6O5Z
Crystal Structure of the human MLKL pseudokinase domain bound to compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mixed lineage kinase domain-like protein | polymer | 287 | 32736.8 | 2 | UniProt (Q8NB16) Pfam (PF07714) | Homo sapiens (Human) | hMLKL |
| 2 | C, D, E, F, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | G (B) | 1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea | non-polymer | 575.5 | 1 | Chemie (LN4) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 190 - 471 (UniProt: Q8NB16)
| PDB | External Database | Details |
|---|---|---|
| Gly 185 | - | expression tag |
| Ala 186 | - | expression tag |
| Met 187 | - | expression tag |
| Gly 188 | - | expression tag |
| Ser 189 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65473.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 885.9 | |
| All* | Total formula weight | 66359.4 |
