6EI4

Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site

Summary for 6EI4

Entry DOI	10.2210/pdb6ei4/pdb
Descriptor	Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone, COPPER (II) ION, ... (4 entities in total)
Functional Keywords	tyrosinase, inhibitor, ligand, oxidoreductase
Biological source	Bacillus megaterium
Total number of polymer chains	2
Total formula weight	67771.87
Authors	Deri, B.,Gitto, R.,Pazy Benhar, Y.,Fishman, A. (deposition date: 2017-09-17, release date: 2018-04-25, Last modification date: 2024-01-17)
Primary citation	Ferro, S.,Deri, B.,Germano, M.P.,Gitto, R.,Ielo, L.,Buemi, M.R.,Certo, G.,Vittorio, S.,Rapisarda, A.,Pazy, Y.,Fishman, A.,De Luca, L. Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61:3908-3917, 2018 Cited by PubMed: 29634898 DOI: 10.1021/acs.jmedchem.7b01745 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation