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4YDM

High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate

Summary for 4YDM
Entry DOI10.2210/pdb4ydm/pdb
Related4YDN
DescriptorTransthyretin, 2,6-dichloro-4-[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]phenol (3 entities in total)
Functional Keywordstransthyretin, hormone transport protein, thyroxine, retinol, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28359.10
Authors
Connelly, S.,Bradbury, N.C. (deposition date: 2015-02-22, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citationBaranczak, A.,Liu, Y.,Connelly, S.,Du, W.G.,Greiner, E.R.,Genereux, J.C.,Wiseman, R.L.,Eisele, Y.S.,Bradbury, N.C.,Dong, J.,Noodleman, L.,Sharpless, K.B.,Wilson, I.A.,Encalada, S.E.,Kelly, J.W.
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans.
J.Am.Chem.Soc., 137:7404-7414, 2015
Cited by
PubMed: 26051248
DOI: 10.1021/jacs.5b03042
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.25 Å)
Structure validation

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