1AVA
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![BU of 1ava by Molmil](/molmil-images/mine/1ava) | AMY2/BASI PROTEIN-PROTEIN COMPLEX FROM BARLEY SEED | 分子名称: | BARLEY ALPHA-AMYLASE 2(CV MENUET), BARLEY ALPHA-AMYLASE/SUBTILISIN INHIBITOR, CALCIUM ION | 著者 | Vallee, F, Kadziola, A, Bourne, Y, Juy, M, Svensson, B, Haser, R. | 登録日 | 1997-09-15 | 公開日 | 1999-03-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Barley alpha-amylase bound to its endogenous protein inhibitor BASI: crystal structure of the complex at 1.9 A resolution. Structure, 6, 1998
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5T21
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![BU of 5t21 by Molmil](/molmil-images/mine/5t21) | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019. | 分子名称: | 2-[(4-oxidanylcyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydroindol-1-yl)benzamide, Heat shock protein HSP 90-alpha | 著者 | Vallee, F, Dupuy, A. | 登録日 | 2016-08-23 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019. To Be Published
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4CP6
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![BU of 4cp6 by Molmil](/molmil-images/mine/4cp6) | The Crystal structure of Pneumococcal vaccine antigen PcpA | 分子名称: | CHOLINE BINDING PROTEIN PCPA | 著者 | Vallee, F, Steier, V, Oloo, E, Chawla, D, Vonrhein, C, Steinmetz, A, Mathieu, M, Rak, A, Mikol, V, Oomen, R. | 登録日 | 2014-01-31 | 公開日 | 2015-02-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | The Crystal Structure of Pneumoccocal Vaccine Antigen Pcpa To be Published
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1DL2
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![BU of 1dl2 by Molmil](/molmil-images/mine/1dl2) | CRYSTAL STRUCTURE OF CLASS I ALPHA-1,2-MANNOSIDASE FROM SACCHAROMYCES CEREVISIAE AT 1.54 ANGSTROM RESOLUTION | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CLASS I ALPHA-1,2-MANNOSIDASE, ... | 著者 | Vallee, F, Lipari, F, Yip, P, Herscovics, A, Howell, P.L. | 登録日 | 1999-12-08 | 公開日 | 2000-02-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Crystal structure of a class I alpha1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control. EMBO J., 19, 2000
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1DCN
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![BU of 1dcn by Molmil](/molmil-images/mine/1dcn) | INACTIVE MUTANT H162N OF DELTA 2 CRYSTALLIN WITH BOUND ARGININOSUCCINATE | 分子名称: | ARGININOSUCCINATE, DELTA 2 CRYSTALLIN | 著者 | Vallee, F, Turner, M.A, Lindley, P, Howell, P.L. | 登録日 | 1998-10-29 | 公開日 | 1999-04-27 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of an inactive duck delta II crystallin mutant with bound argininosuccinate. Biochemistry, 38, 1999
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1FMI
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![BU of 1fmi by Molmil](/molmil-images/mine/1fmi) | CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE | 分子名称: | CALCIUM ION, ENDOPLASMIC RETICULUM ALPHA-MANNOSIDASE I, SULFATE ION | 著者 | Vallee, F, Karaveg, K, Herscovics, A, Moremen, K.W, Howell, P.L. | 登録日 | 2000-08-17 | 公開日 | 2001-01-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases. J.Biol.Chem., 275, 2000
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1FO3
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![BU of 1fo3 by Molmil](/molmil-images/mine/1fo3) | CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE | 分子名称: | ALPHA1,2-MANNOSIDASE, CALCIUM ION, KIFUNENSINE, ... | 著者 | Vallee, F, Karaveg, K, Moremen, K.W, Herscovics, A, Howell, P.L. | 登録日 | 2000-08-24 | 公開日 | 2001-01-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases. J.Biol.Chem., 275, 2000
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1FO2
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![BU of 1fo2 by Molmil](/molmil-images/mine/1fo2) | CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN | 分子名称: | 1-DEOXYMANNOJIRIMYCIN, ALPHA1,2-MANNOSIDASE, CALCIUM ION, ... | 著者 | Vallee, F, Karaveg, K, Moremen, K.W, Herscovics, A, Howell, P.L. | 登録日 | 2000-08-24 | 公開日 | 2001-01-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases. J.Biol.Chem., 275, 2000
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5LRZ
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![BU of 5lrz by Molmil](/molmil-images/mine/5lrz) | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003643501 | 分子名称: | 6-bromanyl-~{N}-[(9~{R})-4-quinolin-3-yl-9~{H}-fluoren-9-yl]-3~{H}-imidazo[4,5-b]pyridine-7-carboxamide, Heat shock protein HSP 90-alpha | 著者 | Vallee, F, Dupuy, A. | 登録日 | 2016-08-22 | 公開日 | 2017-09-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH A003643501 To Be Published
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5LR1
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![BU of 5lr1 by Molmil](/molmil-images/mine/5lr1) | |
5LQ9
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![BU of 5lq9 by Molmil](/molmil-images/mine/5lq9) | |
5LS1
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![BU of 5ls1 by Molmil](/molmil-images/mine/5ls1) | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475 | 分子名称: | 2-[(4-oxidanylidenecyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxidanylidene-5,7-dihydroindol-1-yl)benzamide, Heat shock protein HSP 90-alpha | 著者 | Vallee, F, Dupuy, A. | 登録日 | 2016-08-22 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR166475 To Be Published
