4IUF
Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA
Summary for 4IUF
Entry DOI | 10.2210/pdb4iuf/pdb |
Descriptor | TAR DNA-binding protein 43, 5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' (3 entities in total) |
Functional Keywords | rna recognition motif, rna binding, dna binding, splicing factor, transcription regulator-dna complex, protein-dna complex, transcription regulator/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13148 |
Total number of polymer chains | 2 |
Total formula weight | 11866.19 |
Authors | Kuo, P.H.,Doudeva, L.G.,Wang, Y.T.,Yang, W.Z.,Yuan, H.S. (deposition date: 2013-01-21, release date: 2014-01-29, Last modification date: 2024-02-28) |
Primary citation | Kuo, P.H.,Chiang, C.H.,Wang, Y.T.,Doudeva, L.G.,Yuan, H.S. The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids. Nucleic Acids Res., 42:4712-4722, 2014 Cited by PubMed: 24464995DOI: 10.1093/nar/gkt1407 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.752 Å) |
Structure validation
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