9LSL

The crystal structure of PDE5A with L1

This is a non-PDB format compatible entry.

Summary for 9LSL

• Entry DOI: 10.2210/pdb9lsl/pdb
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, (13~{S},15~{R})-15-(3-chloranyl-4-methoxy-phenyl)-12-ethanoyl-8,12,16-triazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,8-pentaene-4-carbonitrile, ZINC ION, ... (5 entities in total)
• Functional Keywords: pde5a, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38311.15

Authors

Wu, D.,Huang, Y.-Y.,Luo, H.-B. (deposition date: 2025-02-04, release date: 2025-06-18)

• Primary citation: Wu, D.,Ma, Q.,Chen, Y.,Yang, G.,Zhang, F.,Jiang, M.,Wang, X.,Liu, X.,Zhou, Q.,Huang, Y.Y.,Li, Z.,Luo, H.B.; Plasma metabolites-based drug design: Discovery of novel and highly selective phosphodiesterase 5 inhibitors; Chin.Chem.Lett., :111236-, 2025; DOI: 10.1016/j.cclet.2025.111236

Experimental method

X-RAY DIFFRACTION (2.5 Å)