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6IV4
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BU of 6iv4 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation W252F
Descriptor: Bestrophin homolog, ZINC ION
Authors:Kittredge, A, Chen, S, Yang, T.
Deposit date:2018-12-02
Release date:2019-11-13
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
6IV1
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BU of 6iv1 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation I180T
Descriptor: Bestrophin homolog, ZINC ION
Authors:Kittredge, A, Chen, S, Yang, T.
Deposit date:2018-12-02
Release date:2019-11-13
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
6IV3
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BU of 6iv3 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation W252A
Descriptor: Bestrophin homolog, ZINC ION
Authors:Kittredge, A, Chen, S, Yang, T.
Deposit date:2018-12-02
Release date:2019-11-13
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.515 Å)
Cite:Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
5XUH
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BU of 5xuh by Molmil
Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS) D9A mutant in complex with CoA
Descriptor: CHLORIDE ION, COENZYME A, GLYCEROL, ...
Authors:Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S.
Deposit date:2017-06-23
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
5XUM
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BU of 5xum by Molmil
Crystal structure of Thermotoga maritima holo-[acyl-carrier-protein] synthase (AcpS)
Descriptor: GLYCEROL, Holo-[acyl-carrier-protein] synthase
Authors:Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S.
Deposit date:2017-06-23
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
5X87
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BU of 5x87 by Molmil
Crystal structure of a bacterial Bestrophin homolog from Klebsiella pneumoniae with a mutation L177T
Descriptor: Bestrophin, ZINC ION
Authors:Zhang, Y, Chen, S, Yang, T.
Deposit date:2017-03-01
Release date:2017-11-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca2+-dependent Cl-currents in human RPE.
Elife, 6, 2017
5XU7
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BU of 5xu7 by Molmil
Crystal structure of Escherichia coli holo-[acyl-carrier-protein] synthase (AcpS)
Descriptor: CHLORIDE ION, GLYCEROL, Holo-[acyl-carrier-protein] synthase
Authors:Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S.
Deposit date:2017-06-22
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
5XUK
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BU of 5xuk by Molmil
Crystal structure of Helicobacter pylori holo-[acyl-carrier-protein] synthase (AcpS) in complex with coenzyme A
Descriptor: COENZYME A, Holo-[acyl-carrier-protein] synthase
Authors:Liao, Y.P, Wang, D.L, Yin, D.P, Zhang, Q.Y, Wang, Y.M, Wang, D.Q, Zhu, H.X, Chen, S.
Deposit date:2017-06-23
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of acyl carrier protein synthases (AcpS) from three Gram-negative bacteria
To Be Published
7CI3
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BU of 7ci3 by Molmil
The crystal structure of the SARS-CoV-2 ORF7a ectodomain
Descriptor: Orf7a protein
Authors:Zhou, Z, Zhou, Z, Chen, S.
Deposit date:2020-07-07
Release date:2021-03-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14 + monocytes.
Iscience, 24, 2021
7DWS
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BU of 7dws by Molmil
The structure of T4 Lysozyme I3C/C54T/R125C/E128C complex with Zinc ions
Descriptor: Endolysin, ZINC ION
Authors:Chen, X, Chen, S.
Deposit date:2021-01-17
Release date:2021-06-02
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rationally designed protein cross-linked hydrogel for bone regeneration via synergistic release of magnesium and zinc ions.
Biomaterials, 274, 2021
3R8W
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BU of 3r8w by Molmil
Structure of 3-isopropylmalate dehydrogenase isoform 2 from Arabidopsis thaliana at 2.2 angstrom resolution
Descriptor: 3-isopropylmalate dehydrogenase 2, chloroplastic, ACETATE ION
Authors:He, Y, Galant, A, Pang, Q, Strul, J.M, Balogun, S, Jez, J.M, Chen, S.
Deposit date:2011-03-24
Release date:2011-06-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana.
J.Biol.Chem., 286, 2011
3QB5
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BU of 3qb5 by Molmil
Human C3PO complex in the presence of MnSO4
Descriptor: CHLORIDE ION, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Ye, X, Huang, N, Liu, Y, Paroo, Z, Chen, S, Zhang, H, Liu, Q.
Deposit date:2011-01-12
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of C3PO and mechanism of human RISC activation.
Nat.Struct.Mol.Biol., 18, 2011
7DRI
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BU of 7dri by Molmil
Structure of SspE_CTD_41658
Descriptor: DUF1524 domain
Authors:Haiyan, G, Jinchuan, Z, Chen, S, Wang, L, Wu, G.
Deposit date:2020-12-28
Release date:2022-06-29
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.
Nat Commun, 13, 2022
7DB7
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BU of 7db7 by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001
Descriptor: 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
Authors:Xu, M, Zhang, X, Xu, L, Chen, S.
Deposit date:2020-10-19
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DRS
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BU of 7drs by Molmil
Structure of SspE_40224
Descriptor: SspE protein
Authors:Haiyan, G, Jinchuan, Z, Chen, S, Wang, L, Wu, G.
Deposit date:2020-12-29
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.
Nat Commun, 13, 2022
7DRR
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BU of 7drr by Molmil
Structure of SspE-R100A protein
Descriptor: SspE protein
Authors:Haiyan, G, Jinchuan, Z, Chen, S, Wang, L, Wu, G.
Deposit date:2020-12-29
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE.
Nat Commun, 13, 2022
7DAW
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BU of 7daw by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase
Descriptor: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, SULFATE ION
Authors:Xu, M, Zhang, X, Xu, L, Chen, S.
Deposit date:2020-10-18
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DB8
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BU of 7db8 by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845
Descriptor: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
Authors:Xu, M, Zhang, X, Xu, L, Chen, S.
Deposit date:2020-10-19
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DK2
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BU of 7dk2 by Molmil
Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MW07 heavy chain, MW07 light chain, ...
Authors:Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M, Chen, S.
Deposit date:2020-11-22
Release date:2021-12-08
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Architectural versatility of spike neutralization by a SARS-CoV-2 antibody
To Be Published
7EL8
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BU of 7el8 by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase
Descriptor: Tryptophan--tRNA ligase
Authors:Xu, M, Chen, S.
Deposit date:2021-04-09
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022
7ENS
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BU of 7ens by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Indolmycin and ATP
Descriptor: (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Xu, M, Chen, S.
Deposit date:2021-04-19
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022
7ELT
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BU of 7elt by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Trp-AMP
Descriptor: TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase
Authors:Xu, M, Chen, S.
Deposit date:2021-04-12
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022
7ENT
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BU of 7ent by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-13 and ATP
Descriptor: (5S)-2-(methylamino)-5-[(1R)-1-(4-methyl-1H-indol-3-yl)ethyl]-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Xu, M, Chen, S.
Deposit date:2021-04-19
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022
7EV3
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BU of 7ev3 by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-10 and ATP
Descriptor: (5S)-5-[(1R)-1-(4-fluoranyl-1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Xu, M, Chen, S.
Deposit date:2021-05-20
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022
7EV2
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BU of 7ev2 by Molmil
Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-11 and ATP
Descriptor: (5S)-5-[(1R)-1-(4-chloranyl-1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Xu, M, Chen, S.
Deposit date:2021-05-20
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
Acs Chem.Biol., 17, 2022

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