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2JBY
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BU of 2jby by Molmil
A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2
分子名称: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, M11L PROTEIN, SODIUM ION
著者Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M.
登録日2006-12-14
公開日2007-03-27
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007
2JBX
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BU of 2jbx by Molmil
Crystal Structure of the myxoma virus anti-apoptotic protein M11L
分子名称: M11L PROTEIN
著者Kvansakul, M, Van Delft, M.F, Lee, E.F, Gulbis, J.M, Fairlie, W.D, Huang, D.C.S, Colman, P.M.
登録日2006-12-14
公開日2007-03-27
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JM6
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BU of 2jm6 by Molmil
Solution structure of MCL-1 complexed with NOXAB
分子名称: Myeloid cell leukemia-1 protein Mcl-1 homolog, Noxa
著者Czabotar, P.E, Lee, E.F, van Delft, M.F, Day, C.L, Smith, B.J, Huang, D.C.S, Fairlie, W.D, Hinds, M.G, Colman, P.M.
登録日2006-10-17
公開日2007-03-20
最終更新日2023-12-20
実験手法SOLUTION NMR
主引用文献Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
6MCY
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BU of 6mcy by Molmil
Crystal structure of mouse Bak
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, FORMIC ACID
著者Brouwer, J.M, Czabotar, P.E, Colman, P.M.
登録日2018-09-03
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Nat.Chem.Biol., 15, 2019
6O5Z
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BU of 6o5z by Molmil
Crystal Structure of the human MLKL pseudokinase domain bound to compound 2
分子名称: 1,2-ETHANEDIOL, 1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea, Mixed lineage kinase domain-like protein
著者Cowan, A.D, Murphy, J.M, Pierotti, C.L, Lessene, G.L, Czabotar, P.E.
登録日2019-03-04
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.285 Å)
主引用文献Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.
Acs Chem.Biol., 15, 2020
5VWV
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BU of 5vwv by Molmil
Bak core latch dimer in complex with Bim-BH3 - Cubic
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX2
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BU of 5vx2 by Molmil
Mcl-1 in complex with Bim-h3Pc-RT
分子名称: 1,2-ETHANEDIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog,Induced myeloid leukemia cell differentiation protein Mcl-1 chimera
著者Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX0
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Bak in complex with Bim-h3Glg
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, ...
著者Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWW
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BU of 5vww by Molmil
Bak core latch dimer in complex with Bim-RT - Tetragonal
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BROMIDE ION, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.802 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX1
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BU of 5vx1 by Molmil
Bak L100A
分子名称: Bcl-2 homologous antagonist/killer
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.224 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWY
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BU of 5vwy by Molmil
Bak core latch dimer in complex with Bim-h3Pc-RT
分子名称: Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11, PHOSPHATE ION
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.555 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VX3
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BU of 5vx3 by Molmil
Bcl-xL in complex with Bim-h3Pc-RT
分子名称: 1,2-ETHANEDIOL, Bcl-2-like protein 1, Bcl-2-like protein 11
著者Cowan, A.D, Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.945 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWZ
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BU of 5vwz by Molmil
Bak in complex with Bim-h3Pc
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, AMMONIUM ION, Bcl-2 homologous antagonist/killer, ...
著者Brouwer, J.M, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.622 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
5VWX
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BU of 5vwx by Molmil
Bak core latch dimer in complex with Bim-h0-h3Glt
分子名称: 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 11
著者Brouwer, J.M, Lan, P, Lessene, G, Colman, P.M, Czabotar, P.E.
登録日2017-05-23
公開日2017-11-15
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.489 Å)
主引用文献Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Mol. Cell, 68, 2017
3VPP
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BU of 3vpp by Molmil
Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain
分子名称: C-type lectin domain family 9 member A, CALCIUM ION
著者Czabotar, P.E, Zhang, J.G, Policheni, A.N, Shortman, K, Lahoud, M.H, Colman, P.M.
登録日2012-03-07
公開日2012-04-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.642 Å)
主引用文献The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
分子名称: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
著者Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
登録日2008-05-22
公開日2008-06-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
2NL9
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BU of 2nl9 by Molmil
Crystal structure of the Mcl-1:Bim BH3 complex
分子名称: Bcl-2-like protein 11, CHLORIDE ION, FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, ...
著者Czabotar, P.E, Colman, P.M.
登録日2006-10-19
公開日2007-03-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
2NLA
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BU of 2nla by Molmil
Crystal structure of the Mcl-1:mNoxaB BH3 complex
分子名称: FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Phorbol-12-myristate-13-acetate-induced protein 1
著者Czabotar, P.E, Colman, P.M.
登録日2006-10-19
公開日2007-03-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007

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