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3FBD
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BU of 3fbd by Molmil
Crystal structure of the nuclease domain of COLE7(D493Q mutant) in complex with an 18-BP duplex DNA
分子名称: 5'-D(*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DGP*DAP*DTP*DCP*DGP*DAP*DAP*DTP*DTP*DCP*DC)-3', Colicin-E7
著者Wang, Y.T, Doudeva, L.G, Yuan, H.S.
登録日2008-11-19
公開日2009-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Redesign of high-affinity nonspecific nucleases with altered sequence preference
To be Published
2IVK
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BU of 2ivk by Molmil
Crystal structure of the periplasmic endonuclease Vvn complexed with a 16-bp DNA
分子名称: 5'-D(*AP*AP*TP*TP*CP*GP*AP*TP*CP*GP *AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*CP*GP*AP*TP*CP *GP*AP*AP*TP*T)-3', 5'-D(*GP*AP*AP*TP*TP*CP*GP*AP*TP*CP *GP*AP*AP*TP*TP*C)-3', ...
著者Wang, Y.T, Yang, W.J, Li, C.L, Doudeva, L.G, Yuan, H.S.
登録日2006-06-14
公開日2007-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis for Sequence-Dependent DNA Cleavage by Nonspecific Endonucleases.
Nucleic Acids Res., 35, 2007
2IVH
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BU of 2ivh by Molmil
Crystal structure of the nuclease domain of ColE7 (H545Q mutant) in complex with an 18-bp duplex DNA
分子名称: 5'-D(*GP*GP*AP*AP*TP*TP*CP*GP*AP*TP *CP*GP*AP*AP*TP*TP*CP*C)-3', COLCIN-E7, ZINC ION
著者Wang, Y.T, Yang, W.J, Li, C.L, Doudeva, L.G, Yuan, H.S.
登録日2006-06-13
公開日2007-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for Sequence-Dependent DNA Cleavage by Nonspecific Endonucleases.
Nucleic Acids Res., 35, 2007
4IUF
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BU of 4iuf by Molmil
Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA
分子名称: 5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3', TAR DNA-binding protein 43
著者Kuo, P.H, Doudeva, L.G, Wang, Y.T, Yang, W.Z, Yuan, H.S.
登録日2013-01-21
公開日2014-01-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.752 Å)
主引用文献The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.
Nucleic Acids Res., 42, 2014
8YD7
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BU of 8yd7 by Molmil
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p12, Caspase-8, FAS-associated death domain protein, ...
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-19
公開日2024-05-15
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024
8YD8
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BU of 8yd8 by Molmil
Structure of FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8, FAS-associated death domain protein
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-19
公開日2024-05-15
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024
8YBX
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BU of 8ybx by Molmil
Structure of the FADD/Caspase-8/cFLIP death effector domain assembly
分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8 subunit p10, FAS-associated death domain protein
著者Lin, S.-C, Yang, C.-Y.
登録日2024-02-16
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Nat Commun, 15, 2024
3GIX
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BU of 3gix by Molmil
Crystal structure of human splicing factor dim2
分子名称: Thioredoxin-like protein 4B, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose
著者Jin, T.C, Guo, F, Zhang, Y.Z.
登録日2009-03-06
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Crystal structure of human splicing factor dim2
To be Published
3D2W
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BU of 3d2w by Molmil
Crystal structure of mouse TDP-43 RRM2 domain in complex with DNA
分子名称: DNA (5'-D(*DGP*DTP*DTP*DGP*DAP*DGP*DCP*DGP*DTP*DT)-3'), PHOSPHATE ION, TAR DNA-binding protein 43
著者Kuo, P.H, Yuan, H.S.
登録日2008-05-09
公開日2009-04-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural insights into TDP-43 in nucleic-acid binding and domain interactions
Nucleic Acids Res., 37, 2009
8GQU
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BU of 8gqu by Molmil
AK-42 inhibitor binding human ClC-2 TMD
分子名称: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2
著者Wang, L.
