6O5Z
Crystal Structure of the human MLKL pseudokinase domain bound to compound 2
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | GLU250 |
| A | GLY349 |
| A | HOH631 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ALA228 |
| A | GLU284 |
| A | CYS286 |
| A | LEU338 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR387 |
| A | GLU381 |
| A | ASP384 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | THR340 |
| A | GLY342 |
| B | THR340 |
| B | GLY342 |
| B | GLN344 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue LN4 B 501 |
| Chain | Residue |
| B | LEU209 |
| B | ARG210 |
| B | LEU217 |
| B | ALA228 |
| B | GLU250 |
| B | THR253 |
| B | MET283 |
| B | GLU284 |
| B | TYR285 |
| B | CYS286 |
| B | GLU293 |
| B | HIS329 |
| B | LEU338 |
| B | LEU347 |
| B | ALA348 |
| B | GLY349 |
| B | PHE350 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | PRO379 |
| B | VAL424 |
| B | ARG428 |
| B | GLN430 |
| B | ARG449 |
| B | HIS451 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by RIPK3","evidences":[{"source":"PubMed","id":"22265413","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by RIPK3","evidences":[{"source":"PubMed","id":"22265413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29883610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