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5LR7
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![BU of 5lr7 by Molmil](/molmil-images/mine/5lr7) | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR567530 | 分子名称: | Heat shock protein HSP 90-alpha, ~{N}-[(9~{R})-4-(5-fluoranyl-1~{H}-benzimidazol-2-yl)-9~{H}-fluoren-9-yl]-1~{H}-pyrrolo[2,3-b]pyridine-4-carboxamide | 著者 | Vallee, F, Dupuy, A. | 登録日 | 2016-08-18 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR567530 To Be Published
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5HCG
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![BU of 5hcg by Molmil](/molmil-images/mine/5hcg) | CRYSTAL STRUCTURE OF FREE-CODV. | 分子名称: | CODV heavy-chain, CODV light chain | 著者 | Vallee, F, Dupuy, A, Rak, A. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications. Mabs, 8, 2016
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6SBO
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![BU of 6sbo by Molmil](/molmil-images/mine/6sbo) | Estrogen receptor mutant L536S | 分子名称: | 6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor | 著者 | Vallee, F, Steier, V, Rak, A. | 登録日 | 2019-07-22 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J.Med.Chem., 63, 2020
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5BX0
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![BU of 5bx0 by Molmil](/molmil-images/mine/5bx0) | |
5FHX
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![BU of 5fhx by Molmil](/molmil-images/mine/5fhx) | CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION. | 分子名称: | Antibody fragment light chain, Interleukin-4, PHOSPHATE ION, ... | 著者 | Vallee, F, Dupuy, A, Rak, A. | 登録日 | 2015-12-22 | 公開日 | 2016-03-30 | 最終更新日 | 2018-10-24 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications. Mabs, 8, 2016
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5HNI
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![BU of 5hni by Molmil](/molmil-images/mine/5hni) | CRYSTAL STRUCTURE OF CMET WT with compound 3 | 分子名称: | Hepatocyte growth factor receptor, methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1H-benzimidazol-2-yl)carbamate | 著者 | Vallee, F, Houtmann, J. | 登録日 | 2016-01-18 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
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5HO6
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![BU of 5ho6 by Molmil](/molmil-images/mine/5ho6) | CRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD. | 分子名称: | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor | 著者 | Vallee, F, Houtmann, J. | 登録日 | 2016-01-19 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
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5HOR
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![BU of 5hor by Molmil](/molmil-images/mine/5hor) | Crystal structure of c-Met-M1250T in complex with SAR125844. | 分子名称: | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor | 著者 | Vallee, F, Houtmann, J, Marquette, J.-P. | 登録日 | 2016-01-19 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
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5HLW
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![BU of 5hlw by Molmil](/molmil-images/mine/5hlw) | Crystal structure of c-Met mutant Y1230H in complex with compound 14 | 分子名称: | 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea, CHLORIDE ION, Hepatocyte growth factor receptor | 著者 | Vallee, F, Pouzieux, S, Marquette, J.P, Houtmann, J. | 登録日 | 2016-01-15 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
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5HOA
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![BU of 5hoa by Molmil](/molmil-images/mine/5hoa) | Crystal structure of c-Met L1195V in complex with SAR125844 | 分子名称: | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea, Hepatocyte growth factor receptor | 著者 | Vallee, F, Marquette, J.-P. | 登録日 | 2016-01-19 | 公開日 | 2016-11-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59, 2016
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2YK9
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![BU of 2yk9 by Molmil](/molmil-images/mine/2yk9) | Tricyclic series of Hsp90 inhibitors | 分子名称: | 4-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)FLUOREN-9-ONE, HEAT SHOCK PROTEIN HSP 90-ALPHA | 著者 | Dupuy, A, Vallee, F. | 登録日 | 2011-05-26 | 公開日 | 2011-10-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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2YKB
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![BU of 2ykb by Molmil](/molmil-images/mine/2ykb) | Tricyclic series of Hsp90 inhibitors | 分子名称: | HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL]-SUCCINAMIDE | 著者 | Dupuy, A, Vallee, F. | 登録日 | 2011-05-26 | 公開日 | 2011-10-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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2YKC
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![BU of 2ykc by Molmil](/molmil-images/mine/2ykc) | Tricyclic series of Hsp90 inhibitors | 分子名称: | HEAT SHOCK PROTEIN HSP 90-ALPHA, N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL-ISONICOTINAMIDE | 著者 | Dupuy, A, Vallee, F. | 登録日 | 2011-05-26 | 公開日 | 2011-10-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J.Med.Chem., 54, 2011
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