6O5Z

Crystal Structure of the human MLKL pseudokinase domain bound to compound 2

Summary for 6O5Z

• Entry DOI: 10.2210/pdb6o5z/pdb
• Descriptor: Mixed lineage kinase domain-like protein, 1,2-ETHANEDIOL, 1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea, ... (4 entities in total)
• Functional Keywords: pseudokinase, inhibitor, necroptosis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 66359.38

Authors

Cowan, A.D.,Murphy, J.M.,Pierotti, C.L.,Lessene, G.L.,Czabotar, P.E. (deposition date: 2019-03-04, release date: 2020-09-16, Last modification date: 2023-10-11)

• Primary citation: Pierotti, C.L.,Tanzer, M.C.,Jacobsen, A.V.,Hildebrand, J.M.,Garnier, J.M.,Sharma, P.,Lucet, I.S.,Cowan, A.D.,Kersten, W.J.A.,Luo, M.X.,Liang, L.Y.,Fitzgibbon, C.,Garnish, S.E.,Hempel, A.,Nachbur, U.,Huang, D.C.S.,Czabotar, P.E.,Silke, J.,van Delft, M.F.,Murphy, J.M.,Lessene, G.; Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.; Acs Chem.Biol., 15:2702-2713, 2020; PubMed: 32902249; DOI: 10.1021/acschembio.0c00482

Experimental method

X-RAY DIFFRACTION (2.285 Å)