8XJ6
 
 | | The Cryo-EM structure of MPXV E5 apo conformation | | Descriptor: | AMP PHOSPHORAMIDATE, Monkeypox virus E5, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Zhang, W, Liu, Y, Gao, H, Gan, J. | | Deposit date: | 2023-12-20 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Structural and functional insights into the helicase protein E5 of Mpox virus.
Cell Discov, 10, 2024
|
|
8XIG
 | | The crystal structure of the AEP domain of MPXV E5 | | Descriptor: | MAGNESIUM ION, PYROPHOSPHATE, Uncoating factor OPG117 | | Authors: | Gan, J, Zhang, W. | | Deposit date: | 2023-12-19 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural and functional insights into the helicase protein E5 of Mpox virus.
Cell Discov, 10, 2024
|
|
8XJ7
 | | The Cryo-EM structure of MPXV E5 in complex with DNA | | Descriptor: | DNA (70-MER), MAGNESIUM ION, Monkeypox virus E5, ... | | Authors: | Zhang, W, Liu, Y, Gao, H, Gan, J. | | Deposit date: | 2023-12-20 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural and functional insights into the helicase protein E5 of Mpox virus.
Cell Discov, 10, 2024
|
|
6AVO
 | | Cryo-EM structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes | | Descriptor: | N~1~-{2-[([1,1'-biphenyl]-3-carbonyl)amino]ethyl}-N~4~-tert-butyl-N~2~-(3-phenylpropanoyl)-L-aspartamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | | Authors: | Li, H, Santos, R, Bai, L. | | Deposit date: | 2017-09-04 | | Release date: | 2017-12-06 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nat Commun, 8, 2017
|
|
5ZNJ
 | | Crystal structure of a bacterial ProRS with ligands | | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Cheng, B, Yu, Y, Zhou, H. | | Deposit date: | 2018-04-09 | | Release date: | 2019-05-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.
J.Med.Chem., 65, 2022
|
|
5ZNK
 | | Crystal structure of a bacterial ProRS with ligands | | Descriptor: | 7-chloro-6-fluoro-3-{2-oxo-3-[(2S)-piperidin-2-yl]propyl}quinazolin-4(3H)-one, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Cheng, B, Yu, Y, Zhou, H. | | Deposit date: | 2018-04-09 | | Release date: | 2019-05-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.
J.Med.Chem., 65, 2022
|
|
6BCX
 | | mTORC1 structure refined to 3.0 angstroms | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, MAGNESIUM ION, ... | | Authors: | Pavletich, N.P, Yang, H. | | Deposit date: | 2017-10-20 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
|
|
6BCU
 | |
8YYU
 | | A tetrameric STAT1-DNA complex | | Descriptor: | DNA (5'-D(P*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*TP*G)-3'), Signal transducer and activator of transcription 1-alpha/beta | | Authors: | Sugiyama, A, Minami, M, Sugita, Y, Ose, T. | | Deposit date: | 2024-04-04 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein.
Sci.Signal., 18, 2025
|
|
8YYV
 | | A dimeric STAT1-DNA complex | | Descriptor: | DNA (5'-D(P*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*TP*G)-3'), Signal transducer and activator of transcription 1-alpha/beta | | Authors: | Sugiyama, A, Minami, M, Sugita, Y, Ose, T. | | Deposit date: | 2024-04-04 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein.
Sci.Signal., 18, 2025
|
|
8YM1
 | | Structure of SADS-CoV Virus Nucleocapsid Protein | | Descriptor: | nucleocapsid phosphoprotein | | Authors: | Zhang, Y, Wu, F, Xu, W. | | Deposit date: | 2024-03-08 | | Release date: | 2024-07-24 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Unraveling the assembly mechanism of SADS-CoV virus nucleocapsid protein: insights from RNA binding, dimerization, and epitope diversity profiling.
J.Virol., 98, 2024
|
|
7C20
 | |
7VWP
 | | Structure of the flavin-dependent monooxygenase FlsO1 from the biosynthesis of fluostatinsin | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FlsO1, PHOSPHATE ION, ... | | Authors: | Zhang, Y, Yang, C, Zhang, L, Zhang, C. | | Deposit date: | 2021-11-11 | | Release date: | 2022-09-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation
Nat Commun, 13, 2022
|
|
7EO9
 | | Crystal structure of KIF1A Motor-Neck domain with ADP-Mg-AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF1A, ... | | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | | Deposit date: | 2021-04-21 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle.
Embo J., 41, 2022
|
|
7EOB
 | | Crystal structure of KIF1A Motor-Neck domain E239K mutant with ADP-Mg-AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF1A, ... | | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | | Deposit date: | 2021-04-21 | | Release date: | 2021-12-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle.
Embo J., 41, 2022
|
|
