5OAE

Crystal Structure of tyrosinase from Bacillus megaterium with SVF inhibitor in the active site

Summary for 5OAE

Entry DOI	10.2210/pdb5oae/pdb
Descriptor	Tyrosinase, COPPER (II) ION, 1-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanone, ... (4 entities in total)
Functional Keywords	tyrosinase inhibitor ligand, oxidoreductase
Biological source	Bacillus megaterium
Total number of polymer chains	2
Total formula weight	67303.31
Authors	Deri, B.,Gitto, R.,Pazy Benhar, Y.,Fishman, A. (deposition date: 2017-06-21, release date: 2018-04-25, Last modification date: 2024-01-17)
Primary citation	Ferro, S.,Deri, B.,Germano, M.P.,Gitto, R.,Ielo, L.,Buemi, M.R.,Certo, G.,Vittorio, S.,Rapisarda, A.,Pazy, Y.,Fishman, A.,De Luca, L. Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61:3908-3917, 2018 Cited by PubMed: 29634898 DOI: 10.1021/acs.jmedchem.7b01745 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation