6YUZ
 
 | | Homodimeric structure of the rBAT complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neutral and basic amino acid transport protein rBAT | | 著者 | Wu, D, Safarian, S, Michel, H. | | 登録日 | 2020-04-27 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6YUP
 | | Heterotetrameric structure of the rBAT-b(0,+)AT1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neutral and basic amino acid transport protein rBAT, ... | | 著者 | Wu, D, Safarian, S, Michel, H. | | 登録日 | 2020-04-27 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6YV1
 | | Structure of human b(0,+)AT1 | | 分子名称: | b(0,+)-type amino acid transporter 1 | | 著者 | Wu, D, Safarian, S, Michel, H. | | 登録日 | 2020-04-27 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7RM4
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7ES4
 | | the crystral structure of DndH-C-domain | | 分子名称: | DNA phosphorothioation-dependent restriction protein DptH | | 著者 | Wu, D. | | 登録日 | 2021-05-08 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
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7FAR
 | | Crystal structure of PDE5A in complex with inhibitor L12 | | 分子名称: | 5-[bis(fluoranyl)methoxy]-2-[(4-chlorophenyl)methyl]-10-(3-methoxypropyl)-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Wu, D, Huang, Y.Y, Luo, H.B. | | 登録日 | 2021-07-07 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.40006471 Å) | | 主引用文献 | Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
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7FAQ
 | | Crystal structure of PDE5A in complex with inhibitor L1 | | 分子名称: | 2-[(4-chlorophenyl)methyl]-5-methoxy-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Wu, D, Huang, Y.Y, Luo, H.B. | | 登録日 | 2021-07-07 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.200136 Å) | | 主引用文献 | Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
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7EXX
 | | The structure of DndG | | 分子名称: | DNA phosphorothioation-dependent restriction protein DptG, SODIUM ION | | 著者 | Wu, D, Wang, L. | | 登録日 | 2021-05-28 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
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9LSM
 | | The crystal structure of PDE5A with L9 | | 分子名称: | 1-[(13~{S},15~{R})-4-bromanyl-15-(3-chloranyl-4-methoxy-phenyl)-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaen-12-yl]ethanone, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Wu, D, Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2025-02-04 | | 公開日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors
Chin.Chem.Lett., 2025
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9LSL
 | | The crystal structure of PDE5A with L1 | | 分子名称: | (13~{S},15~{R})-15-(3-chloranyl-4-methoxy-phenyl)-12-ethanoyl-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaene-4-carbonitrile, MAGNESIUM ION, ZINC ION, ... | | 著者 | Wu, D, Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2025-02-04 | | 公開日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors
Chin.Chem.Lett., 2025
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3FCX
 | | Crystal structure of human esterase D | | 分子名称: | CALCIUM ION, MAGNESIUM ION, S-formylglutathione hydrolase | | 著者 | Wu, D, Li, Y, Song, G, Zhang, D, Shaw, N, Liu, Z.J. | | 登録日 | 2008-11-24 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of human esterase D: a potential genetic marker of retinoblastoma
Faseb J., 23, 2009
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5D7W
 | | Crystal structure of serralysin | | 分子名称: | CALCIUM ION, GLYCEROL, Serralysin, ... | | 著者 | Wu, D, Ran, T, Xu, D.Q, Wang, W. | | 登録日 | 2015-08-14 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structure of a thermostable serralysin from Serratia sp. FS14 at 1.1 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
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7N1F
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7N1D
 | | SARS-CoV-2 YLQ peptide-specific TCR pYLQ7 | | 分子名称: | pYLQ7 T cell receptor alpha chain, pYLQ7 T cell receptor beta chain | | 著者 | Wu, D, Mariuzza, R.A. | | 登録日 | 2021-05-27 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
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7N1E
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7N1C
 | | SARS-CoV-2 RLQ peptide-specific TCR pRLQ3 | | 分子名称: | pRLQ3 T cell receptor alpha chain, pRLQ3 T cell receptor beta chain | | 著者 | Wu, D, Mariuzza, R.A. | | 登録日 | 2021-05-27 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.881 Å) | | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
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7N1A
 | | SARS-CoV-2 YLQ peptide binds to HLA-A2 | | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | | 著者 | Wu, D, Mariuzza, R.A. | | 登録日 | 2021-05-27 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
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7N1B
 | | SARS-CoV-2 RLQ peptide binds to HLA-A2 | | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | | 著者 | Wu, D, Mariuzza, R.A. | | 登録日 | 2021-05-27 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.
Nat Commun, 13, 2022
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3B8W
 | | Crystal structure of Escherichia coli alaine racemase mutant E221P | | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | | 登録日 | 2007-11-02 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
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3B8T
 | | Crystal structure of Escherichia coli alaine racemase mutant P219A | | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | | 登録日 | 2007-11-02 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
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3B8U
 | | Crystal structure of Escherichia coli alaine racemase mutant E221A | | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | | 登録日 | 2007-11-02 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
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3B8V
 | | Crystal structure of Escherichia coli alaine racemase mutant E221K | | 分子名称: | Alanine racemase, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | 著者 | Wu, D, Hu, T, Zhang, L, Jiang, H, Shen, X. | | 登録日 | 2007-11-02 | | 公開日 | 2008-07-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
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2FIK
 | | Structure of a microbial glycosphingolipid bound to mouse CD1d | | 分子名称: | (2S,3R)-3-HYDROXY-2-(TETRADECANOYLAMINO)OCTADECYL ALPHA-D-GALACTOPYRANOSIDURONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, D, Zajonc, D.M. | | 登録日 | 2005-12-29 | | 公開日 | 2006-03-21 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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4YLW
 | | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound | | 分子名称: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Wu, D, Ouyang, P, Lu, W, Huang, J. | | 登録日 | 2015-03-06 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound
To Be Published
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4ZQD
 | | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with the Benzoxadiazole Antagonist 0X3 | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | | 著者 | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | | 登録日 | 2015-05-09 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
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