登録日2022-08-30
公開日2023-07-05
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42.
Nat Commun, 14, 2023
3S5B
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BU of 3s5b by Molmil
Crystal Structure of CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans
分子名称: Endonuclease G, MAGNESIUM ION
著者Yuan, H.S, Lin, J.L.J.
登録日2011-05-23
公開日2012-01-11
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.796 Å)
主引用文献Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans
J.Biol.Chem., 287, 2012
3V9W
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BU of 3v9w by Molmil
Crystal structure of RNase T in complex with a preferred ssDNA (TTA) with two Mg in the active site
分子名称: COBALT (II) ION, DNA (5'-D(*GP*CP*TP*TP*A)-3'), MAGNESIUM ION, ...
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3V9X
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BU of 3v9x by Molmil
Crystal structure of RNase T in complex with a preferred ssDNA (AAA) with two Mg in the active site
分子名称: DNA (5'-D(*TP*TP*AP*TP*AP*AP*A)-3'), MAGNESIUM ION, Ribonuclease T
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3VA0
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BU of 3va0 by Molmil
Crystal structure of RNase T in complex with a di-nucleotide product (GG) with one Mg in the active site
分子名称: COBALT (II) ION, DNA (5'-D(*GP*G)-3'), MAGNESIUM ION, ...
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3V9S
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BU of 3v9s by Molmil
Crystal structure of RNase T in complex with a product ssDNA (AAC) with one Mg in the active site
分子名称: COBALT (II) ION, DNA (5'-D(*TP*TP*AP*CP*AP*AP*C)-3'), MAGNESIUM ION, ...
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3V9Z
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BU of 3v9z by Molmil
Crystal structure of RNase T in complex with a product ssDNA (ACC) with one Mg in the active site
分子名称: COBALT (II) ION, DNA (5'-D(*TP*TP*AP*CP*AP*CP*C)-3'), MAGNESIUM ION, ...
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3V9U
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BU of 3v9u by Molmil
Crystal structure of RNase T in complex with a preferred ssDNA (AAT) with two Mg in the active site
分子名称: COBALT (II) ION, DNA (5'-D(*TP*TP*AP*CP*AP*AP*T)-3'), MAGNESIUM ION, ...
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
3VA3
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BU of 3va3 by Molmil
Crystal structure of RNase T in complex with a duplex DNA product (stem loop DNA with 2 nucleotide 3' overhang)
分子名称: COBALT (II) ION, DNA (5'-D(*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*TP*T)-3'), Ribonuclease T
著者Hsiao, Y.-Y, Yuan, H.S.
登録日2011-12-28
公開日2012-07-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.714 Å)
主引用文献How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes
Nucleic Acids Res., 40, 2012
7XJA
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BU of 7xja by Molmil
TMD masked refine map of human ClC-2
分子名称: Chloride channel protein 2
著者Wang, L.
登録日2022-04-15
公開日2023-05-17
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
7XF5
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BU of 7xf5 by Molmil
Full length human CLC-2 channel in apo state
分子名称: Chloride channel protein 2
著者Wang, L.
登録日2022-04-01
公開日2023-05-03
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
4Y0F
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BU of 4y0f by Molmil
Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA
分子名称: DNA (5'-D(*GP*TP*TP*GP*AP*GP*CP*GP*TP*T)-3'), TAR DNA-binding protein 43
著者Chiang, C.H, Kuo, P.H, Doudeva, L.G, Wang, Y.T, Yuan, H.S.
登録日2015-02-06
公開日2016-02-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.648 Å)
主引用文献Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation
Sci Rep, 6, 2016
4QN0
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BU of 4qn0 by Molmil
Crystal structure of the CPS-6 mutant Q130K
分子名称: Endonuclease G, mitochondrial, MAGNESIUM ION
著者Lin, J.L.J, Yuan, H.S.
登録日2014-06-17
公開日2015-06-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G
Cell Rep, 16, 2016

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