5L73
| MAM domain of human neuropilin-1 | 分子名称: | BICINE, CALCIUM ION, Neuropilin-1, ... | 著者 | Yelland, T, Djordjevic, S. | 登録日 | 2016-06-01 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture. Structure, 24, 2016
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7OK6
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7OK7
| Crystal structure of the UNC119B ARL3 complex | 分子名称: | 1,2-ETHANEDIOL, ADP-ribosylation factor-like protein 3, GLYCEROL, ... | 著者 | Yelland, T, Ismail, S. | 登録日 | 2021-05-17 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms. Biochemistry, 60, 2021
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7AJK
| Crystal structure of CRYI-B Rac1 complex | 分子名称: | CYFIP-related Rac1 interactor B, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Yelland, T, Anh, L, Insall, R, Machesky, L, Ismail, S. | 登録日 | 2020-09-29 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. Structure, 29, 2021
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7AJL
| Cyrstal structure of CYRI-B/Fam49B | 分子名称: | CYFIP-related Rac1 interactor B | 著者 | Yelland, T, Anh, H, Insall, R, Machesky, L, Ismail, S. | 登録日 | 2020-09-29 | 公開日 | 2020-11-18 | 最終更新日 | 2021-06-02 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1. Structure, 29, 2021
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7Q9S
| Crystal structure of PDE6D KRas peptide complex with Compound-1 | 分子名称: | 1,2-ETHANEDIOL, 2-methyl-3-(1~{H}-pyrazol-5-yl)imidazo[1,2-a]pyridine, DIMETHYL SULFOXIDE, ... | 著者 | Yelland, T, Ismail, S. | 登録日 | 2021-11-14 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7Q9Q
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7Q9R
| Cocrystal structure of PDE6D bound to NRAS peptide | 分子名称: | 1,2-ETHANEDIOL, FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ... | 著者 | Yelland, T, Ismail, S. | 登録日 | 2021-11-14 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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7QF9
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7Q9U
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7QJK
| Crystal structure of PDE6D in complex with Compound-2 | 分子名称: | 1,2-ETHANEDIOL, N-(phenylmethyl)pyridin-2-amine, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ... | 著者 | Yelland, T, Ismail, S. | 登録日 | 2021-12-16 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling. J.Med.Chem., 65, 2022
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6FMC
| Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | 著者 | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | 登録日 | 2018-01-30 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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6FMF
| Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid | 著者 | Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P. | 登録日 | 2018-01-31 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.811 Å) | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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6H6A
| Crystal structure of UNC119 in complex with LCK peptide | 分子名称: | GLY-CYS-GLY-CYS-SER-SER, GLYCEROL, MYRISTIC ACID, ... | 著者 | Yelland, T, ElMaghloob, Y, McIlwraith, M, Stephen, L, Ismail, S. | 登録日 | 2018-07-26 | 公開日 | 2018-09-26 | 最終更新日 | 2019-11-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Dev.Cell, 47, 2018
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7P5U
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7ZC8
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6TDB
| Neuropilin2-b1 domain in a complex with the C-terminal VEGFB167 peptide | 分子名称: | 1,2-ETHANEDIOL, ACETYL GROUP, C-terminal VEGFB167 peptide, ... | 著者 | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | 登録日 | 2019-11-08 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | NRP2-b1 domain in a complex with the C-terminal VEGFB167 peptide To Be Published
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6TJT
| Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide | 分子名称: | 1,2-ETHANEDIOL, Neuropilin-2, SULFATE ION, ... | 著者 | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | 登録日 | 2019-11-26 | 公開日 | 2020-12-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | NRP2-b1 domain in a complex with the C-terminal VEGFC peptide To Be Published
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6TKK
| Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide | 分子名称: | 1,2-ETHANEDIOL, ACE-ARG-PRO-GLN-PRO-ARG, Neuropilin-1 | 著者 | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | 登録日 | 2019-11-28 | 公開日 | 2020-12-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide To Be Published
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5IJR
| X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand. | 分子名称: | DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1 | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-03-02 | 公開日 | 2017-03-29 | 最終更新日 | 2018-07-11 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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5IYY
| X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand. | 分子名称: | Neuropilin-1, N~2~-[(benzyloxy)carbonyl]-L-arginine | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-03-24 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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5J1X
| X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand. | 分子名称: | DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(tert-butoxycarbonyl)-L-arginine | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-03-29 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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5JGI
| X-ray structure of neuropilin-1 b1 domain complexed with M45 compound | 分子名称: | N-ALPHA-L-ACETYL-ARGININE, Neuropilin-1 | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-04-20 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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5JGQ
| X-ray structure of neuropilin-1 b1 domain complexed with Arg-7 ligand. | 分子名称: | DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(benzenecarbonyl)-L-arginine | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-04-20 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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5JHK
| X-ray structure of neuropilin-1 b1 domain complexed with Arg-6 ligand. | 分子名称: | N-(benzenecarbonyl)glycyl-L-arginine, Neuropilin-1 | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | 登録日 | 2016-04-21 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1. FEBS J., 285, 2018
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