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6XZW
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BU of 6xzw by Molmil
Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.
分子名称: 1,2-ETHANEDIOL, Fab 4B3 (heavy chain), Fab 4B3 (light chain), ...
著者Veggi, D, Cozzi, R.
登録日2020-02-05
公開日2020-10-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.
Plos Pathog., 16, 2020
7NRU
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BU of 7nru by Molmil
Structure of a natural chimera of meningococcal factor H binding protein belonging to NL096 strain
分子名称: Factor H binding protein variant 1-2,3.x, SULFATE ION
著者Veggi, D, Malito, E, Bottomley, M.J.
登録日2021-03-04
公開日2022-06-08
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.21998358 Å)
主引用文献Structural characterization of a cross-protective natural chimera of factor H binding protein from meningococcal serogroup B strain NL096.
Comput Struct Biotechnol J, 20, 2022
8BK2
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BU of 8bk2 by Molmil
X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ...
著者Veggi, D, Bottomley, J.M.
登録日2022-11-08
公開日2023-11-22
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Bactericidal human monoclonal antibody 1B1 specific for meningococcal factor H binding protein variant 2 and displaces human factor H
To Be Published
6H2Y
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BU of 6h2y by Molmil
human Fab 1E6 bound to fHbp variant 3 from Neisseria meningitidis serogroup B
分子名称: 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, ...
著者Veggi, D, Bianchi, F, Cozzi, R, Malito, E, Bottomley, M.J.
登録日2018-07-17
公開日2019-08-14
最終更新日2020-02-26
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6.
Faseb J., 33, 2019
8C27
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BU of 8c27 by Molmil
Domain 3 of Group B Streptococcus pilus protein as scaffold for the display of foreign epitopes
分子名称: 1,2-ETHANEDIOL, PI-2a backbone protein
著者Veggi, D, Cappelli, L, Cozzi, R.
登録日2022-12-21
公開日2024-01-10
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Computational structure-based approach to study chimeric antigens using a new protein scaffold displaying foreign epitopes.
Faseb J., 38, 2024
7O4W
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BU of 7o4w by Molmil
Crystal structure of diphtheria toxin mutant CRM197 with a disulphide bond replaced by a Cys-Acetone-Cys bridge
分子名称: 1,2-ETHANEDIOL, 1-hydroxypropan-2-one, ACETATE ION, ...
著者Veggi, D, Dello Iacono, L.
登録日2021-04-07
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.03002071 Å)
主引用文献Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.
Chem Sci, 13, 2022
5M63
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BU of 5m63 by Molmil
Crystal structure of group B Streptococcus type III DP2 oligosaccharide bound to Fab NVS-1-19-5
分子名称: (2~{R},3~{R},4~{S},5~{S})-2-[bis(oxidanyl)methyl]-5-(hydroxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, H chain of Fab NVS-1-19-5, ...
著者Carboni, F, Adamo, R, Veggi, D, Rappuoli, R, Malito, E, Margarit, I.R, Berti, F.
登録日2016-10-24
公開日2017-05-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1YS5
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BU of 1ys5 by Molmil
Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis
分子名称: lipoprotein
著者Cantini, F, Savino, S, Masignani, V, Pizza, M, Scarselli, M, Swennen, E, Romagnoli, G, Veggi, D, Banci, L, Rappuoli, R.
登録日2005-02-07
公開日2006-02-07
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis
J.Biol.Chem., 281, 2006
4E9L
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BU of 4e9l by Molmil
FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections
分子名称: Attaching and effacing protein, pathogenesis factor
著者Spraggon, G, Nesta, B, Alteri, C, Gomes Moriel, D, Rosini, R, Veggi, D, Smith, S, Bertoldi, I, Pastorello, I, Ferlenghi, I, Fontana, M.R, Frankel, G, Mobley, H.L.T, Rappuoli, R, Pizza, M, Serino, L, Soriana, M.
登録日2012-03-21
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.
MBio, 3, 2012
3KVD
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BU of 3kvd by Molmil
Crystal structure of the Neisseria meningitidis Factor H binding protein, fHbp (GNA1870) at 2.0 A resolution
分子名称: Lipoprotein
著者Cendron, L, Veggi, D, Girardi, E, Zanotti, G.
登録日2009-11-30
公開日2010-12-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the uncomplexed Neisseria meningitidis factor H-binding protein fHbp (rLP2086).
Acta Crystallogr.,Sect.F, 67, 2011
2YPV
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BU of 2ypv by Molmil
Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody
分子名称: 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN
著者Malito, E, Veggi, D, Bottomley, M.J.
登録日2012-11-01
公開日2013-02-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
2LFU
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BU of 2lfu by Molmil
The structure of a N. meningitides protein targeted for vaccine development
分子名称: Gna2132
著者Esposito, V, Musi, V, De Chiara, C, Kelly, G, Veggi, D, Pizza, M, Pastore, A.
