Ren, Z, Chhetri, A, Lee, S, Yokoyama, K. | Deposit date: | 2021-11-14 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. Nat.Struct.Mol.Biol., 29, 2022
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7STM
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![BU of 7stm by Molmil](/molmil-images/mine/7stm) | Chitin Synthase 2 from Candida albicans bound to UDP-GlcNAc | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Chitin synthase, MAGNESIUM ION, ... | Authors: | Ren, Z, Chhetri, A, Lee, S, Yokoyama, K. | Deposit date: | 2021-11-14 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. Nat.Struct.Mol.Biol., 29, 2022
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7STN
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![BU of 7stn by Molmil](/molmil-images/mine/7stn) | Chitin Synthase 2 from Candida albicans bound to Nikkomycin Z | Descriptor: | (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name), 1,2-Distearoyl-sn-glycerophosphoethanolamine, Chitin synthase | Authors: | Ren, Z, Chhetri, A, Lee, S, Yokoyama, K. | Deposit date: | 2021-11-14 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. Nat.Struct.Mol.Biol., 29, 2022
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4XL4
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![BU of 4xl4 by Molmil](/molmil-images/mine/4xl4) | Crystal structure of thiolase from Clostridium acetobutylicum in complex with CoA | Descriptor: | Acetyl-CoA acetyltransferase, COENZYME A, GLYCEROL | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2015-01-13 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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4XL2
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![BU of 4xl2 by Molmil](/molmil-images/mine/4xl2) | Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum | Descriptor: | ACETATE ION, Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2015-01-13 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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4XL3
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![BU of 4xl3 by Molmil](/molmil-images/mine/4xl3) | Crystal structure of reduced form of thiolase from Clostridium acetobutylicum | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2015-01-13 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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2X26
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![BU of 2x26 by Molmil](/molmil-images/mine/2x26) | Crystal structure of the periplasmic aliphatic sulphonate binding protein SsuA from Escherichia coli | Descriptor: | GLYCEROL, PERIPLASMIC ALIPHATIC SULPHONATES-BINDING PROTEIN | Authors: | Beale, J, Lee, S, Iwata, S, Beis, K. | Deposit date: | 2010-01-11 | Release date: | 2010-04-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the Aliphatic Sulfonate-Binding Protein Ssua from Escherichia Coli Acta Crystallogr.,Sect.F, 66, 2010
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6D73
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![BU of 6d73 by Molmil](/molmil-images/mine/6d73) | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ | Descriptor: | CALCIUM ION, Transient receptor potential cation channel, subfamily M | Authors: | Yin, Y, Wu, M, Borschel, W.F, Lander, G.C, Lee, S.-Y. | Deposit date: | 2018-04-23 | Release date: | 2019-05-15 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nat Commun, 10, 2019
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6DT0
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![BU of 6dt0 by Molmil](/molmil-images/mine/6dt0) | Cryo-EM structure of a mitochondrial calcium uniporter | Descriptor: | CALCIUM ION, Mitochondrial calcium uniporter | Authors: | Yoo, J, Wu, M, Yin, Y, Herzik, M.A.J, Lander, G.C, Lee, S.-Y. | Deposit date: | 2018-06-14 | Release date: | 2018-07-11 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of a mitochondrial calcium uniporter. Science, 361, 2018
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7XI1
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![BU of 7xi1 by Molmil](/molmil-images/mine/7xi1) | AcrIF 24 | Descriptor: | anti-CRISPR protein AcrIF24 | Authors: | Kim, G.E, Park, H.H. | Deposit date: | 2022-04-11 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24. Nucleic Acids Res., 50, 2022
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5U9W
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![BU of 5u9w by Molmil](/molmil-images/mine/5u9w) | Structure of CNTnw N149L in the intermediate 3 state | Descriptor: | 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease | Authors: | Hirschi, M, Johnson, Z.L, Lee, S.-Y. | Deposit date: | 2016-12-18 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.555 Å) | Cite: | Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature, 545, 2017
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