6QXD
Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site.
Summary for 6QXD
Entry DOI | 10.2210/pdb6qxd/pdb |
Descriptor | Tyrosinase, COPPER (II) ION, (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, ... (4 entities in total) |
Functional Keywords | tyrosinase, inhibitor, ligand, oxidoreductase |
Biological source | Bacillus megaterium |
Total number of polymer chains | 2 |
Total formula weight | 67221.07 |
Authors | Deri Zenaty, B.,Gitto, R.,Pazy, Y.,Fishman, A. (deposition date: 2019-03-07, release date: 2019-06-19, Last modification date: 2024-01-24) |
Primary citation | Ielo, L.,Deri, B.,Germano, M.P.,Vittorio, S.,Mirabile, S.,Gitto, R.,Rapisarda, A.,Ronsisvalle, S.,Floris, S.,Pazy, Y.,Fais, A.,Fishman, A.,De Luca, L. Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur.J.Med.Chem., 178:380-389, 2019 Cited by PubMed: 31202126DOI: 10.1016/j.ejmech.2019.06.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.317 Å) |
Structure validation
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