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1U21
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transthyretin with tethered inhibitor on one monomer.
分子名称: 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin
著者Wiseman, R.L, Johnson, S.M, Kelker, M.S, Foss, T, Wilson, I.A, Kelly, J.W.
登録日2004-07-16
公開日2005-06-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Kinetic stabilization of an oligomeric protein by a single ligand binding event
J.Am.Chem.Soc., 127, 2005
6AZ0
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BU of 6az0 by Molmil
Mitochondrial ATPase Protease YME1
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Puchades, C, Rampello, A.J, Shin, M, Giuliano, C, Wiseman, R.L, Glynn, S.E, Lander, G.C.
登録日2017-09-09
公開日2017-11-15
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Science, 358, 2017
6V11
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BU of 6v11 by Molmil
Lon Protease from Yersinia pestis
分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease
著者Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C.
登録日2019-11-19
公開日2020-01-22
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
7SXO
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BU of 7sxo by Molmil
Yeast Lon (PIM1) with endogenous substrate
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
著者Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C.
登録日2021-11-24
公開日2022-01-12
最終更新日2022-07-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
J.Biol.Chem., 298, 2022
7KSL
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BU of 7ksl by Molmil
Substrate-free human mitochondrial LONP1
分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
著者Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
登録日2020-11-23
公開日2020-12-09
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7KSM
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Human mitochondrial LONP1 with endogenous substrate
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
著者Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
登録日2020-11-23
公開日2020-12-02
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
7KRZ
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Human mitochondrial LONP1 in complex with Bortezomib
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ...
著者Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C.
登録日2020-11-20
公開日2021-02-24
最終更新日2022-06-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
6ON2
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BU of 6on2 by Molmil
Lon Protease from Yersinia pestis with Y2853 substrate
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent protease La, ...
著者Shin, M, Asmita, A, Puchades, C, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C.
登録日2019-04-19
公開日2019-05-01
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
3LJ1
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IRE1 complexed with Cdk1/2 Inhibitor III
分子名称: 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1
著者Lee, K.P.K, Sicheri, F.
登録日2010-01-25
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
3LJ2
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IRE1 complexed with JAK Inhibitor I
分子名称: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Serine/threonine-protein kinase/endoribonuclease IRE1
著者Lee, K.P.K, Sicheri, F.
登録日2010-01-25
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
3LJ0
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IRE1 complexed with ADP and Quercetin
分子名称: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Lee, K.P.K, Sicheri, F.
登録日2010-01-25
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Mol.Cell, 38, 2010
3TCT
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BU of 3tct by Molmil
Structure of wild-type TTR in complex with tafamidis
分子名称: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin
著者Connelly, S, Kelly, J.W, Wilson, I.A.
登録日2011-08-09
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Proc.Natl.Acad.Sci.USA, 109, 2012
2F8I
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Human transthyretin (TTR) complexed with Benzoxazole
分子名称: 2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID, Transthyretin
著者Palaninathan, S.K, Mohamedmohaideen, N.N, Sacchettini, J.C, Kelly, J.W.
登録日2005-12-02
公開日2005-12-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action
Angew.Chem.Int.Ed.Engl., 42, 2003
1QWH
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BU of 1qwh by Molmil
a covalent dimer of transthyretin that affects the amyloid pathway
分子名称: Transthyretin
著者Foss, T, Kelker, M.S, Wilson, I.A.
登録日2003-09-02
公開日2004-09-14
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.
J.Mol.Biol., 347, 2005
4YDM
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BU of 4ydm by Molmil
High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate
分子名称: 2,6-dichloro-4-[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol, Transthyretin
著者Connelly, S, Bradbury, N.C.
登録日2015-02-22
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans.
J.Am.Chem.Soc., 137, 2015
4YDN
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BU of 4ydn by Molmil
High resolution crystal structure of human transthyretin bound to ligand and conjugates of 4-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate
分子名称: 2,6-dichloro-4-[5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol, 4-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenyl sulfurofluoridate, Transthyretin
著者Connelly, S, Bradbury, N.C.
登録日2015-02-22
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans.
J.Am.Chem.Soc., 137, 2015
6NYY
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human m-AAA protease AFG3L2, substrate-bound
分子名称: ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ...
著者Lander, G.C, Puchades, C.
登録日2019-02-12
公開日2019-05-22
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Mol.Cell, 75, 2019
2IFO
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BU of 2ifo by Molmil
MODEL-BUILDING STUDIES OF INOVIRUS: GENETIC VARIATIONS ON A GEOMETRIC THEME
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-08-08
公開日1994-11-30
最終更新日2024-02-21
実験手法FIBER DIFFRACTION
主引用文献Model-building studies of Inovirus: genetic variations on a geometric theme.
Int.J.Biol.Macromol., 12, 1990
1IFJ
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BU of 1ifj by Molmil
MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (3.3 Å)
主引用文献Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe.
J.Mol.Biol., 235, 1994
1IFK
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BU of 1ifk by Molmil
MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (5 Å)
主引用文献Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe.
J.Mol.Biol., 235, 1994
1IFL
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BU of 1ifl by Molmil
MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (5 Å)
主引用文献Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe.
J.Mol.Biol., 235, 1994
1IFM
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BU of 1ifm by Molmil
TWO FORMS OF PF1 INOVIRUS: X-RAY DIFFRACTION STUDIES ON A STRUCTURAL PHASE TRANSITION AND A CALCULATED LIBRATION NORMAL MODE OF THE ASYMMETRIC UNIT
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (3.3 Å)
主引用文献Two Forms of Pf1 Inovirus: X-Ray Diffraction Studies on a Structural Phase Transition and a Calculated Libration Normal Mode of the Asymmetric Unit
Phase Transitions, 39, 1992
1IFI
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BU of 1ifi by Molmil
MOLECULAR MODELS AND STRUCTURAL COMPARISONS OF NATIVE AND MUTANT CLASS I FILAMENTOUS BACTERIOPHAGES FF (FD, F1, M13), IF1 AND IKE
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (3.3 Å)
主引用文献Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe.
J.Mol.Biol., 235, 1994
1IFD
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BU of 1ifd by Molmil
MODEL-BUILDING STUDIES OF INOVIRUS: GENETIC VARIATIONS ON A GEOMETRIC THEME
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1992-02-16
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (4 Å)
主引用文献Model-building studies of Inovirus: genetic variations on a geometric theme.
Int.J.Biol.Macromol., 12, 1990
1IFN
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BU of 1ifn by Molmil
TWO FORMS OF PF1 INOVIRUS: X-RAY DIFFRACTION STUDIES ON A STRUCTURAL PHASE TRANSITION AND A CALCULATED LIBRATION NORMAL MODE OF THE ASYMMETRIC UNIT
分子名称: INOVIRUS
著者Marvin, D.A.
登録日1994-01-31
公開日1994-07-31
最終更新日2024-02-07
実験手法FIBER DIFFRACTION (4 Å)
主引用文献Two Forms of Pf1 Inovirus: X-Ray Diffraction Studies on a Structural Phase Transition and a Calculated Libration Normal Mode of the Asymmetric Unit
Phase Transitions, 39, 1992

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