6IJH
| Crystal structure of PDE10 in complex with inhibitor AF-399/14387019 | Descriptor: | 2-[2-(4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, MAGNESIUM ION, ZINC ION, ... | Authors: | Huang, Y.Y, Yu, Y.F, Zhang, C, Wu, D, Wu, Y, Luo, H.B. | Deposit date: | 2018-10-10 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. J. Med. Chem., 62, 2019
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4K97
| Structure of Ternary Complex of cGAS with dsDNA and Bound ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
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4K9A
| Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pG(2 ,5 )pA | Descriptor: | ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.264 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
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4K99
| Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG | Descriptor: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 3'-deoxy-guanosine 5'-monophosphate, Cyclic GMP-AMP synthase, ... | Authors: | Gao, P, Wu, Y, Patel, D.J. | Deposit date: | 2013-04-19 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
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1CS7
| SYNTHETIC DNA HAIRPIN WITH STILBENEDIETHER LINKER | Descriptor: | 5'-D(GP*(BRU)P*TP*TP*TP*GP*(S02)*CP*AP*AP*AP*AP*C)-3', STRONTIUM ION | Authors: | Lewis, F.D, Liu, X, Wu, Y, Miller, S.E, Wasielewski, M.R, Letsinger, R.L, Sanishvili, R, Joachimiak, A, Tereshko, V, Egli, M. | Deposit date: | 1999-08-17 | Release date: | 2001-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and Photoinduced Electron Transfer in Exceptionally Stable Synthetic DNA Hairpins with Stilbenediether Linkers J.Am.Chem.Soc., 121, 1999
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4QN7
| Crystal structure of neuramnidase N7 complexed with Oseltamivir | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | Deposit date: | 2014-06-17 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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1RII
| Crystal structure of phosphoglycerate mutase from M. Tuberculosis | Descriptor: | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, GLYCEROL | Authors: | Mueller, P, Sawaya, M.R, Chan, S, Wu, Y, Pashkova, I, Perry, J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2003-11-17 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase. Acta Crystallogr.,Sect.D, 61, 2005
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1TQE
| Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 | Descriptor: | Histone deacetylase 9, MEF2 binding site of nur77 promoter, Myocyte-specific enhancer factor 2B | Authors: | Chen, L, Han, A, He, J, Wu, Y, Liu, J.O. | Deposit date: | 2004-06-17 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanism of Recruitment of Class II Histone Deacetylases by Myocyte Enhancer Factor-2. J.Mol.Biol., 345, 2005
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4QN6
| Crystal structure of Neuraminidase N6 complexed with Laninamivir | Descriptor: | 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, Neuraminidase, ... | Authors: | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | Deposit date: | 2014-06-17 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN3
| Crystal structure of Neuraminidase N7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | Deposit date: | 2014-06-17 | Release date: | 2014-07-30 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN5
| Neuraminidase N5 binds LSTa at the second SIA binding site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | Deposit date: | 2014-06-17 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN4
| Crystal structure of Neuraminidase N6 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, GLYCEROL, ... | Authors: | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | Deposit date: | 2014-06-17 | Release date: | 2014-07-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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6MHN
| Photoactive Yellow Protein with covalently bound 3-chloro-4-hydroxycinnamic acid chromophore | Descriptor: | (2E)-3-(3-chloro-4-hydroxyphenyl)prop-2-enoic acid, Photoactive yellow protein | Authors: | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | Deposit date: | 2018-09-18 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation. J.Phys.Chem.B, 123, 2019
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6MHI
| Photoactive Yellow Protein with covalently bound 3,5-dichloro-4-hydroxycinnamic acid chromophore | Descriptor: | (2E)-3-(3,5-dichloro-4-hydroxyphenyl)prop-2-enoic acid, Photoactive yellow protein | Authors: | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | Deposit date: | 2018-09-18 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation. J.Phys.Chem.B, 123, 2019
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6MKT
| Photoactive Yellow Protein with 3-chlorotyrosine substituted at position 42 | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | Authors: | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | Deposit date: | 2018-09-26 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation. J.Phys.Chem.B, 123, 2019
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6MMD
| Photoactive Yellow Protein with 3,5-dichlorotyrosine substituted at position 42 | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | Authors: | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | Deposit date: | 2018-09-30 | Release date: | 2019-05-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.228 Å) | Cite: | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation. J.Phys.Chem.B, 123, 2019
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6O3P
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6OIX
| Structure of Escherichia coli dGTPase bound to GTP | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION | Authors: | Barnes, C.O, Wu, Y, Calero, G. | Deposit date: | 2019-04-09 | Release date: | 2019-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity. Proc.Natl.Acad.Sci.USA, 116, 2019
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5AQ8
| DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, OFF7_DB12V4, THIOCYANATE ION | Authors: | Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A. | Deposit date: | 2015-09-21 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography J.Mol.Biol., 428, 2016
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6OIV
| XFEL structure of Escherichia coli dGTPase | Descriptor: | Deoxyguanosinetriphosphate triphosphohydrolase, MANGANESE (II) ION, SULFATE ION | Authors: | Barnes, C.O, Wu, Y, Calero, G. | Deposit date: | 2019-04-09 | Release date: | 2019-06-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity. Proc.Natl.Acad.Sci.USA, 116, 2019
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2JY9
| NMR structure of putative tRNA hydrolase domain from Salmonella typhimurium. NorthEast Structural Genomics Consortium target StR220 | Descriptor: | Putative tRNA hydrolase domain | Authors: | Singarapu, K.K, Wu, Y, Sukumaran, D, Eletsky, A, Zeri, A, Wang, D, Janjua, H, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-12-07 | Release date: | 2008-01-01 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR structure of putative tRNA hydrolase domain from Salmonella typhimurium. To be Published
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2JS3
| NMR Structure of protein Q6N9A4_RHOPA. Northeast Structural Genomics Consortium target RpT8 | Descriptor: | Uncharacterized protein | Authors: | Singarapu, K.K, Wu, Y, Yee, A, Eletsky, A, Sukumaran, D, Garcia, M, Xiao, R, Bansal, S, Baran, M.C, Montelione, G.T, James, P.H, Arrowsmith, C.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-29 | Release date: | 2007-07-31 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR structure of protein Q6N9A4_RHOPA. To be Published
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5AAO
| Crystal structure of fluorogen-activating designed ankyrin repeat protein (DARPin) dimer in complex with malachite green | Descriptor: | 4-[[4-(dimethylamino)cyclohexa-2,5-dien-1-ylidene]-(4-methoxyphenyl)methyl]-N,N-dimethyl-aniline, FAD3210 | Authors: | Batyuk, A, Schuetz, M, Kummer, L, Wu, Y, Mittl, P, Plueckthun, A. | Deposit date: | 2015-07-27 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools. J. Mol. Biol., 428, 2016
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2JS5
| NMR Structure of protein Q60C73_METCA. Northeast Structural Genomics Consortium target McR1 | Descriptor: | Uncharacterized protein | Authors: | Singarapu, K.K, Wu, Y, Eletsky, A, Sukumaran, D, Parish, D, Chen, C.X, Nwosu, C, Maglaqui, M, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-29 | Release date: | 2007-07-31 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR Structure of protein Q60C73_METCA. To be Published
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2JR6
| Solution structure of UPF0434 protein NMA0874. Northeast Structural Genomics Target MR32 | Descriptor: | UPF0434 protein NMA0874 | Authors: | Ghosh, A, Singarapu, K.K, Wu, Y, Liu, G, Sukumaran, D, Chen, C.X, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-20 | Release date: | 2007-07-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of UPF0434 protein NMA0874. To be Published
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