4IUF

Crystal Structure of Human TDP-43 RRM1 Domain in Complex with a Single-stranded DNA

Summary for 4IUF

• Entry DOI: 10.2210/pdb4iuf/pdb
• Descriptor: TAR DNA-binding protein 43, 5'-D(*GP*TP*TP*GP*(XUA)P*GP*CP*GP*T)-3' (3 entities in total)
• Functional Keywords: rna recognition motif, rna binding, dna binding, splicing factor, transcription regulator-dna complex, protein-dna complex, transcription regulator/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q13148
• Total number of polymer chains: 2
• Total formula weight: 11866.19

Authors

Kuo, P.H.,Doudeva, L.G.,Wang, Y.T.,Yang, W.Z.,Yuan, H.S. (deposition date: 2013-01-21, release date: 2014-01-29, Last modification date: 2024-02-28)

• Primary citation: Kuo, P.H.,Chiang, C.H.,Wang, Y.T.,Doudeva, L.G.,Yuan, H.S.; The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.; Nucleic Acids Res., 42:4712-4722, 2014; PubMed: 24464995; DOI: 10.1093/nar/gkt1407

Experimental method

X-RAY DIFFRACTION (2.752 Å)