登録日2011-07-15
公開日2011-10-19
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure of the C-terminal Domain of Neisseria Heparin Binding Antigen (NHBA), One of the Main Antigens of a Novel Vaccine against Neisseria meningitidis.
J.Biol.Chem., 286, 2011
2KXI
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BU of 2kxi by Molmil
Solution NMR structure of the apoform of NarE (NMB1343)
分子名称: Uncharacterized protein
著者Koehler, C, Carlier, L, Veggi, D, Soriani, M, Pizza, M, Boelens, R, Bonvin, A.M.J.J.
登録日2010-05-06
公開日2011-03-02
最終更新日2018-08-08
実験手法SOLUTION NMR
主引用文献Solution NMR structure of the apoform of NarE (NMB1343)
To be Published
2L4O
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BU of 2l4o by Molmil
Solution structure of the Streptococcus pneumoniae RrgB pilus backbone D1 domain
分子名称: Cell wall surface anchor family protein
著者Gentile, M.A, Melchiorre, S, Emolo, C, Moschioni, M, Gianfaldoni, C, Pancotto, L, Ferlenghi, I, Scarselli, M, Pansegrau, W, Veggi, D, Merola, M, Cantini, F, Ruggiero, P, Banci, L, Masignani, V.
登録日2010-10-11
公開日2011-03-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the Streptococcus pneumoniae RrgB pilus backbone D1 domain: in vivo protection and implications for the molecular mechanisms of pilus polymerization
To be Published
2KC0
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BU of 2kc0 by Molmil
Solution structure of the factor H binding protein
分子名称: lipoprotein
著者Cantini, F, Veggi, D, Dragonetti, S, Savino, S, Scarselli, M, Romagnoli, G, Pizza, M, Banci, L, Rappuoli, R.
登録日2008-12-13
公開日2009-02-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution Structure of the Factor H-binding Protein, a Survival Factor and Protective Antigen of Neisseria meningitidis
J.Biol.Chem., 284, 2009
6CUJ
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BU of 6cuj by Molmil
Crystal structure of the C-terminal domain of neisserial heparin binding antigen (NHBA)
分子名称: Gna2132
著者Malito, E, Spraggon, G.
登録日2018-03-26
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.805 Å)
主引用文献Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.
PLoS ONE, 13, 2018
4CJD
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BU of 4cjd by Molmil
Crystal structure of Neisseria meningitidis trimeric autotransporter and vaccine antigen NadA
分子名称: IODIDE ION, NADA
著者Malito, E, Biancucci, M, Spraggon, G, Bottomley, M.J.
登録日2013-12-19
公開日2014-11-26
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.056 Å)
主引用文献Structure of the Meningococcal Vaccine Antigen Nada and Epitope Mapping of a Bactericidal Antibody.
Proc.Natl.Acad.Sci.USA, 111, 2014
5T5F
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BU of 5t5f by Molmil
Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
分子名称: Factor H binding protein variant B24, Monoclonal antibody Jar5 heavy chain, Monoclonal antibody Jar5 light chain
著者Malito, E.
登録日2016-08-30
公開日2016-11-09
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy.
Biochem. J., 473, 2016
2Y7S
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BU of 2y7s by Molmil
Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity
分子名称: FACTOR H BINDING PROTEIN
著者Malito, E, Spraggon, G, Bottomley, M.J.
登録日2011-02-01
公開日2011-07-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity.
Sci.Transl.Med, 3, 2011
5N4J
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BU of 5n4j by Molmil
human Fab fragment 10C3 against NHBA from Neisseria meningitidis
分子名称: HEAVY CHAIN, LIGHT CHAIN
著者Maritan, M, Malito, E.
登録日2017-02-10
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.503 Å)
主引用文献Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5NYX
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BU of 5nyx by Molmil
human Fab fragment 5H2 against NHBA from Neisseria meningitidis
分子名称: GLYCEROL, HEAVY CHAIN, LIGHT CHAIN, ...
著者Malito, E, Maritan, M.
登録日2017-05-12
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.
PLoS ONE, 13, 2018
5N4G
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BU of 5n4g by Molmil
human Fab fragment 12E1 against NHBA from Neisseria meningitidis
分子名称: 1,2-ETHANEDIOL, HEAVY CHAIN, LIGHT CHAIN, ...
著者Maritan, M, Malito, E.
登録日2017-02-10
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5O1R
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BU of 5o1r by Molmil
human Fab 5H2 bound to NHBA-C3 from Neisseria meningitidis serogroup B
分子名称: 1,2-ETHANEDIOL, GNA2132, IGH@ protein, ...
著者Malito, E, Maritan, M.
登録日2017-05-19
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.
PLoS ONE, 13, 2018

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