5HLW

Crystal structure of c-Met mutant Y1230H in complex with compound 14

Summary for 5HLW

Entry DOI	10.2210/pdb5hlw/pdb
Descriptor	Hepatocyte growth factor receptor, CHLORIDE ION, 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea, ... (4 entities in total)
Functional Keywords	transferase, transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	34476.48
Authors	Vallee, F.,Pouzieux, S.,Marquette, J.P.,Houtmann, J. (deposition date: 2016-01-15, release date: 2016-11-23)
Primary citation	Ugolini, A.,Kenigsberg, M.,Rak, A.,Vallee, F.,Houtmann, J.,Lowinski, M.,Capdevila, C.,Khider, J.,Albert, E.,Martinet, N.,Nemecek, C.,Grapinet, S.,Bacque, E.,Roesner, M.,Delaisi, C.,Calvet, L.,Bonche, F.,Semiond, D.,Egile, C.,Goulaouic, H.,Schio, L. Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844). J.Med.Chem., 59:7066-7074, 2016 Cited by PubMed: 27355974 DOI: 10.1021/acs.jmedchem.6b00280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation