4OMF
| The F420-reducing [NiFe]-hydrogenase complex from Methanothermobacter marburgensis, the first X-ray structure of a group 3 family member | 分子名称: | CHLORIDE ION, F420-reducing hydrogenase, subunit alpha, ... | 著者 | Vitt, S, Ma, K, Warkentin, E, Moll, J, Pierik, A, Shima, S, Ermler, U. | 登録日 | 2014-01-27 | 公開日 | 2014-06-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | The F420-Reducing [NiFe]-Hydrogenase Complex from Methanothermobacter marburgensis, the First X-ray Structure of a Group 3 Family Member. J.Mol.Biol., 426, 2014
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7ZC6
| Na+ - translocating ferredoxin: NAD+ reductase (Rnf) of C. tetanomorphum | 分子名称: | FE (III) ION, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ... | 著者 | Ermler, U, Vitt, S, Buckel, W. | 登録日 | 2022-03-25 | 公開日 | 2022-09-28 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Purification and structural characterization of the Na + -translocating ferredoxin: NAD + reductase (Rnf) complex of Clostridium tetanomorphum. Nat Commun, 13, 2022
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3ZFS
| Cryo-EM structure of the F420-reducing NiFe-hydrogenase from a methanogenic archaeon with bound substrate | 分子名称: | CARBONMONOXIDE-(DICYANO) IRON, COENZYME F420, F420-REDUCING HYDROGENASE, ... | 著者 | Mills, D.J, Vitt, S, Strauss, M, Shima, S, Vonck, J. | 登録日 | 2012-12-12 | 公開日 | 2013-03-06 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | De Novo Modeling of the F420-Reducing [Nife]-Hydrogenase from a Methanogenic Archaeon by Cryo-Electron Microscopy Elife, 2, 2013
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3QQX
| Reduced Native Intermediate of the Multicopper Oxidase CueO | 分子名称: | Blue copper oxidase CueO, COPPER (I) ION, COPPER (II) ION, ... | 著者 | Montfort, W.R, Roberts, S.A, Singh, S.K. | 登録日 | 2011-02-16 | 公開日 | 2012-02-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | CueO E506D Mutant: Crystal Structure of Reduced Native Intermediate, Kinetics, and Impairment of Product Release To be Published
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5KJ0
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH DB-1-264-2 | 分子名称: | 1,2-ETHANEDIOL, 4-[[(7~{R})-8-cyclopentyl-7-ethyl-5-methyl-6-oxidanylidene-7~{H}-pteridin-2-yl]-methyl-amino]-3-methoxy-~{N}-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4 | 著者 | Zhu, J.-Y, Ember, S.W, Schonbrunn, E. | 登録日 | 2016-06-17 | 公開日 | 2017-08-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET. ChemMedChem, 11, 2016
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6QXD
| Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site. | 分子名称: | (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, COPPER (II) ION, Tyrosinase | 著者 | Deri Zenaty, B, Gitto, R, Pazy, Y, Fishman, A. | 登録日 | 2019-03-07 | 公開日 | 2019-06-19 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.317 Å) | 主引用文献 | Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur.J.Med.Chem., 178, 2019
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6EI4
| Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site | 分子名称: | COPPER (II) ION, Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone | 著者 | Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. | 登録日 | 2017-09-17 | 公開日 | 2018-04-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
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6XBU
| polymerase domain of polymerase-theta | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*TP*CP*AP*TP*TP*G)-3'), DNA polymerase theta, ... | 著者 | Chen, X, Pomerantz, R, Zhao, J. | 登録日 | 2020-06-07 | 公開日 | 2021-06-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair. Sci Adv, 7, 2021
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5OAE
| Crystal Structure of tyrosinase from Bacillus megaterium with SVF inhibitor in the active site | 分子名称: | 1-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanone, COPPER (II) ION, Tyrosinase | 著者 | Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. | 登録日 | 2017-06-21 | 公開日 | 2018-04-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
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3HYF
| Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | 分子名称: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | 著者 | Lansdon, E.B, Kirschberg, T.A. | 登録日 | 2009-06-22 | 公開日 | 2009-10-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52, 2009
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4QL1
| Crystal structure of human WDR5 in complex with compound OICR-9429 | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... | 著者 | Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2014-06-10 | 公開日 | 2014-12-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia. Nat.Chem.Biol., 11, 2015
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